STRINGSTRING
SMAD1 SMAD1 LOC100010741 LOC100010741 BIRC2 BIRC2 NKD2 NKD2 WNT2B WNT2B MYC MYC GDF5 GDF5 PATJ PATJ DVL3 DVL3 CDH1 CDH1 BMP2 BMP2 FZD4 FZD4 AXIN2 AXIN2 TGFB2 TGFB2 DLG2 DLG2 AMH AMH APC2 APC2 WNT11 WNT11 FZD6 FZD6 TGFB3 TGFB3 PARD6A PARD6A FRMD1 FRMD1 YWHAZ YWHAZ DVL1 DVL1 DLG4 DLG4 FBXW11 FBXW11 DVL2 DVL2 F7G4H7_MONDO F7G4H7_MONDO FZD8 FZD8 WNT7B WNT7B WWC1 WWC1 LLGL2 LLGL2 LATS2 LATS2 TGFB1 TGFB1 WNT7A WNT7A FZD3 FZD3 SMAD2 SMAD2 YWHAH YWHAH MPP5 MPP5 BMP6 BMP6 PPP2R2B PPP2R2B SNAI2 SNAI2 MOB1A MOB1A FZD1 FZD1 CTNNB1 CTNNB1 LIMD1 LIMD1 FZD2 FZD2 WTIP WTIP LOC100028958 LOC100028958 CTNNA1 CTNNA1 TGFBR1 TGFBR1 CRB1 CRB1 BMP4 BMP4 SAV1 SAV1 FRMD6 FRMD6 APC APC YWHAG YWHAG FZD9 FZD9 WNT3A WNT3A PPP2CA PPP2CA PPP2R1B PPP2R1B ID2 ID2 YWHAQ YWHAQ TGFBR2 TGFBR2 WNT6 WNT6 WNT16 WNT16 PPP1CB PPP1CB TCF7L1 TCF7L1 WNT2 WNT2 FZD5 FZD5 PRKCI PRKCI YWHAB YWHAB BMPR2 BMPR2 FZD7 FZD7 PARD6B PARD6B BMP7 BMP7 PPP2R2A PPP2R2A LATS1 LATS1 CTNNA3 CTNNA3 CCN2 CCN2 LOC100031977 LOC100031977 CCND2 CCND2 WNT5A WNT5A CSNK1E CSNK1E BMP5 BMP5 PPP2CB PPP2CB RASSF6 RASSF6 AREG AREG BMPR1B BMPR1B ID1 ID1 PPP2R2D PPP2R2D CRB2 CRB2 LEF1 LEF1 PPP2R1A PPP2R1A WWTR1 WWTR1 LOC100617582 LOC100617582 LOC100016601 LOC100016601 TEAD3 TEAD3 TCF7 TCF7 TEAD1 TEAD1 WNT10A WNT10A GLI2 GLI2 LOC100020439 LOC100020439 F6TU13_MONDO F6TU13_MONDO LLGL1 LLGL1 AFP AFP K7E1M2_MONDO K7E1M2_MONDO BBC3 BBC3 BIRC5 BIRC5 AJUBA AJUBA WNT9B WNT9B AXIN1 AXIN1 STK3 STK3 PRKCZ PRKCZ WNT3 WNT3 ITGB2 ITGB2 YAP1 YAP1 NKD1 NKD1 ACTG1 ACTG1 PPP1CC PPP1CC SERPINE1 SERPINE1 SMAD3 SMAD3 GDF7 GDF7 CCND1 CCND1 FGF1 FGF1 TP53BP2 TP53BP2 BTRC BTRC CCND3 CCND3 PARD3 PARD3 DLG1 DLG1 WNT1 WNT1 TCF7L2 TCF7L2 WNT9A WNT9A NF2 NF2 WNT5B WNT5B SMAD7 SMAD7 CSNK1D CSNK1D PARD6G PARD6G RASSF1 RASSF1 CTNNA2 CTNNA2 WNT4 WNT4 WNT8B WNT8B GDF6 GDF6 TEAD4 TEAD4 FZD10 FZD10 GSK3B GSK3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD1Mothers against decapentaplegic homolog. (465 aa)
LOC100010741CARD domain-containing protein. (585 aa)
BIRC2Uncharacterized protein. (383 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (451 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
GDF5Growth differentiation factor 5. (495 aa)
PATJUncharacterized protein. (680 aa)
DVL3Dishevelled segment polarity protein 3. (635 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (888 aa)
BMP2Bone morphogenetic protein 2. (436 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
AXIN2Axin 2. (838 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
DLG2Uncharacterized protein. (392 aa)
AMHTGF_BETA_2 domain-containing protein. (607 aa)
APC2APC_N_CC domain-containing protein. (1586 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PARD6APar-6 family cell polarity regulator alpha. (518 aa)
FRMD1FERM domain-containing protein. (557 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
DVL1Dishevelled segment polarity protein 1. (705 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (724 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
F7G4H7_MONDOFERM domain-containing protein. (482 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (710 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WWC1WW and C2 domain containing 1. (1115 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1046 aa)
LATS2Large tumor suppressor kinase 2. (1123 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (200 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (248 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
BMP6Bone morphogenetic protein 6. (534 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (484 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
MOB1AUncharacterized protein. (216 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
CTNNB1Catenin beta 1. (781 aa)
LIMD1LIM domains containing 1. (714 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
WTIPWT1 interacting protein. (465 aa)
LOC100028958Uncharacterized protein. (375 aa)
