STRINGSTRING
PLCB2 PLCB2 GNG12 GNG12 CREB3L3 CREB3L3 SLC6A3 SLC6A3 DRD5 DRD5 DRD4 DRD4 GNB5 GNB5 GNAI3 GNAI3 F7E0E8_MONDO F7E0E8_MONDO CALM1 CALM1 PRKCA PRKCA PLCB1 PLCB1 ITPR1 ITPR1 KCNJ5 KCNJ5 GNG10 GNG10 FOS FOS SCN1A SCN1A AKT3 AKT3 GNB1 GNB1 CREB3 CREB3 AKT2 AKT2 KIF5B KIF5B GNG3 GNG3 LOC103102723 LOC103102723 GRIA1 GRIA1 PPP2R5E PPP2R5E GNG8 GNG8 DDC DDC ATF4 ATF4 SLC18A2 SLC18A2 PPP3CC PPP3CC CALML4 CALML4 ATF2 ATF2 SLC18A1 SLC18A1 PPP2R2B PPP2R2B PPP1R1B PPP1R1B PPP2R3C PPP2R3C GNAQ GNAQ MAPK13 MAPK13 AKT1 AKT1 CREB3L2 CREB3L2 PPP2CA PPP2CA PPP2R1B PPP2R1B ATF6B ATF6B GRIA3 GRIA3 CREB5 CREB5 PPP1CB PPP1CB CAMK2B CAMK2B ITPR2 ITPR2 PPP2R2A PPP2R2A GNG13 GNG13 GNAI1 GNAI1 CREB3L4 CREB3L4 GNB3 GNB3 GRIN2B GRIN2B PPP2R3A PPP2R3A PPP2CB PPP2CB COMT COMT PPP2R2D PPP2R2D CLOCK CLOCK PPP3CA PPP3CA MAPK10 MAPK10 PPP2R1A PPP2R1A KCNJ6 KCNJ6 MAOB MAOB MAOA MAOA GNB4 GNB4 GNAL GNAL F7D7P9_MONDO F7D7P9_MONDO MAPK9 MAPK9 DRD1 DRD1 CALML3 CALML3 KCNJ3 KCNJ3 GNG7 GNG7 GNG4 GNG4 GNAI2 GNAI2 CREB3L1 CREB3L1 CACNA1A CACNA1A PPP3CB PPP3CB PRKCB PRKCB PPP1CC PPP1CC GNGT2 GNGT2 MAPK14 MAPK14 PLCB4 PLCB4 PRKACA PRKACA CACNA1C CACNA1C GNG5 GNG5 PPP2R5D PPP2R5D ARNTL ARNTL KIF5C KIF5C MAPK12 MAPK12 ITPR3 ITPR3 PPP2R5A PPP2R5A LOC100010184 LOC100010184 KCNJ9 KCNJ9 PPP2R3B PPP2R3B GRIN2A GRIN2A GRIA4 GRIA4 ENSMODP00000058393 ENSMODP00000058393 CAMK2D CAMK2D GNB2 GNB2 CREB1 CREB1 GSK3B GSK3B ENSMODP00000059741 ENSMODP00000059741 GNAS GNAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (508 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (709 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (478 aa)
DRD4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
GNB5G protein subunit beta 5. (353 aa)
GNAI3G protein subunit alpha i3. (399 aa)
F7E0E8_MONDOBH4_AAA_HYDROXYL_2 domain-containing protein. (391 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (418 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNB1G protein subunit beta 1. (340 aa)
CREB3BZIP domain-containing protein. (370 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (966 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC103102723Uncharacterized protein. (258 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (902 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
DDCDopa decarboxylase. (515 aa)
ATF4Activating transcription factor 4. (346 aa)
SLC18A2Solute carrier family 18 member A2. (514 aa)
PPP3CCSerine/threonine-protein phosphatase. (517 aa)
CALML4Calmodulin like 4. (156 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SLC18A1Solute carrier family 18 member A1. (526 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (484 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (207 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (449 aa)
GNAQG protein subunit alpha q. (359 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (518 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (627 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (919 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (504 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (671 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (419 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (360 aa)
GNB3G protein subunit beta 3. (340 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1463 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1155 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (260 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (417 aa)
CLOCKClock circadian regulator. (858 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (410 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (422 aa)
MAOBAmine oxidase. (520 aa)
MAOAAmine oxidase. (553 aa)
GNB4G protein subunit beta 4. (340 aa)
GNALG protein subunit alpha L. (379 aa)
F7D7P9_MONDOUncharacterized protein; Belongs to the calmodulin family. (65 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (447 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (503 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNAI2G protein subunit alpha i2. (315 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (535 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2485 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2123 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (696 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (992 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (496 aa)
LOC100010184Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (446 aa)
PPP2R3BEF-hand domain-containing protein. (581 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1365 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (854 aa)
ENSMODP00000058393Arrestin_N domain-containing protein. (120 aa)
CAMK2DProtein kinase domain-containing protein. (145 aa)
GNB2G protein subunit beta 2. (367 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
ENSMODP00000059741Uncharacterized protein. (70 aa)
GNASUncharacterized protein. (370 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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