(51 nodes) Long-term potentiation network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
	RAP1A	Uncharacterized protein. (177 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	GRM5	Glutamate metabotropic receptor 5. (890 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1242 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (740 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (902 aa)
	ATF4	Activating transcription factor 4. (346 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (517 aa)
	CALML4	Calmodulin like 4. (156 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (771 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (671 aa)
	CREBBP	CREB binding protein. (2456 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
	GRM1	G_PROTEIN_RECEP_F3_4 domain-containing protein. (798 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1463 aa)
	F7FNN8_MONDO	Uncharacterized protein. (199 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	F7D7P9_MONDO	Uncharacterized protein; Belongs to the calmodulin family. (65 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (563 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	KRAS-2	GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
	EP300	E1A binding protein p300. (2454 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (938 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (520 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (733 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (740 aa)
	NRAS	GTPase NRas. (195 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
	ARAF	Uncharacterized protein. (198 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2123 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
	SIRT6	Uncharacterized protein. (547 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1365 aa)
	CAMK2D	Protein kinase domain-containing protein. (145 aa)
	HRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY8	ENSMODP00000045924	ENSMODP00000001732	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY1	CALM1	ENSMODP00000045924	ENSMODP00000003270	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.927
ADCY1	CALML3	ENSMODP00000045924	ENSMODP00000035365	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.907
ADCY1	CALML4	ENSMODP00000045924	ENSMODP00000011783	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.936
ADCY1	CAMK2B	ENSMODP00000045924	ENSMODP00000020201	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.913
ADCY1	CAMK2D	ENSMODP00000045924	ENSMODP00000058916	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.912
ADCY1	F7D7P9_MONDO	ENSMODP00000045924	ENSMODP00000028730	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.915
ADCY1	PRKACA	ENSMODP00000045924	ENSMODP00000048595	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.926
ADCY1	PRKCA	ENSMODP00000045924	ENSMODP00000005108	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.907
ADCY1	PRKCB	ENSMODP00000045924	ENSMODP00000045459	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.907
ADCY8	ADCY1	ENSMODP00000001732	ENSMODP00000045924	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY8	CALM1	ENSMODP00000001732	ENSMODP00000003270	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.933
ADCY8	CALML3	ENSMODP00000001732	ENSMODP00000035365	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.907
ADCY8	CALML4	ENSMODP00000001732	ENSMODP00000011783	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.959
ADCY8	CAMK2B	ENSMODP00000001732	ENSMODP00000020201	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.908
ADCY8	CAMK2D	ENSMODP00000001732	ENSMODP00000058916	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.907
ADCY8	F7D7P9_MONDO	ENSMODP00000001732	ENSMODP00000028730	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.915
ADCY8	GRIN2A	ENSMODP00000001732	ENSMODP00000058189	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.477
ADCY8	GRIN2B	ENSMODP00000001732	ENSMODP00000022701	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.428
ADCY8	PRKACA	ENSMODP00000001732	ENSMODP00000048595	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.928