STRINGSTRING
SRC SRC PAK6 PAK6 LOC100010741 LOC100010741 BIRC2 BIRC2 RAC2 RAC2 PDGFD PDGFD RAP1A RAP1A ITGB8 ITGB8 MYLPF MYLPF PDGFC PDGFC COL2A1 COL2A1 PIK3R3 PIK3R3 LAMB3 LAMB3 IGF1 IGF1 SHC4 SHC4 PIP5K1B PIP5K1B RAC3 RAC3 JUN JUN COMP COMP VEGFC VEGFC PRKCA PRKCA COL4A2 COL4A2 PAK5 PAK5 PAK1 PAK1 ITGB6 ITGB6 TNR TNR THBS2 THBS2 MYL5 MYL5 RAF1 RAF1 AKT3 AKT3 F6PU44_MONDO F6PU44_MONDO LAMC1 LAMC1 LAMC2 LAMC2 RAP1B RAP1B GRB2 GRB2 TLN1 TLN1 COL6A3 COL6A3 AKT2 AKT2 SOS1 SOS1 ITGA6 ITGA6 EGFR EGFR FLT1 FLT1 ITGA11 ITGA11 PDGFB PDGFB MAP2K1 MAP2K1 PDGFRB PDGFRB ITGA8 ITGA8 ITGA4 ITGA4 ITGAV ITGAV ITGB3 ITGB3 CTNNB1 CTNNB1 TLN2 TLN2 MYL2 MYL2 ITGA2B ITGA2B SOS2 SOS2 COL1A1 COL1A1 LOC100028958 LOC100028958 MYLK3 MYLK3 COL6A6 COL6A6 ITGA9 ITGA9 SHC3 SHC3 AKT1 AKT1 TNXB TNXB XIAP XIAP FLNC FLNC PPP1CB PPP1CB MAPK3 MAPK3 MET MET CAV1 CAV1 MYL7 MYL7 LAMB1 LAMB1 COL9A3 COL9A3 HGF HGF SHC1 SHC1 VEGFD VEGFD COL9A2 COL9A2 CRKL CRKL MAPK1 MAPK1 LAMA4 LAMA4 CCND2 CCND2 MYLK MYLK ITGB5 ITGB5 PAK2 PAK2 COL9A1 COL9A1 PIP5K1A PIP5K1A VEGFA VEGFA VTN VTN RASGRF1 RASGRF1 ITGA1 ITGA1 ITGA2 ITGA2 PIK3R1 PIK3R1 THBS4 THBS4 PPP1R12A PPP1R12A PDGFRA PDGFRA KDR KDR MAPK10 MAPK10 LOC100017469 LOC100017469 CHAD CHAD COL4A3 COL4A3 PIK3CA PIK3CA LOC100016601 LOC100016601 MAPK9 MAPK9 CDC42 CDC42 VAV1 VAV1 F7CI75_MONDO F7CI75_MONDO BRAF BRAF LAMA3 LAMA3 LOC100020439 LOC100020439 COL4A1 COL4A1 EGF EGF COL6A5 COL6A5 LAMA2 LAMA2 ITGB1 ITGB1 LAMB2 LAMB2 ITGB4 ITGB4 LAMA1 LAMA1 ZYX ZYX ARHGAP5 ARHGAP5 MYL9 MYL9 THBS1 THBS1 BAD BAD FLNA FLNA CAV2 CAV2 ACTG1 ACTG1 PRKCB PRKCB PDGFA PDGFA PPP1CC PPP1CC FLT4 FLT4 MYLK4 MYLK4 MYL10 MYL10 FN1 FN1 ILK ILK VCL VCL PGF PGF IBSP IBSP CCND1 CCND1 PARVG PARVG ARHGAP35 ARHGAP35 CAV3 CAV3 ERBB2 ERBB2 CCND3 CCND3 SPP1 SPP1 PTK2 PTK2 ACTN4 ACTN4 CAPN2 CAPN2 PARVA PARVA PIK3CB PIK3CB VAV3 VAV3 RELN RELN ROCK1 ROCK1 MYL12A MYL12A PAK4 PAK4 RHOA RHOA IGF1R IGF1R GSK3B GSK3B HRAS HRAS PARVB PARVB VEGFB VEGFB ROCK2 ROCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (550 aa)
PAK6P21 (RAC1) activated kinase 6. (592 aa)
LOC100010741CARD domain-containing protein. (585 aa)
BIRC2Uncharacterized protein. (383 aa)
RAC2Rac family small GTPase 2. (281 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
RAP1AUncharacterized protein. (177 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (765 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (180 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
COL2A1Collagen type II alpha 1 chain. (886 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
LAMB3Laminin subunit beta 3. (1171 aa)
IGF1Insulin like growth factor 1. (225 aa)
SHC4SHC adaptor protein 4. (678 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (556 aa)
RAC3Rac family small GTPase 3. (192 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
COMPCartilage oligomeric matrix protein. (728 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (351 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
COL4A2Collagen type IV alpha 2 chain. (1455 aa)
PAK5Non-specific serine/threonine protein kinase. (812 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TNRTenascin R. (1358 aa)
THBS2Thrombospondin 2. (1175 aa)
MYL5Myosin light chain 5. (170 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
F6PU44_MONDODHR-2 domain-containing protein; Belongs to the DOCK family. (930 aa)
LAMC1Laminin subunit gamma 1. (1486 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
TLN1Talin 1. (2542 aa)
COL6A3Uncharacterized protein. (1849 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1075 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet derived growth factor receptor beta. (1061 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1058 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
CTNNB1Catenin beta 1. (781 aa)
TLN2Talin 2. (2542 aa)
MYL2Myosin light chain 2. (166 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1044 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
COL1A1Collagen type I alpha 1 chain. (1430 aa)
