118 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SRC	Tyrosine-protein kinase. (550 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
	EEF2	Tr-type G domain-containing protein. (858 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (778 aa)
	KCNJ12	Uncharacterized protein. (430 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (688 aa)
	GNAI3	G protein subunit alpha i3. (399 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	NFATC4	Nuclear factor of activated T cells 4. (902 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
	TRPM2	LSDAT_euk domain-containing protein. (860 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (551 aa)
	CACNG1	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
	F6Y3Q3_MONDO	Guanylate cyclase. (847 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (580 aa)
	OXTR	Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (397 aa)
	KCNJ5	Potassium voltage-gated channel subfamily J member 5. (418 aa)
	CAMK1	Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (373 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
	NPR2	Guanylate cyclase. (1047 aa)
	EEF2K	Eukaryotic elongation factor 2 kinase. (724 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (873 aa)
	EGFR	Receptor protein-tyrosine kinase. (1213 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (517 aa)
	CALML4	Calmodulin like 4. (156 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	CACNB3	Calcium voltage-gated channel auxiliary subunit beta 3. (482 aa)
	F7FK82_MONDO	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (667 aa)
	NPPA	Natriuretic peptide A. (160 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (608 aa)
	CAMKK2	Protein kinase domain-containing protein. (322 aa)
	LOC100028958	Uncharacterized protein. (375 aa)
	RGS2	Regulator of G protein signaling 2. (211 aa)
	CACNB1	Calcium voltage-gated channel auxiliary subunit beta 1. (605 aa)
	MYLK3	Myosin light chain kinase 3. (846 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
	PLA2G4C	PLA2c domain-containing protein. (204 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	PRKAB1	AMPKBI domain-containing protein. (273 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (471 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (310 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (671 aa)
	CACNG3	Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1099 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
	CAMK1D	Calcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (392 aa)
	KCNJ4	Potassium voltage-gated channel subfamily J member 4. (440 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	NPR1	Guanylate cyclase. (904 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	PLA2G4E	Phospholipase A2. (868 aa)
	MYLK	Myosin light chain kinase. (1948 aa)
	CACNA2D4	VWFA domain-containing protein. (330 aa)
	F7FNN8_MONDO	Uncharacterized protein. (199 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	PPP1R12A	Protein phosphatase 1 regulatory subunit. (878 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	KCNJ6	Potassium voltage-gated channel subfamily J member 6. (422 aa)
	F7D7P9_MONDO	Uncharacterized protein; Belongs to the calmodulin family. (65 aa)
	LOC100016601	Uncharacterized protein. (374 aa)
	KCNJ2	Potassium voltage-gated channel subfamily J member 2. (427 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
	KCNJ3	Potassium voltage-gated channel subfamily J member 3. (503 aa)
	LOC100020439	Uncharacterized protein; Belongs to the actin family. (374 aa)
	KRAS-2	GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
	GNAI2	G protein subunit alpha i2. (315 aa)
	NFATC3	Nuclear factor of activated T cells 3. (1079 aa)
	MYL9	Uncharacterized protein. (172 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (520 aa)
	ACTG1	Uncharacterized protein. (375 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
	RYR2	Ryanodine receptor 2. (4900 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
	MYLK4	Protein kinase domain-containing protein. (690 aa)
	NFATC1	Nuclear factor of activated T cells 1. (950 aa)
	CACNA2D2	Uncharacterized protein. (484 aa)
	NRAS	GTPase NRas. (195 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
	CCND1	Uncharacterized protein. (67 aa)
	CACNB2	Calcium voltage-gated channel auxiliary subunit beta 2. (612 aa)
	RYR3	Ryanodine receptor 3. (4841 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (626 aa)
	NFATC2	Nuclear factor of activated T cells 2. (927 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2123 aa)
	PRKAB2	AMPKBI domain-containing protein. (106 aa)
	CACNA2D3	Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (997 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1322 aa)
	SIRT6	Uncharacterized protein. (547 aa)
	CACNA2D1-2	Uncharacterized protein. (105 aa)
	CD38	Uncharacterized protein. (313 aa)
	RCAN1	Regulator of calcineurin 1. (259 aa)
	RHOA	Uncharacterized protein. (193 aa)
	KCNJ9	Potassium voltage-gated channel subfamily J member 9. (446 aa)
	CAMK2D	Protein kinase domain-containing protein. (145 aa)
	CACNB4	SH3 domain-containing protein. (520 aa)
	F7GAG3_MONDO	PLA2c domain-containing protein. (590 aa)
	ENSMODP00000059741	Uncharacterized protein. (70 aa)
	GNAS	Uncharacterized protein. (370 aa)
	HRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1482 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTG1	MYL9	ENSMODP00000045417	ENSMODP00000043060	Uncharacterized protein.	Uncharacterized protein.	0.934
ACTG1	PPP1CB	ENSMODP00000045417	ENSMODP00000019422	Uncharacterized protein.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.457
ACTG1	PPP1CC	ENSMODP00000045417	ENSMODP00000046390	Uncharacterized protein.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.472
ACTG1	RHOA	ENSMODP00000045417	ENSMODP00000057386	Uncharacterized protein.	Uncharacterized protein.	0.926
ADCY1	ADCY2	ENSMODP00000045924	ENSMODP00000002517	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.464
ADCY1	ADCY3	ENSMODP00000045924	ENSMODP00000019825	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.943
ADCY1	ADCY4	ENSMODP00000045924	ENSMODP00000003686	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.435
ADCY1	ADCY7	ENSMODP00000045924	ENSMODP00000016328	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.495
ADCY1	ADCY8	ENSMODP00000045924	ENSMODP00000001732	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY1	ADCY9	ENSMODP00000045924	ENSMODP00000020470	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.661
ADCY1	CALM1	ENSMODP00000045924	ENSMODP00000003270	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.927
ADCY1	CALML3	ENSMODP00000045924	ENSMODP00000035365	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.907
ADCY1	CALML4	ENSMODP00000045924	ENSMODP00000011783	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.936
ADCY1	CAMK2B	ENSMODP00000045924	ENSMODP00000020201	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.913
ADCY1	CAMK2D	ENSMODP00000045924	ENSMODP00000058916	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.912
ADCY1	EEF2K	ENSMODP00000045924	ENSMODP00000009601	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Eukaryotic elongation factor 2 kinase.	0.428
ADCY1	ENSMODP00000059741	ENSMODP00000045924	ENSMODP00000059741	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.960
ADCY1	F7D7P9_MONDO	ENSMODP00000045924	ENSMODP00000028730	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.915
ADCY1	GNAI1	ENSMODP00000045924	ENSMODP00000021359	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.802
ADCY1	GNAI2	ENSMODP00000045924	ENSMODP00000041761	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.802