STRINGSTRING
F6S1F1_MONDO F6S1F1_MONDO PLCB2 PLCB2 CREB3L3 CREB3L3 ADCY8 ADCY8 ADCY2 ADCY2 ADCY4 ADCY4 PLCB1 PLCB1 ITPR1 ITPR1 LOC100012668 LOC100012668 LDLR LDLR NR0B1 NR0B1 CREB3 CREB3 AGT AGT ATF4 ATF4 ATF2 ATF2 CYP11A1 CYP11A1 STAR STAR GNAQ GNAQ ADCY7 ADCY7 CREB3L2 CREB3L2 ATF6B ATF6B CYP21A2 CYP21A2 CREB5 CREB5 KCNK3 KCNK3 POMC POMC ADCY3 ADCY3 ADCY9 ADCY9 ITPR2 ITPR2 CREB3L4 CREB3L4 GNA11 GNA11 PDE8A PDE8A NR5A1 NR5A1 MC2R MC2R AGTR1 AGTR1 CACNA1S CACNA1S NCEH1 NCEH1 SCARB1 SCARB1 CREB3L1 CREB3L1 ADCY1 ADCY1 MRAP MRAP PBX1 PBX1 KCNK2 KCNK2 PLCB4 PLCB4 PRKACA PRKACA ORAI1 ORAI1 CACNA1C CACNA1C ITPR3 ITPR3 CACNA1H CACNA1H CREB1 CREB1 CACNA1G CACNA1G ENSMODP00000059741 ENSMODP00000059741 GNAS GNAS KCNA4 KCNA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F6S1F1_MONDOUncharacterized protein; Belongs to the cytochrome P450 family. (429 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (508 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
LOC1000126683Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (377 aa)
LDLRLow density lipoprotein receptor. (906 aa)
NR0B1NR LBD domain-containing protein. (293 aa)
CREB3BZIP domain-containing protein. (370 aa)
AGTAngiotensinogen; Belongs to the serpin family. (469 aa)
ATF4Activating transcription factor 4. (346 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (524 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (338 aa)
GNAQG protein subunit alpha q. (359 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (518 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (484 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (504 aa)
KCNK3Potassium channel subfamily K member. (386 aa)
POMCProopiomelanocortin. (272 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (360 aa)
GNA11G protein subunit alpha 11. (359 aa)
PDE8APhosphodiesterase. (853 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (463 aa)
MC2RMelanocortin 2 receptor. (317 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
NCEH1Uncharacterized protein. (416 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (519 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (535 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
MRAPUncharacterized protein. (167 aa)
PBX1PBX homeobox 1. (430 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (447 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
ORAI1Uncharacterized protein. (314 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2123 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2358 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2345 aa)
ENSMODP00000059741Uncharacterized protein. (70 aa)
GNASUncharacterized protein. (370 aa)
KCNA4Ion_trans domain-containing protein; Belongs to the potassium channel family. (132 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.