STRINGSTRING
GNA12 GNA12 SRC SRC PAK6 PAK6 CYFIP1 CYFIP1 RAC2 RAC2 GNG12 GNG12 PDGFD PDGFD MYH9 MYH9 ARPC1A ARPC1A ARPC1B ARPC1B ITGB8 ITGB8 MYLPF MYLPF PDGFC PDGFC PIK3R3 PIK3R3 LOC100016794 LOC100016794 ITGAM ITGAM PIP5K1B PIP5K1B RAC3 RAC3 FGF16 FGF16 LPAR1 LPAR1 FGF19 FGF19 FGF4 FGF4 GNA13 GNA13 LPAR2 LPAR2 PAK5 PAK5 PAK1 PAK1 APC2 APC2 ARPC4 ARPC4 ITGB6 ITGB6 PFN1 PFN1 CFL2 CFL2 BRK1 BRK1 MYL5 MYL5 RAF1 RAF1 F6PU44_MONDO F6PU44_MONDO ARPC5 ARPC5 CHRM1 CHRM1 MYH10 MYH10 FGFR2 FGFR2 SOS1 SOS1 ITGA6 ITGA6 PIP4K2A PIP4K2A EGFR EGFR ITGA11 ITGA11 PDGFB PDGFB LIMK2 LIMK2 FGF17 FGF17 SSH2 SSH2 MAP2K1 MAP2K1 PDGFRB PDGFRB CXCL12 CXCL12 ITGA8 ITGA8 ITGA4 ITGA4 FGFR1 FGFR1 ITGAV ITGAV ITGB3 ITGB3 MYL2 MYL2 ITGA2B ITGA2B F6U132_MONDO F6U132_MONDO SOS2 SOS2 LOC100028958 LOC100028958 PIP4K2B PIP4K2B BDKRB1 BDKRB1 MYLK3 MYLK3 ARHGEF12 ARHGEF12 APC APC ITGA9 ITGA9 F2R F2R LIMK1 LIMK1 ARHGEF6 ARHGEF6 SLC9A1 SLC9A1 RDX RDX WASL WASL ARPC2 ARPC2 PPP1CB PPP1CB MAPK3 MAPK3 KNG1 KNG1 PIKFYVE PIKFYVE MYL7 MYL7 TMSB4X TMSB4X CRKL CRKL MAPK1 MAPK1 LPAR5 LPAR5 FGF23 FGF23 MYLK MYLK ITGB5 ITGB5 PAK2 PAK2 MRAS MRAS ARHGEF4 ARHGEF4 PIP5K1A PIP5K1A FGF2 FGF2 FGF20 FGF20 F7FNN8_MONDO F7FNN8_MONDO ITGA1 ITGA1 ITGA2 ITGA2 GSN GSN PIK3R1 PIK3R1 ARPC5L ARPC5L F2 F2 PPP1R12A PPP1R12A PDGFRA PDGFRA FGF5 FGF5 LOC103103209 LOC103103209 PFN2 PFN2 PIK3CA PIK3CA LPAR4 LPAR4 LOC100016601 LOC100016601 CYFIP2 CYFIP2 SCIN SCIN WASF2 WASF2 CDC42 CDC42 VAV1 VAV1 F7CI75_MONDO F7CI75_MONDO IQGAP3 IQGAP3 CHRM5 CHRM5 BRAF BRAF CHRM2 CHRM2 CHRM3 CHRM3 ENAH ENAH MOS MOS LOC100020439 LOC100020439 EGF EGF KRAS-2 KRAS-2 MSN MSN ITGB1 ITGB1 IQGAP1 IQGAP1 FGF3 FGF3 NCKAP1 NCKAP1 ITGB4 ITGB4 FGD1 FGD1 MYL9 MYL9 FGFR4 FGFR4 ITGB2 ITGB2 SPATA13 SPATA13 INSRR INSRR BAIAP2 BAIAP2 ACTG1 ACTG1 ITGAD ITGAD CXCR4 CXCR4 PDGFA PDGFA PPP1CC PPP1CC MYLK4 MYLK4 MYL10 MYL10 FN1 FN1 RRAS RRAS VCL VCL EZR EZR NRAS NRAS RRAS2 RRAS2 ARAF ARAF FGF1 FGF1 TIAM1 TIAM1 ARHGAP35 ARHGAP35 FGF6 FGF6 DIAPH2 DIAPH2 MYH11 MYH11 DIAPH3 DIAPH3 ARHGEF7 ARHGEF7 PTK2 PTK2 ACTN4 ACTN4 PIK3CB PIK3CB VAV3 VAV3 FGF9 FGF9 LOC100010184 LOC100010184 ROCK1 ROCK1 SIRT6 SIRT6 FGF10 FGF10 ITGAL ITGAL BDKRB2 BDKRB2 MYL12A MYL12A PAK4 PAK4 PFN3 PFN3 FGF18 FGF18 RHOA RHOA ABI2 ABI2 ITGAM-2 ITGAM-2 FGF7 FGF7 HRAS HRAS ROCK2 ROCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNA12G protein subunit alpha 12. (380 aa)
SRCTyrosine-protein kinase. (550 aa)
PAK6P21 (RAC1) activated kinase 6. (592 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
RAC2Rac family small GTPase 2. (281 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (367 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (765 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (180 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
LOC100016794VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1166 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1076 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (556 aa)
RAC3Rac family small GTPase 3. (192 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
GNA13G protein subunit alpha 13. (377 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (342 aa)
PAK5Non-specific serine/threonine protein kinase. (812 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
APC2APC_N_CC domain-containing protein. (1586 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
CFL2ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (195 aa)
BRK1Uncharacterized protein. (106 aa)
MYL5Myosin light chain 5. (170 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
F6PU44_MONDODHR-2 domain-containing protein; Belongs to the DOCK family. (930 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (304 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (463 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2047 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1075 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
LIMK2LIM domain kinase 2. (684 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
SSH2Slingshot protein phosphatase 2. (1424 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet derived growth factor receptor beta. (1061 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (89 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
FGFR1Fibroblast growth factor receptor. (809 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1058 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
MYL2Myosin light chain 2. (166 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1044 aa)
F6U132_MONDOActin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (176 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
