STRINGSTRING
PLCB2 PLCB2 GNG12 GNG12 CREB3L3 CREB3L3 KCNJ12 KCNJ12 ADCY8 ADCY8 GNB5 GNB5 GNAI3 GNAI3 ADCY2 ADCY2 PIK3R3 PIK3R3 SLC18A3 SLC18A3 CHAT CHAT SLC5A7 SLC5A7 ADCY4 ADCY4 PRKCA PRKCA PLCB1 PLCB1 ITPR1 ITPR1 GNG10 GNG10 FOS FOS AKT3 AKT3 GNB1 GNB1 CREB3 CREB3 AKT2 AKT2 GNG3 GNG3 CHRM1 CHRM1 PIK3R5 PIK3R5 LOC100027128 LOC100027128 GNG8 GNG8 ATF4 ATF4 MAP2K1 MAP2K1 CHRNA6 CHRNA6 CHRNB4 CHRNB4 GNAQ GNAQ ADCY7 ADCY7 AKT1 AKT1 CREB3L2 CREB3L2 CREB5 CREB5 JAK2 JAK2 MAPK3 MAPK3 ADCY3 ADCY3 CAMK2B CAMK2B ADCY9 ADCY9 PIK3CG PIK3CG ITPR2 ITPR2 CHRNA4 CHRNA4 GNG13 GNG13 KCNJ4 KCNJ4 GNAI1 GNAI1 CREB3L4 CREB3L4 MAPK1 MAPK1 GNB3 GNB3 F7FNN8_MONDO F7FNN8_MONDO GNA11 GNA11 PIK3R1 PIK3R1 KCNJ6 KCNJ6 GNB4 GNB4 PIK3CA PIK3CA KCNJ2 KCNJ2 CHRM5 CHRM5 CHRM2 CHRM2 CHRM3 CHRM3 CACNA1S CACNA1S KCNJ3 KCNJ3 KRAS-2 KRAS-2 GNG7 GNG7 GNG4 GNG4 GNAI2 GNAI2 CREB3L1 CREB3L1 CACNA1A CACNA1A PRKCB PRKCB ADCY1 ADCY1 KCNQ3 KCNQ3 GNGT2 GNGT2 NRAS NRAS PLCB4 PLCB4 PRKACA PRKACA KCNQ2 KCNQ2 ACHE ACHE CACNA1C CACNA1C GNG5 GNG5 CHRNB2 CHRNB2 PIK3CB PIK3CB ITPR3 ITPR3 CHRNA3 CHRNA3 LOC100010184 LOC100010184 KCNQ5 KCNQ5 CAMK2D CAMK2D GNB2 GNB2 CREB1 CREB1 HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (508 aa)
KCNJ12Uncharacterized protein. (430 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
GNB5G protein subunit beta 5. (353 aa)
GNAI3G protein subunit alpha i3. (399 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
SLC18A3Solute carrier family 18 member A3. (529 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (641 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNB1G protein subunit beta 1. (340 aa)
CREB3BZIP domain-containing protein. (370 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (463 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (873 aa)
LOC100027128Uncharacterized protein. (502 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ATF4Activating transcription factor 4. (346 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (496 aa)
CHRNB4Uncharacterized protein. (504 aa)
GNAQG protein subunit alpha q. (359 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (518 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (504 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (671 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1099 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (631 aa)
GNG13G protein subunit gamma 13. (67 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (440 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (360 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
GNB3G protein subunit beta 3. (340 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
GNA11G protein subunit alpha 11. (359 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (422 aa)
GNB4G protein subunit beta 4. (340 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (468 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (585 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (503 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNAI2G protein subunit alpha i2. (315 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (535 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2485 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (750 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
NRASGTPase NRas. (195 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (906 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (620 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2123 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (541 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (505 aa)
LOC100010184Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5. (832 aa)
CAMK2DProtein kinase domain-containing protein. (145 aa)
GNB2G protein subunit beta 2. (367 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: low (18%) [HD]