120 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SRC	Tyrosine-protein kinase. (550 aa)
	PGR	Progesterone receptor. (950 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (508 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
	GABBR2	Gamma-aminobutyric acid type B receptor subunit 2. (916 aa)
	GNAI3	G protein subunit alpha i3. (399 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
	PIK3R3	SH2 domain-containing protein. (276 aa)
	SHC4	SHC adaptor protein 4. (678 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
	KCNJ5	Potassium voltage-gated channel subfamily J member 5. (418 aa)
	EBAG9	Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa)
	HSPA1A	Uncharacterized protein; Belongs to the heat shock protein 70 family. (722 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	CREB3	BZIP domain-containing protein. (370 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	NCOA2	Nuclear receptor coactivator. (1462 aa)
	AKT2	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
	OPRM1	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (401 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	EGFR	Receptor protein-tyrosine kinase. (1213 aa)
	ESR2	Estrogen receptor 2. (533 aa)
	ATF4	Activating transcription factor 4. (346 aa)
	CALML4	Calmodulin like 4. (156 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
	TGFA	Transforming growth factor alpha. (159 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
	MMP2	Matrix metallopeptidase 2. (688 aa)
	KRT24	IF rod domain-containing protein; Belongs to the intermediate filament family. (498 aa)
	HSP90AA1	HATPase_c domain-containing protein. (731 aa)
	SHC3	SHC adaptor protein 3. (602 aa)
	KRT25	Keratin 25; Belongs to the intermediate filament family. (445 aa)
	KRT26	Keratin 26; Belongs to the intermediate filament family. (466 aa)
	KRT28	IF rod domain-containing protein; Belongs to the intermediate filament family. (474 aa)
	LOC100015328	IF rod domain-containing protein; Belongs to the intermediate filament family. (495 aa)
	LOC100015328-2	IF rod domain-containing protein; Belongs to the intermediate filament family. (491 aa)
	KRT12	Keratin 12; Belongs to the intermediate filament family. (496 aa)
	KRT20	Keratin 20; Belongs to the intermediate filament family. (423 aa)
	KRT23	Keratin 23; Belongs to the intermediate filament family. (420 aa)
	KRT39	IF rod domain-containing protein; Belongs to the intermediate filament family. (503 aa)
	KRT40	Keratin 40; Belongs to the intermediate filament family. (431 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	MMP9	Matrix metallopeptidase 9. (709 aa)
	FKBP5	Peptidylprolyl isomerase. (459 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (518 aa)
	LOC100013846	IF rod domain-containing protein; Belongs to the intermediate filament family. (458 aa)
	LOC100013884	IF rod domain-containing protein; Belongs to the intermediate filament family. (443 aa)
	KRT32	Keratin 32; Belongs to the intermediate filament family. (451 aa)
	KRT35	Keratin 35; Belongs to the intermediate filament family. (455 aa)
	KRT36	Keratin 36; Belongs to the intermediate filament family. (462 aa)
	LOC100013532	IF rod domain-containing protein; Belongs to the intermediate filament family. (599 aa)
	LOC100618392	IF rod domain-containing protein; Belongs to the intermediate filament family. (452 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (504 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	POMC	Proopiomelanocortin. (272 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	GABBR1	Gamma-aminobutyric acid type B receptor subunit 1. (579 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
	GRM1	G_PROTEIN_RECEP_F3_4 domain-containing protein. (798 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	SHC1	SHC adaptor protein 1. (577 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (360 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	FKBP4	Peptidylprolyl isomerase. (462 aa)
	HSP90AB1	Uncharacterized protein. (362 aa)
	F7FNN8_MONDO	Uncharacterized protein. (199 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
	KCNJ6	Potassium voltage-gated channel subfamily J member 6. (422 aa)
	TFF1	P-type domain-containing protein. (91 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	F7D7P9_MONDO	Uncharacterized protein; Belongs to the calmodulin family. (65 aa)
	LOC100013604	IF rod domain-containing protein; Belongs to the intermediate filament family. (439 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	KCNJ3	Potassium voltage-gated channel subfamily J member 3. (503 aa)
	LOC100011711	Uncharacterized protein; Belongs to the heat shock protein 70 family. (644 aa)
	LOC100015032	Uncharacterized protein; Belongs to the heat shock protein 70 family. (644 aa)
	KRAS-2	GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
	KRT24-2	IF rod domain-containing protein; Belongs to the intermediate filament family. (429 aa)
	LOC100015637	IF rod domain-containing protein; Belongs to the intermediate filament family. (414 aa)
	LOC100019349	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (136 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (835 aa)
	GNAI2	G protein subunit alpha i2. (315 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (535 aa)
	RARA	Retinoic acid receptor alpha. (464 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
	KRT14	IF rod domain-containing protein; Belongs to the intermediate filament family. (479 aa)
	NRAS	GTPase NRas. (195 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
	KRT17	Keratin 17; Belongs to the intermediate filament family. (437 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
	LOC100013969	IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (648 aa)
	SIRT6	Uncharacterized protein. (547 aa)
	KCNJ9	Potassium voltage-gated channel subfamily J member 9. (446 aa)
	LOC100619044	IF rod domain-containing protein; Belongs to the intermediate filament family. (465 aa)
	LOC100014812	IF rod domain-containing protein; Belongs to the intermediate filament family. (453 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	ENSMODP00000059741	Uncharacterized protein. (70 aa)
	GNAS	Uncharacterized protein. (370 aa)
	HRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	KRT9	IF rod domain-containing protein; Belongs to the intermediate filament family. (372 aa)
	LOC100013082	IF rod domain-containing protein; Belongs to the intermediate filament family. (423 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSMODP00000045924	ENSMODP00000002517	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.464
ADCY1	ADCY3	ENSMODP00000045924	ENSMODP00000019825	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.943
ADCY1	ADCY4	ENSMODP00000045924	ENSMODP00000003686	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.435
ADCY1	ADCY7	ENSMODP00000045924	ENSMODP00000016328	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.495
ADCY1	ADCY8	ENSMODP00000045924	ENSMODP00000001732	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY1	ADCY9	ENSMODP00000045924	ENSMODP00000020470	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.661
ADCY1	AKT1	ENSMODP00000045924	ENSMODP00000017125	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.694
ADCY1	AKT2	ENSMODP00000045924	ENSMODP00000009476	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	0.694
ADCY1	AKT3	ENSMODP00000045924	ENSMODP00000008221	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.694
ADCY1	CALM1	ENSMODP00000045924	ENSMODP00000003270	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.927
ADCY1	CALML3	ENSMODP00000045924	ENSMODP00000035365	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.907
ADCY1	CALML4	ENSMODP00000045924	ENSMODP00000011783	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.936
ADCY1	ENSMODP00000059741	ENSMODP00000045924	ENSMODP00000059741	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.960
ADCY1	F7D7P9_MONDO	ENSMODP00000045924	ENSMODP00000028730	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.915
ADCY1	GNAI1	ENSMODP00000045924	ENSMODP00000021359	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.802
ADCY1	GNAI2	ENSMODP00000045924	ENSMODP00000041761	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.802
ADCY1	GNAI3	ENSMODP00000045924	ENSMODP00000002408	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.798
ADCY1	GNAS	ENSMODP00000045924	ENSMODP00000059778	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.960
ADCY1	PRKACA	ENSMODP00000045924	ENSMODP00000048595	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.926
ADCY1	PRKCD	ENSMODP00000045924	ENSMODP00000013341	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.903