STRINGSTRING
PLCG1 PLCG1 RAC2 RAC2 LOC100015157 LOC100015157 PIK3R3 PIK3R3 SHC4 SHC4 CD247 CD247 PTPN11 PTPN11 RAC3 RAC3 ZAP70 ZAP70 IFN3 IFN3 LOC100021419 LOC100021419 SH3BP2 SH3BP2 PRKCA PRKCA CASP3 CASP3 PAK1 PAK1 FCER1G FCER1G RAF1 RAF1 LCP2 LCP2 GRB2 GRB2 SOS1 SOS1 LOC103100524 LOC103100524 ICAM2 ICAM2 PPP3CC PPP3CC MAP2K1 MAP2K1 SOS2 SOS2 SHC3 SHC3 SH2D1A SH2D1A PLCG2 PLCG2 MAPK3 MAPK3 SHC1 SHC1 LCK LCK MAPK1 MAPK1 PTPN6 PTPN6 F7FNN8_MONDO F7FNN8_MONDO PIK3R1 PIK3R1 PPP3CA PPP3CA IFNGR2 IFNGR2 PIK3CA PIK3CA VAV1 VAV1 BRAF BRAF LOC100021467 LOC100021467 LOC100021258 LOC100021258 KRAS-2 KRAS-2 K7DYV5_MONDO K7DYV5_MONDO CD244 CD244 ITGB2 ITGB2 PRF1 PRF1 PPP3CB PPP3CB PRKCB PRKCB IFNAR2 IFNAR2 LOC654275 LOC654275 NFATC1 NFATC1 IFN7 IFN7 NRAS NRAS ARAF ARAF NFATC2 NFATC2 PIK3CB PIK3CB LOC100015759 LOC100015759 VAV3 VAV3 TNFSF10 TNFSF10 IFN4 IFN4 SYK SYK LOC100021368 LOC100021368 SIRT6 SIRT6 IFNGR1 IFNGR1 ITGAL ITGAL SH2D1B SH2D1B IFN2 IFN2 KLRK1 KLRK1 HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
RAC2Rac family small GTPase 2. (281 aa)
LOC100015157Uncharacterized protein. (238 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
SHC4SHC adaptor protein 4. (678 aa)
CD247CD247 molecule. (166 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
RAC3Rac family small GTPase 3. (192 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
IFN3Uncharacterized protein. (184 aa)
LOC100021419Type I interferon 5. (184 aa)
SH3BP2SH3 domain binding protein 2. (539 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
CASP3Caspase-3-like protein 1; Belongs to the peptidase C14A family. (276 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
FCER1GFc fragment of IgE receptor Ig. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
LCP2SH2 domain-containing protein. (319 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
LOC103100524Uncharacterized protein. (408 aa)
ICAM2ICAM_N domain-containing protein. (276 aa)
PPP3CCSerine/threonine-protein phosphatase. (517 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
SHC3SHC adaptor protein 3. (602 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (123 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
SHC1SHC adaptor protein 1. (577 aa)
LCKTyrosine-protein kinase. (686 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IFNGR2Uncharacterized protein. (344 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
LOC100021467Uncharacterized protein. (183 aa)
LOC100021258Type I interferon 1. (198 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
K7DYV5_MONDOIg-like domain-containing protein. (295 aa)
CD244Ig-like domain-containing protein. (377 aa)
ITGB2Integrin beta. (792 aa)
PRF1Perforin 1. (559 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
IFNAR2Uncharacterized protein. (511 aa)
LOC654275Caspase-3-like protein 2; Belongs to the peptidase C14A family. (276 aa)
NFATC1Nuclear factor of activated T cells 1. (950 aa)
IFN7Type I interferon 7. (183 aa)
NRASGTPase NRas. (195 aa)
ARAFUncharacterized protein. (198 aa)
NFATC2Nuclear factor of activated T cells 2. (927 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
LOC100015759Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (259 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (301 aa)
IFN4Type I interferon 4. (183 aa)
SYKTyrosine-protein kinase. (588 aa)
LOC100021368Uncharacterized protein. (183 aa)
SIRT6Uncharacterized protein. (547 aa)
IFNGR1Fibronectin type-III domain-containing protein. (503 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1126 aa)
SH2D1BSH2 domain-containing protein. (144 aa)
IFN2Type I interferon 2. (183 aa)
KLRK1C-type lectin domain-containing protein. (238 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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