LOC100028958Uncharacterized protein. (375 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
BDKRB1Bradykinin receptor B1. (325 aa)
MYLK3Myosin light chain kinase 3. (846 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1539 aa)
APCAPC regulator of WNT signaling pathway. (2936 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1017 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
LIMK1LIM domain kinase 1. (602 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (777 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (392 aa)
RDXRadixin. (598 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (330 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
KNG1Uncharacterized protein. (618 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2090 aa)
MYL7Myosin light chain 7. (175 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
CRKLUncharacterized protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (370 aa)
FGF23Fibroblast growth factor 23. (193 aa)
MYLKMyosin light chain kinase. (1948 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
PAK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
ARHGEF4Uncharacterized protein. (1499 aa)
PIP5K1APIPK domain-containing protein. (630 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1178 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
GSNGelsolin. (776 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (158 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (878 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
FGF5Uncharacterized protein. (125 aa)
LOC103103209G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (317 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (527 aa)
LOC100016601Uncharacterized protein. (374 aa)
CYFIP2Cytoplasmic FMR1 interacting protein 2. (1138 aa)
SCINUncharacterized protein. (376 aa)
WASF2WASP family member 2. (497 aa)
CDC42Cell division cycle 42. (191 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
F7CI75_MONDOUncharacterized protein. (223 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1631 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (468 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (585 aa)
ENAHENAH actin regulator. (825 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (351 aa)
LOC100020439Uncharacterized protein; Belongs to the actin family. (374 aa)
EGFEpidermal growth factor. (1143 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
MSNMoesin. (574 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (802 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
NCKAP1NCK associated protein 1. (1115 aa)
ITGB4Integrin beta. (1864 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (978 aa)
MYL9Uncharacterized protein. (172 aa)
FGFR4Fibroblast growth factor receptor. (849 aa)
ITGB2Integrin beta. (792 aa)
SPATA13Uncharacterized protein. (1489 aa)
INSRRTyrosine-protein kinase receptor. (1307 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
ACTG1Uncharacterized protein. (375 aa)
ITGADIntegrin subunit alpha D; Belongs to the integrin alpha chain family. (1066 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
MYLK4Protein kinase domain-containing protein. (690 aa)
MYL10Uncharacterized protein. (159 aa)
FN1Fibronectin 1. (2482 aa)
RRASRAS related. (255 aa)
VCLVinculin. (1147 aa)
EZREzrin. (587 aa)
NRASGTPase NRas. (195 aa)
RRAS2Uncharacterized protein. (200 aa)
ARAFUncharacterized protein. (198 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1575 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
DIAPH2Diaphanous related formin 2. (1126 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
DIAPH3Diaphanous related formin 3. (1167 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (869 aa)
PTK2Uncharacterized protein. (161 aa)
ACTN4Actinin alpha 4. (934 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
LOC100010184Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1322 aa)
SIRT6Uncharacterized protein. (547 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1126 aa)
BDKRB2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (381 aa)
MYL12AMyosin light chain 12A. (178 aa)
PAK4Non-specific serine/threonine protein kinase. (616 aa)
PFN3Profilin; Belongs to the profilin family. (163 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
RHOAUncharacterized protein. (193 aa)
ABI2Abl interactor 2. (566 aa)
ITGAM-2VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1177 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1482 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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