STRINGSTRING
PPARGC1A PPARGC1A RHOQ RHOQ PHKG2 PHKG2 CBLB CBLB SOCS3 SOCS3 MKNK1 MKNK1 PIK3R3 PIK3R3 SHC4 SHC4 CALM1 CALM1 FBP2 FBP2 ACACA ACACA FASN FASN PRKAA2 PRKAA2 RPS6 RPS6 PRKAR1A PRKAR1A PPP1R3E PPP1R3E MKNK2 MKNK2 PRKAG2 PRKAG2 HK3 HK3 EIF4E1B EIF4E1B RAF1 RAF1 PYGB PYGB AKT3 AKT3 SLC2A4 SLC2A4 PPP1R3C PPP1R3C RPS6KB1 RPS6KB1 PDE3B PDE3B GRB2 GRB2 RPS6KB2 RPS6KB2 AKT2 AKT2 INPPL1 INPPL1 EXOC7 EXOC7 PRKAR1B PRKAR1B SOS1 SOS1 CALML4 CALML4 MAP2K1 MAP2K1 IKBKB IKBKB FOXO1 FOXO1 HK1 HK1 HKDC1 HKDC1 HK2 HK2 SOS2 SOS2 TSC1 TSC1 CBL CBL LIPE LIPE SHC3 SHC3 PRKAR2A PRKAR2A AKT1 AKT1 INSR INSR PRKAB1 PRKAB1 PRKAG3 PRKAG3 PPP1CB PPP1CB MAPK3 MAPK3 PRKAG1 PRKAG1 FLOT1 FLOT1 PPP1R3A PPP1R3A TSC2 TSC2 PRKCI PRKCI PTPN1 PTPN1 PRKAR2B PRKAR2B PCK1 PCK1 F6VMH3_MONDO F6VMH3_MONDO PKLR PKLR PHKA2 PHKA2 SHC1 SHC1 CRKL CRKL MAPK1 MAPK1 GYS2 GYS2 PPP1R3B PPP1R3B F7FNN8_MONDO F7FNN8_MONDO FLOT2 FLOT2 PIK3R1 PIK3R1 PRKAA1 PRKAA1 EIF4E EIF4E MAPK10 MAPK10 PIK3CA PIK3CA LOC100617582 LOC100617582 EIF4E2 EIF4E2 F7D7P9_MONDO F7D7P9_MONDO PPP1R3D PPP1R3D MAPK9 MAPK9 G6PC3 G6PC3 BRAF BRAF IRS1 IRS1 CALML3 CALML3 F6TU13_MONDO F6TU13_MONDO IRS2 IRS2 KRAS-2 KRAS-2 PPP1R3F PPP1R3F K7E1M2_MONDO K7E1M2_MONDO GYS1 GYS1 G6PC G6PC PRKCZ PRKCZ PHKA1-2 PHKA1-2 BAD BAD PPP1CC PPP1CC GCK GCK NRAS NRAS PRKACA PRKACA ARAF ARAF PYGL PYGL PHKB PHKB PRKAB2 PRKAB2 RPTOR RPTOR PCK2 PCK2 EIF4EBP1 EIF4EBP1 PIK3CB PIK3CB PHKG1 PHKG1 SIRT6 SIRT6 RHEB RHEB MTOR MTOR PYGM PYGM SOCS2 SOCS2 FBP1 FBP1 SOCS4 SOCS4 GSK3B GSK3B HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARGC1APPARG coactivator 1 alpha. (795 aa)
RHOQRas homolog family member Q. (205 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (405 aa)
CBLBCbl proto-oncogene B. (983 aa)
SOCS3Suppressor of cytokine signaling 3. (235 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (423 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
SHC4SHC adaptor protein 4. (678 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (340 aa)
ACACAAcetyl-CoA carboxylase alpha. (2288 aa)
FASNFatty acid synthase. (2512 aa)
PRKAA2Non-specific serine/threonine protein kinase. (551 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (385 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (285 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (453 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (580 aa)
HK3Hexokinase 3. (1049 aa)
EIF4E1BUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
PDE3BPhosphodiesterase. (1156 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (476 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1013 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (488 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
CALML4Calmodulin like 4. (156 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
FOXO1Forkhead box O1. (670 aa)
HK1Hexokinase 1. (922 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK2Hexokinase 2. (932 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
TSC1TSC complex subunit 1. (1152 aa)
CBLCbl proto-oncogene. (837 aa)
LIPEHSL_N domain-containing protein. (664 aa)
SHC3SHC adaptor protein 3. (602 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (392 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
PRKAB1AMPKBI domain-containing protein. (273 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (471 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (310 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (420 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1214 aa)
TSC2TSC complex subunit 2. (1830 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (579 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (391 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (419 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
F6VMH3_MONDOUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (169 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (569 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1236 aa)
SHC1SHC adaptor protein 1. (577 aa)
CRKLUncharacterized protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (700 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (504 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (235 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100617582Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1107 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (248 aa)
F7D7P9_MONDOUncharacterized protein; Belongs to the calmodulin family. (65 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D. (300 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
F6TU13_MONDOProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
IRS2Insulin receptor substrate 2. (1384 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
PPP1R3FCBM21 domain-containing protein. (686 aa)
K7E1M2_MONDOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1138 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (690 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (589 aa)
PHKA1-2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (216 aa)
BADUncharacterized protein. (212 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
GCKPhosphotransferase. (532 aa)
NRASGTPase NRas. (195 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
ARAFUncharacterized protein. (198 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (863 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (996 aa)
PRKAB2AMPKBI domain-containing protein. (106 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1225 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (553 aa)
EIF4EBP1Uncharacterized protein. (273 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
PHKG1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (387 aa)
SIRT6Uncharacterized protein. (547 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1007 aa)
SOCS2Suppressor of cytokine signaling 2. (234 aa)
FBP1FBPase domain-containing protein; Belongs to the FBPase class 1 family. (338 aa)
SOCS4Suppressor of cytokine signaling 4. (436 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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