(38 nodes) Intestinal immune network for IgA production network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL6	Uncharacterized protein. (220 aa)
	IL10	Interleukin 10. (173 aa)
	PIGR	Uncharacterized protein. (844 aa)
	TNFRSF17	BCMA-Tall_bind domain-containing protein. (184 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (286 aa)
	MADCAM1	Uncharacterized protein. (438 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	CXCL12	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (89 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
	CCR9	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (336 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (137 aa)
	LOC100026858	Ig-like domain-containing protein. (262 aa)
	LOC100026112	Ig-like domain-containing protein; Belongs to the MHC class II family. (256 aa)
	LOC100026007	Ig-like domain-containing protein; Belongs to the MHC class II family. (256 aa)
	CCR10	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	AICDA	Activation induced cytidine deaminase. (195 aa)
	LTBR	Lymphotoxin beta receptor. (431 aa)
	CD80	Uncharacterized protein. (337 aa)
	CD28	CD28 molecule. (221 aa)
	CD86	Uncharacterized protein. (238 aa)
	LOC100025909	Ig-like domain-containing protein. (282 aa)
	TNFSF13	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (249 aa)
	K7DYV5_MONDO	Ig-like domain-containing protein. (295 aa)
	CCL25	SCY domain-containing protein. (138 aa)
	LOC100027399	Uncharacterized protein. (304 aa)
	MAP3K14	Uncharacterized protein. (1744 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (183 aa)
	CCL28	SCY domain-containing protein. (172 aa)
	LOC100025932	Ig-like domain-containing protein; Belongs to the MHC class II family. (264 aa)
	ENSMODP00000045162	Ig-like domain-containing protein; Belongs to the MHC class II family. (276 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (287 aa)
	CXCR4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	ENSMODP00000047908	Ig-like domain-containing protein; Belongs to the MHC class II family. (267 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (251 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (142 aa)
	F7BIP4_MONDO	Ig-like domain-containing protein. (182 aa)
	IL15RA	Sushi domain-containing protein. (295 aa)
	LOC100026891	Ig-like domain-containing protein. (270 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AICDA	CD40LG	ENSMODP00000022451	ENSMODP00000048298	Activation induced cytidine deaminase.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.682
AICDA	CXCR4	ENSMODP00000022451	ENSMODP00000045752	Activation induced cytidine deaminase.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.425
AICDA	TNFSF13B	ENSMODP00000022451	ENSMODP00000006237	Activation induced cytidine deaminase.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.403
CCL25	CCL28	ENSMODP00000039188	ENSMODP00000042326	SCY domain-containing protein.	SCY domain-containing protein.	0.489
CCL25	CCR10	ENSMODP00000039188	ENSMODP00000018741	SCY domain-containing protein.	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	0.836
CCL25	CCR9	ENSMODP00000039188	ENSMODP00000014255	SCY domain-containing protein.	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	0.991
CCL25	CXCL12	ENSMODP00000039188	ENSMODP00000012487	SCY domain-containing protein.	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.976
CCL25	CXCR4	ENSMODP00000039188	ENSMODP00000045752	SCY domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.868
CCL28	CCL25	ENSMODP00000042326	ENSMODP00000039188	SCY domain-containing protein.	SCY domain-containing protein.	0.489
CCL28	CCR10	ENSMODP00000042326	ENSMODP00000018741	SCY domain-containing protein.	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	0.983
CCL28	CCR9	ENSMODP00000042326	ENSMODP00000014255	SCY domain-containing protein.	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	0.819
CCL28	CXCL12	ENSMODP00000042326	ENSMODP00000012487	SCY domain-containing protein.	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.963
CCL28	CXCR4	ENSMODP00000042326	ENSMODP00000045752	SCY domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.749
CCR10	CCL25	ENSMODP00000018741	ENSMODP00000039188	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.836
CCR10	CCL28	ENSMODP00000018741	ENSMODP00000042326	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.983
CCR10	CCR9	ENSMODP00000018741	ENSMODP00000014255	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	0.476
CCR10	CXCL12	ENSMODP00000018741	ENSMODP00000012487	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.885
CCR10	CXCR4	ENSMODP00000018741	ENSMODP00000045752	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.538
CCR9	CCL25	ENSMODP00000014255	ENSMODP00000039188	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.991
CCR9	CCL28	ENSMODP00000014255	ENSMODP00000042326	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.819