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PLCB2 PLCB2 CREB3L3 CREB3L3 WNT2B WNT2B ADCY8 ADCY8 EDNRB EDNRB GNAI3 GNAI3 ADCY2 ADCY2 CALM1 CALM1 TYR TYR ASIP ASIP ADCY4 ADCY4 DVL3 DVL3 MITF MITF FZD4 FZD4 PRKCA PRKCA PLCB1 PLCB1 WNT11 WNT11 FZD6 FZD6 RAF1 RAF1 DVL1 DVL1 DVL2 DVL2 FZD8 FZD8 CREB3 CREB3 WNT7B WNT7B WNT7A WNT7A FZD3 FZD3 DCT DCT CALML4 CALML4 MAP2K1 MAP2K1 FZD1 FZD1 EDN1 EDN1 CTNNB1 CTNNB1 FZD2 FZD2 GNAQ GNAQ ADCY7 ADCY7 FZD9 FZD9 WNT3A WNT3A CREB3L2 CREB3L2 TYRP1 TYRP1 WNT6 WNT6 WNT16 WNT16 TCF7L1 TCF7L1 MAPK3 MAPK3 WNT2 WNT2 POMC POMC ADCY3 ADCY3 FZD5 FZD5 CAMK2B CAMK2B FZD7 FZD7 ADCY9 ADCY9 CREBBP CREBBP GNAI1 GNAI1 CREB3L4 CREB3L4 MAPK1 MAPK1 WNT5A WNT5A F7FNN8_MONDO F7FNN8_MONDO LEF1 LEF1 F7D7P9_MONDO F7D7P9_MONDO TCF7 TCF7 CALML3 CALML3 KIT KIT WNT10A WNT10A KRAS-2 KRAS-2 EP300 EP300 WNT9B WNT9B GNAI2 GNAI2 WNT3 WNT3 CREB3L1 CREB3L1 MC1R MC1R PRKCB PRKCB KITLG KITLG ADCY1 ADCY1 NRAS NRAS PLCB4 PLCB4 PRKACA PRKACA WNT1 WNT1 TCF7L2 TCF7L2 WNT9A WNT9A WNT5B WNT5B SIRT6 SIRT6 WNT4 WNT4 WNT8B WNT8B CAMK2D CAMK2D CREB1 CREB1 FZD10 FZD10 GSK3B GSK3B ENSMODP00000059741 ENSMODP00000059741 GNAS GNAS HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (508 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (434 aa)
GNAI3G protein subunit alpha i3. (399 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
TYRTyrosinase. (512 aa)
ASIPAgouti signaling protein. (130 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
DVL3Dishevelled segment polarity protein 3. (635 aa)
MITFMelanocyte inducing transcription factor. (418 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
DVL1Dishevelled segment polarity protein 1. (705 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (710 aa)
CREB3BZIP domain-containing protein. (370 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (200 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
DCTDopachrome tautomerase. (526 aa)
CALML4Calmodulin like 4. (156 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
EDN1Endothelin 1. (214 aa)
CTNNB1Catenin beta 1. (781 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
GNAQG protein subunit alpha q. (359 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (518 aa)
TYRP1Tyrosinase related protein 1. (535 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
TCF7L1Transcription factor 7 like 1. (613 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
POMCProopiomelanocortin. (272 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (671 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
CREBBPCREB binding protein. (2456 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (360 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
LEF1Lymphoid enhancer binding factor 1. (401 aa)
F7D7P9_MONDOUncharacterized protein; Belongs to the calmodulin family. (65 aa)
TCF7Transcription factor 7. (442 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
EP300E1A binding protein p300. (2454 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (427 aa)
GNAI2G protein subunit alpha i2. (315 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (535 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (336 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
NRASGTPase NRas. (195 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
TCF7L2Transcription factor 7 like 2. (579 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (447 aa)
SIRT6Uncharacterized protein. (547 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
CAMK2DProtein kinase domain-containing protein. (145 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
ENSMODP00000059741Uncharacterized protein. (70 aa)
GNASUncharacterized protein. (370 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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