(51 nodes) RIG-I-like receptor signaling pathway network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (726 aa)
	IFN3	Uncharacterized protein. (184 aa)
	LOC100021419	Type I interferon 5. (184 aa)
	IFNK	Type I interferon 9. (202 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	TRADD	TNFRSF1A associated via death domain. (361 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (706 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (543 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	RNF125	Ring finger protein 125. (232 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
	STING1	Transmembrane protein 173. (381 aa)
	NLRX1	NLR family member X1. (975 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	NFKBIB	NFKB inhibitor beta. (314 aa)
	IRF3	IRF tryptophan pentad repeat domain-containing protein. (409 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	DHX58	DExH-box helicase 58. (689 aa)
	TRIM25	Tripartite motif containing 25. (672 aa)
	AZI2	5-azacytidine induced 2. (389 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (472 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (633 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1491 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
	TKFC	Triokinase and FMN cyclase. (765 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (995 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	DDX3X	Uncharacterized protein; Belongs to the DEAD box helicase family. (629 aa)
	ISG15	Uncharacterized protein. (155 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	LOC100016987	Uncharacterized protein; Belongs to the peptidase C14A family. (472 aa)
	LOC100021467	Uncharacterized protein. (183 aa)
	LOC100021258	Type I interferon 1. (198 aa)
	CASP18	Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1021 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	IFN7	Type I interferon 7. (183 aa)
	MAPK12	Mitogen-activated protein kinase. (364 aa)
	TBKBP1	Uncharacterized protein. (208 aa)
	MAVS	CARD_2 domain-containing protein. (478 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (400 aa)
	IFN4	Type I interferon 4. (183 aa)
	LOC100021368	Uncharacterized protein. (183 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (277 aa)
	IFN2	Type I interferon 2. (183 aa)
	FADD	Uncharacterized protein. (193 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG5	CASP18	ENSMODP00000058749	ENSMODP00000040167	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.507
ATG5	CASP8	ENSMODP00000058749	ENSMODP00000018969	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 8; Belongs to the peptidase C14A family.	0.507
ATG5	DHX58	ENSMODP00000058749	ENSMODP00000018488	Autophagy protein 5; Involved in autophagic vesicle formation.	DExH-box helicase 58.	0.415
ATG5	FADD	ENSMODP00000058749	ENSMODP00000059564	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.792
ATG5	IFIH1	ENSMODP00000058749	ENSMODP00000044985	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon induced with helicase C domain 1.	0.703
ATG5	LOC100016987	ENSMODP00000058749	ENSMODP00000036251	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.507
ATG5	MAVS	ENSMODP00000058749	ENSMODP00000054135	Autophagy protein 5; Involved in autophagic vesicle formation.	CARD_2 domain-containing protein.	0.976
ATG5	NLRX1	ENSMODP00000058749	ENSMODP00000016571	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.581
ATG5	RIPK1	ENSMODP00000058749	ENSMODP00000010574	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.538
AZI2	CHUK	ENSMODP00000018846	ENSMODP00000013213	5-azacytidine induced 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.616
AZI2	IKBKB	ENSMODP00000018846	ENSMODP00000012792	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.616
AZI2	IKBKE	ENSMODP00000018846	ENSMODP00000002458	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.940
AZI2	IKBKG	ENSMODP00000018846	ENSMODP00000011449	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.915
AZI2	TBKBP1	ENSMODP00000018846	ENSMODP00000054111	5-azacytidine induced 2.	Uncharacterized protein.	0.800
CASP18	ATG5	ENSMODP00000040167	ENSMODP00000058749	Uncharacterized protein; Belongs to the peptidase C14A family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.507
CASP18	CASP8	ENSMODP00000040167	ENSMODP00000018969	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.910
CASP18	CYLD	ENSMODP00000040167	ENSMODP00000046674	Uncharacterized protein; Belongs to the peptidase C14A family.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.941
CASP18	FADD	ENSMODP00000040167	ENSMODP00000059564	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.995
CASP18	LOC100016987	ENSMODP00000040167	ENSMODP00000036251	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.913
CASP18	MAP3K7	ENSMODP00000040167	ENSMODP00000047628	Uncharacterized protein; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.435