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PLCB2 PLCB2 PPARGC1A PPARGC1A CREB3L3 CREB3L3 PHKG2 PHKG2 PKM PKM PPP4R3B PPP4R3B ADCY2 ADCY2 PDHB PDHB CALM1 CALM1 FBP2 FBP2 GCGR GCGR ACACA ACACA PRKAA2 PRKAA2 CPT1A CPT1A PGAM1 PGAM1 PLCB1 PLCB1 ITPR1 ITPR1 PRKAG2 PRKAG2 GCG GCG PYGB PYGB LDHC LDHC LDHA LDHA AKT3 AKT3 CREB3 CREB3 PDE3B PDE3B PPARA PPARA AKT2 AKT2 ATF4 ATF4 PPP3CC PPP3CC CALML4 CALML4 ATF2 ATF2 FOXO1 FOXO1 GNAQ GNAQ CPT1C CPT1C PRMT1 PRMT1 AKT1 AKT1 CREB3L2 CREB3L2 SIK2 SIK2 PRKAB1 PRKAB1 CREB5 CREB5 PRKAG3 PRKAG3 PPP4C PPP4C PRKAG1 PRKAG1 SLC2A2 SLC2A2 CAMK2B CAMK2B CREBBP CREBBP PCK1 PCK1 ITPR2 ITPR2 PHKA2 PHKA2 SLC2A1 SLC2A1 SIRT1 SIRT1 CREB3L4 CREB3L4 LDHB LDHB GYS2 GYS2 PRKAA1 PRKAA1 PPP3CA PPP3CA SIK1 SIK1 F7D7P9_MONDO F7D7P9_MONDO G6PC3 G6PC3 CALML3 CALML3 EP300 EP300 GYS1 GYS1 G6PC G6PC PHKA1-2 PHKA1-2 CREB3L1 CREB3L1 PPP3CB PPP3CB LOC100028279 LOC100028279 PPP4R3A PPP4R3A PFKFB1 PFKFB1 PDHA1 PDHA1 GCK GCK PLCB4 PLCB4 PRKACA PRKACA PYGL PYGL PHKB PHKB PRKAB2 PRKAB2 PCK2 PCK2 CPT1B CPT1B PHKG1 PHKG1 ITPR3 ITPR3 PYGM PYGM CAMK2D CAMK2D FBP1 FBP1 CREB1 CREB1 ENSMODP00000059741 ENSMODP00000059741 GNAS GNAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
PPARGC1APPARG coactivator 1 alpha. (795 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (508 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (405 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (635 aa)
PPP4R3BSMK-1 domain-containing protein. (820 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (371 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (340 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (511 aa)
ACACAAcetyl-CoA carboxylase alpha. (2288 aa)
PRKAA2Non-specific serine/threonine protein kinase. (551 aa)
CPT1ACarn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (300 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (580 aa)
GCGGlucagon. (181 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (318 aa)
LDHAL-lactate dehydrogenase A chain. (332 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CREB3BZIP domain-containing protein. (370 aa)
PDE3BPhosphodiesterase. (1156 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
ATF4Activating transcription factor 4. (346 aa)
PPP3CCSerine/threonine-protein phosphatase. (517 aa)
CALML4Calmodulin like 4. (156 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
FOXO1Forkhead box O1. (670 aa)
GNAQG protein subunit alpha q. (359 aa)
CPT1CCarn_acyltransf domain-containing protein. (1233 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (390 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (518 aa)
SIK2Salt inducible kinase 2. (920 aa)
PRKAB1AMPKBI domain-containing protein. (273 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (504 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (471 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (310 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (518 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (671 aa)
CREBBPCREB binding protein. (2456 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1236 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (713 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (360 aa)
LDHBL-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (378 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (700 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SIK1Uncharacterized protein. (780 aa)
F7D7P9_MONDOUncharacterized protein; Belongs to the calmodulin family. (65 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
EP300E1A binding protein p300. (2454 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (690 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PHKA1-2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (216 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (535 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
LOC100028279L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
PPP4R3AProtein phosphatase 4 regulatory subunit 3A. (833 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (574 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (411 aa)
GCKPhosphotransferase. (532 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (863 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (996 aa)
PRKAB2AMPKBI domain-containing protein. (106 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (553 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (775 aa)
PHKG1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (387 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1007 aa)
CAMK2DProtein kinase domain-containing protein. (145 aa)
FBP1FBPase domain-containing protein; Belongs to the FBPase class 1 family. (338 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
ENSMODP00000059741Uncharacterized protein. (70 aa)
GNASUncharacterized protein. (370 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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