STRINGSTRING
PPARGC1A PPARGC1A NPY NPY ADIPOR1 ADIPOR1 LEPR LEPR RXRG RXRG F7BCH7_MONDO F7BCH7_MONDO SOCS3 SOCS3 PTPN11 PTPN11 PRKAA2 PRKAA2 CPT1A CPT1A PRKAG2 PRKAG2 AGRP AGRP TRADD TRADD AKT3 AKT3 SLC2A4 SLC2A4 PPARA PPARA AKT2 AKT2 IKBKG IKBKG RELA RELA IKBKB IKBKB ACSL5 ACSL5 CHUK CHUK CAMKK2 CAMKK2 ADIPOQ ADIPOQ NFKBIB NFKBIB CPT1C CPT1C AKT1 AKT1 ACSL6 ACSL6 RXRB RXRB PRKAB1 PRKAB1 PRKAG3 PRKAG3 JAK2 JAK2 PRKAG1 PRKAG1 POMC POMC PCK1 PCK1 PRKCQ PRKCQ CD36 CD36 SLC2A1 SLC2A1 TRAF2 TRAF2 TNFRSF1A TNFRSF1A ADIPOR2 ADIPOR2 NFKBIE NFKBIE PRKAA1 PRKAA1 NFKB1 NFKB1 MAPK10 MAPK10 ACSL3 ACSL3 MAPK9 MAPK9 G6PC3 G6PC3 IRS1 IRS1 IRS2 IRS2 STK11 STK11 G6PC G6PC LEP LEP ACSL1 ACSL1 ENSMODP00000045933 ENSMODP00000045933 PRKAB2 PRKAB2 PCK2 PCK2 CPT1B CPT1B STAT3 STAT3 NFKBIA NFKBIA MTOR MTOR ACSBG1 ACSBG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARGC1APPARG coactivator 1 alpha. (795 aa)
NPYNeuropeptide Y. (95 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
LEPRUncharacterized protein. (893 aa)
RXRGRetinoid X receptor gamma. (467 aa)
F7BCH7_MONDOAMP-binding domain-containing protein. (651 aa)
SOCS3Suppressor of cytokine signaling 3. (235 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
PRKAA2Non-specific serine/threonine protein kinase. (551 aa)
CPT1ACarn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (300 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (580 aa)
AGRPAgouti related neuropeptide. (147 aa)
TRADDTNFRSF1A associated via death domain. (361 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
RELARELA proto-oncogene, NF-kB subunit. (543 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (683 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CAMKK2Protein kinase domain-containing protein. (322 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (256 aa)
NFKBIBNFKB inhibitor beta. (314 aa)
CPT1CCarn_acyltransf domain-containing protein. (1233 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ACSL6AMP-binding domain-containing protein. (725 aa)
RXRBRetinoid X receptor beta. (530 aa)
PRKAB1AMPKBI domain-containing protein. (273 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (471 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (310 aa)
POMCProopiomelanocortin. (272 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (695 aa)
CD36CD36 molecule; Belongs to the CD36 family. (471 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (633 aa)
TNFRSF1AUncharacterized protein. (453 aa)
ADIPOR2Adiponectin receptor 2. (387 aa)
NFKBIENFKB inhibitor epsilon. (360 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
NFKB1Nuclear factor kappa B subunit 1. (995 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
IRS2Insulin receptor substrate 2. (1384 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (414 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (737 aa)
ENSMODP00000045933AMP-binding domain-containing protein. (654 aa)
PRKAB2AMPKBI domain-containing protein. (106 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (553 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (775 aa)
STAT3Signal transducer and activator of transcription. (805 aa)
NFKBIAANK_REP_REGION domain-containing protein. (400 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (739 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: medium (56%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.