52 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLR3A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1390 aa)
	IL6	Uncharacterized protein. (220 aa)
	POLR3B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (726 aa)
	IFN3	Uncharacterized protein. (184 aa)
	LOC100021419	Type I interferon 5. (184 aa)
	POLR2E	RNA polymerase II subunit E. (221 aa)
	POLR3F	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (706 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
	POLR3D	RNA polymerase III subunit D. (397 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (543 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	STING1	Transmembrane protein 173. (381 aa)
	NFKBIB	NFKB inhibitor beta. (314 aa)
	IRF3	IRF tryptophan pentad repeat domain-containing protein. (409 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
	TREX1	Three prime repair exonuclease 1. (280 aa)
	POLR3H	RNA polymerase III subunit H. (204 aa)
	ADAR	Adenosine deaminase RNA specific. (1143 aa)
	CGAS	Cyclic GMP-AMP synthase. (518 aa)
	POLR3C	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (535 aa)
	POLR3GL	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (240 aa)
	POLR1C	RNA polymerase I and III subunit C. (359 aa)
	POLR2F	RNA polymerase II subunit F. (127 aa)
	LOC103099606	C-C motif chemokine. (95 aa)
	LOC100020842	C-C motif chemokine. (156 aa)
	CCL5	C-C motif chemokine ligand 5. (91 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (995 aa)
	POLR1D	RNA polymerase I and III subunit D. (115 aa)
	F7G5T5_MONDO	Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
	LOC100032592	Uncharacterized protein; Belongs to the peptidase C14A family. (375 aa)
	LOC100021467	Uncharacterized protein. (183 aa)
	LOC100021258	Type I interferon 1. (198 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	LOC100017283	C-C motif chemokine. (91 aa)
	LOC100017328	C-C motif chemokine. (95 aa)
	LOC103096087	Uncharacterized protein. (398 aa)
	POLR2H	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	IFN7	Type I interferon 7. (183 aa)
	LOC103102395	Uncharacterized protein. (207 aa)
	MAVS	CARD_2 domain-containing protein. (478 aa)
	POLR3K	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (400 aa)
	IFN4	Type I interferon 4. (183 aa)
	LOC100021368	Uncharacterized protein. (183 aa)
	POLR3G	Uncharacterized protein. (267 aa)
	POLR3E	RNA polymerase III subunit E. (709 aa)
	LOC103101367	Uncharacterized protein. (211 aa)
	IFN2	Type I interferon 2. (183 aa)
	POLR2K	Uncharacterized protein. (58 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL5	IL1B	ENSMODP00000023864	ENSMODP00000017267	C-C motif chemokine ligand 5.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.642
CCL5	IL6	ENSMODP00000023864	ENSMODP00000001520	C-C motif chemokine ligand 5.	Uncharacterized protein.	0.690
CCL5	IRF3	ENSMODP00000023864	ENSMODP00000017015	C-C motif chemokine ligand 5.	IRF tryptophan pentad repeat domain-containing protein.	0.429
CCL5	LOC100017283	ENSMODP00000023864	ENSMODP00000038527	C-C motif chemokine ligand 5.	C-C motif chemokine.	0.620
CCL5	LOC100017328	ENSMODP00000023864	ENSMODP00000038528	C-C motif chemokine ligand 5.	C-C motif chemokine.	0.565
CCL5	LOC100021258	ENSMODP00000023864	ENSMODP00000037231	C-C motif chemokine ligand 5.	Type I interferon 1.	0.406
CCL5	LOC103101367	ENSMODP00000023864	ENSMODP00000058784	C-C motif chemokine ligand 5.	Uncharacterized protein.	0.436
CCL5	LOC103102395	ENSMODP00000023864	ENSMODP00000050860	C-C motif chemokine ligand 5.	Uncharacterized protein.	0.439
CCL5	MAVS	ENSMODP00000023864	ENSMODP00000054135	C-C motif chemokine ligand 5.	CARD_2 domain-containing protein.	0.461
CCL5	NFKB1	ENSMODP00000023864	ENSMODP00000025861	C-C motif chemokine ligand 5.	Nuclear factor kappa B subunit 1.	0.937
CCL5	RELA	ENSMODP00000023864	ENSMODP00000011996	C-C motif chemokine ligand 5.	RELA proto-oncogene, NF-kB subunit.	0.916
CGAS	IKBKE	ENSMODP00000023129	ENSMODP00000002458	Cyclic GMP-AMP synthase.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.531
CGAS	IRF3	ENSMODP00000023129	ENSMODP00000017015	Cyclic GMP-AMP synthase.	IRF tryptophan pentad repeat domain-containing protein.	0.606
CGAS	LOC100021258	ENSMODP00000023129	ENSMODP00000037231	Cyclic GMP-AMP synthase.	Type I interferon 1.	0.459
CGAS	LOC103096087	ENSMODP00000023129	ENSMODP00000039043	Cyclic GMP-AMP synthase.	Uncharacterized protein.	0.621
CGAS	MAVS	ENSMODP00000023129	ENSMODP00000054135	Cyclic GMP-AMP synthase.	CARD_2 domain-containing protein.	0.514
CGAS	STING1	ENSMODP00000023129	ENSMODP00000014772	Cyclic GMP-AMP synthase.	Transmembrane protein 173.	0.646
CHUK	IKBKB	ENSMODP00000013213	ENSMODP00000012792	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.999
CHUK	IKBKE	ENSMODP00000013213	ENSMODP00000002458	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.673
CHUK	IKBKG	ENSMODP00000013213	ENSMODP00000011449	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.977