LOC100028958Uncharacterized protein. (375 aa)
MYLK3Myosin light chain kinase 3. (846 aa)
COL6A6Uncharacterized protein. (1187 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1017 aa)
SHC3SHC adaptor protein 3. (602 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TNXBTenascin XB. (536 aa)
XIAPX-linked inhibitor of apoptosis. (498 aa)
FLNCFilamin C. (2653 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1387 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
MYL7Myosin light chain 7. (175 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
COL9A3Uncharacterized protein. (496 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
SHC1SHC adaptor protein 1. (577 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
COL9A2Collagen type IX alpha 2 chain. (688 aa)
CRKLUncharacterized protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
LAMA4Laminin subunit alpha 4. (1677 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (290 aa)
MYLKMyosin light chain kinase. (1948 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
PAK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
PIP5K1APIPK domain-containing protein. (630 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
VTNSMB domain-containing protein. (466 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1256 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1178 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
THBS4Thrombospondin 4. (955 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (878 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC100017469Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1570 aa)
CHADChondroadherin. (361 aa)
COL4A3Collagen type IV alpha 3 chain. (1607 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100016601Uncharacterized protein. (374 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CDC42Cell division cycle 42. (191 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
F7CI75_MONDOUncharacterized protein. (223 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
LAMA3Laminin subunit alpha 3. (3340 aa)
LOC100020439Uncharacterized protein; Belongs to the actin family. (374 aa)
COL4A1Collagen type IV alpha 1 chain. (1586 aa)
EGFEpidermal growth factor. (1143 aa)
COL6A5Uncharacterized protein. (1180 aa)
LAMA2Laminin subunit alpha 2. (3063 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (802 aa)
LAMB2Laminin subunit beta 2. (1807 aa)
ITGB4Integrin beta. (1864 aa)
LAMA1Laminin subunit alpha 1. (2951 aa)
ZYXZyxin. (555 aa)
ARHGAP5Rho GTPase activating protein 5. (1505 aa)
MYL9Uncharacterized protein. (172 aa)
THBS1Thrombospondin 1. (1197 aa)
BADUncharacterized protein. (212 aa)
FLNAFilamin A. (2558 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ACTG1Uncharacterized protein. (375 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
MYLK4Protein kinase domain-containing protein. (690 aa)
MYL10Uncharacterized protein. (159 aa)
FN1Fibronectin 1. (2482 aa)
ILKIntegrin linked kinase. (486 aa)
VCLVinculin. (1147 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (207 aa)
IBSPUncharacterized protein. (272 aa)
CCND1Uncharacterized protein. (67 aa)
PARVGParvin gamma. (331 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (242 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (300 aa)
SPP1Uncharacterized protein. (302 aa)
PTK2Uncharacterized protein. (161 aa)
ACTN4Actinin alpha 4. (934 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (707 aa)
PARVAParvin alpha. (380 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
RELNReelin. (3458 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1322 aa)
MYL12AMyosin light chain 12A. (178 aa)
PAK4Non-specific serine/threonine protein kinase. (616 aa)
RHOAUncharacterized protein. (193 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
PARVBParvin beta. (381 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (568 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1482 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: low (14%) [HD]