STRINGSTRING
PLCG1 PLCG1 MATK MATK MAPK7 MAPK7 RAP1A RAP1A PRDM4 PRDM4 SORT1 SORT1 PIK3R3 PIK3R3 SHC4 SHC4 RPS6KA5 RPS6KA5 CALM1 CALM1 PTPN11 PTPN11 JUN JUN NGF NGF RAF1 RAF1 AKT3 AKT3 RAP1B RAP1B GRB2 GRB2 AKT2 AKT2 RIPK2 RIPK2 RPS6KA3 RPS6KA3 SOS1 SOS1 ATF4 ATF4 CALML4 CALML4 MAP2K5 MAP2K5 RELA RELA MAP2K1 MAP2K1 IKBKB IKBKB PRKCD PRKCD SOS2 SOS2 SHC3 SHC3 NFKBIB NFKBIB MAPK13 MAPK13 AKT1 AKT1 NTF4 NTF4 RPS6KA6 RPS6KA6 KIDINS220 KIDINS220 MAP2K7 MAP2K7 PLCG2 PLCG2 MAPK3 MAPK3 CAMK2B CAMK2B ARHGDIG ARHGDIG SHC1 SHC1 MAP3K5 MAP3K5 CRKL CRKL MAPK1 MAPK1 ARHGDIB ARHGDIB FOXO3 FOXO3 IRAK4 IRAK4 NFKBIE NFKBIE F7FNN8_MONDO F7FNN8_MONDO MAP3K1 MAP3K1 PIK3R1 PIK3R1 TRAF6 TRAF6 NFKB1 NFKB1 MAPK10 MAPK10 PIK3CA PIK3CA F7D7P9_MONDO F7D7P9_MONDO MAPK9 MAPK9 CDC42 CDC42 F7CI75_MONDO F7CI75_MONDO IRAK2 IRAK2 BRAF BRAF NTRK3 NTRK3 NTRK2 NTRK2 IRS1 IRS1 CALML3 CALML3 KRAS-2 KRAS-2 NGFR NGFR BAD BAD ABL1 ABL1 PSEN2 PSEN2 RPS6KA2 RPS6KA2 BDNF BDNF RPS6KA1 RPS6KA1 MAPK14 MAPK14 NRAS NRAS SH2B3 SH2B3 BAX BAX PIK3CB PIK3CB MAPK12 MAPK12 FRS2 FRS2 NFKBIA NFKBIA SIRT6 SIRT6 RHOA RHOA MAP3K3 MAP3K3 GAB1 GAB1 ARHGDIA ARHGDIA PSEN1 PSEN1 CAMK2D CAMK2D GSK3B GSK3B NTF3 NTF3 HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
MATKTyrosine-protein kinase. (470 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (778 aa)
RAP1AUncharacterized protein. (177 aa)
PRDM4PR/SET domain 4. (833 aa)
SORT1Sortilin. (693 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
SHC4SHC adaptor protein 4. (678 aa)
RPS6KA5Ribosomal protein S6 kinase. (795 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (238 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (540 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
ATF4Activating transcription factor 4. (346 aa)
CALML4Calmodulin like 4. (156 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
RELARELA proto-oncogene, NF-kB subunit. (543 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
SHC3SHC adaptor protein 3. (602 aa)
NFKBIBNFKB inhibitor beta. (314 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (249 aa)
RPS6KA6Ribosomal protein S6 kinase. (771 aa)
KIDINS220Kinase D interacting substrate 220. (1784 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (546 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (671 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (225 aa)
SHC1SHC adaptor protein 1. (577 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1390 aa)
CRKLUncharacterized protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (206 aa)
FOXO3Fork-head domain-containing protein. (697 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (458 aa)
NFKBIENFKB inhibitor epsilon. (360 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1491 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
NFKB1Nuclear factor kappa B subunit 1. (995 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
F7D7P9_MONDOUncharacterized protein; Belongs to the calmodulin family. (65 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CDC42Cell division cycle 42. (191 aa)
F7CI75_MONDOUncharacterized protein. (223 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (648 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
NTRK2Tyrosine-protein kinase receptor. (750 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
NGFRNerve growth factor receptor. (433 aa)
BADUncharacterized protein. (212 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (285 aa)
RPS6KA1Ribosomal protein S6 kinase. (740 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NRASGTPase NRas. (195 aa)
SH2B3SH2 domain-containing protein. (458 aa)
BAXUncharacterized protein. (296 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
FRS2IRS-type PTB domain-containing protein. (508 aa)
NFKBIAANK_REP_REGION domain-containing protein. (400 aa)
SIRT6Uncharacterized protein. (547 aa)
RHOAUncharacterized protein. (193 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (667 aa)
GAB1GRB2 associated binding protein 1. (743 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (231 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)
CAMK2DProtein kinase domain-containing protein. (145 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (343 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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