CTNNA1Uncharacterized protein. (906 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
BMP4Bone morphogenetic protein 4. (410 aa)
SAV1Salvador family WW domain containing protein 1. (397 aa)
FRMD6FERM domain containing 6. (465 aa)
APCAPC regulator of WNT signaling pathway. (2936 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (627 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
TCF7L1Transcription factor 7 like 1. (613 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (579 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (249 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
PARD6BUncharacterized protein. (370 aa)
BMP7Bone morphogenetic protein 7. (432 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (419 aa)
LATS1Large tumor suppressor kinase 1. (1151 aa)
CTNNA3Uncharacterized protein. (454 aa)
CCN2Cellular communication network factor 2. (351 aa)
LOC100031977TGF_BETA_2 domain-containing protein. (436 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (290 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
CSNK1EUncharacterized protein. (210 aa)
BMP5Bone morphogenetic protein 5. (455 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
RASSF6Ras association domain family member 6. (464 aa)
AREGAmphiregulin. (237 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (534 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (150 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (417 aa)
CRB2Uncharacterized protein. (1430 aa)
LEF1Lymphoid enhancer binding factor 1. (401 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (410 aa)
WWTR1WW domain containing transcription regulator 1. (413 aa)
LOC100617582Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1107 aa)
LOC100016601Uncharacterized protein. (374 aa)
TEAD3TEA domain transcription factor 3. (408 aa)
TCF7Transcription factor 7. (442 aa)
TEAD1TEA domain transcription factor 1. (433 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
GLI2GLI family zinc finger 2. (1569 aa)
LOC100020439Uncharacterized protein; Belongs to the actin family. (374 aa)
F6TU13_MONDOProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1053 aa)
AFPAlpha fetoprotein. (605 aa)
K7E1M2_MONDOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1138 aa)
BBC3Uncharacterized protein. (318 aa)
BIRC5Uncharacterized protein. (127 aa)
AJUBAAjuba LIM protein. (537 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (427 aa)
AXIN1Axin 1. (875 aa)
STK3Serine/threonine kinase 3. (555 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (589 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ITGB2Integrin beta. (792 aa)
YAP1Yes associated protein 1. (512 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (467 aa)
ACTG1Uncharacterized protein. (375 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (413 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
GDF7TGF_BETA_2 domain-containing protein. (461 aa)
CCND1Uncharacterized protein. (67 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
TP53BP2Tumor protein p53 binding protein 2. (1166 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (300 aa)
PARD3Par-3 family cell polarity regulator. (1358 aa)
DLG1Uncharacterized protein; Belongs to the MAGUK family. (855 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
TCF7L2Transcription factor 7 like 2. (579 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
NF2Neurofibromin 2. (595 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (447 aa)
SMAD7Mothers against decapentaplegic homolog. (459 aa)
CSNK1DCasein kinase 1 delta. (501 aa)
PARD6GPar-6 family cell polarity regulator gamma. (383 aa)
RASSF1Ras association domain family member 1. (367 aa)
CTNNA2Uncharacterized protein. (651 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
GDF6Growth differentiation factor 6. (505 aa)
TEAD4TEA domain transcription factor 4. (478 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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