93 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GNA12	G protein subunit alpha 12. (380 aa)
	LOC100012635	Uncharacterized protein. (576 aa)
	LOC100012717	Uncharacterized protein. (697 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
	MAFB	MAF bZIP transcription factor B. (379 aa)
	MMP13	Matrix metallopeptidase 13. (475 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (508 aa)
	TRPV5	Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (730 aa)
	PDE4B	Phosphodiesterase. (500 aa)
	RXRG	Retinoid X receptor gamma. (467 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
	MMP24	Matrix metallopeptidase 24. (619 aa)
	GNAI3	G protein subunit alpha i3. (399 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
	SLC34A1	Solute carrier family 34 member 1. (655 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
	MMP14	Matrix metallopeptidase 14. (579 aa)
	PDE4A	Phosphodiesterase. (587 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
	CREB3	BZIP domain-containing protein. (370 aa)
	PTH	Uncharacterized protein. (137 aa)
	EGFR	Receptor protein-tyrosine kinase. (1213 aa)
	ATF4	Activating transcription factor 4. (346 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	KL	Klotho. (988 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	GCM2	Glial cells missing transcription factor 2. (458 aa)
	FGFR1	Fibroblast growth factor receptor. (809 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (518 aa)
	RXRB	Retinoid X receptor beta. (530 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (504 aa)
	MMP17	Matrix metallopeptidase 17. (589 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
	CYP24A1	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1552 aa)
	GATA3	GATA binding protein 3. (444 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	SLC34A3	Solute carrier family 34 member 3. (621 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (360 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	CASR	Calcium sensing receptor. (1069 aa)
	FGF23	Fibroblast growth factor 23. (193 aa)
	GCM1	Glial cells missing transcription factor 1. (442 aa)
	GNA11	G protein subunit alpha 11. (359 aa)
	PDE4D	Phosphodiesterase. (690 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (516 aa)
	PLD2	Phospholipase. (933 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (563 aa)
	AKAP13	Uncharacterized protein. (1424 aa)
	F6V1J3_MONDO	Uncharacterized protein. (573 aa)
	F6UJ46_MONDO	Uncharacterized protein. (571 aa)
	VDR	Uncharacterized protein. (289 aa)
	GNAI2	G protein subunit alpha i2. (315 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (535 aa)
	SOST	Sclerostin. (214 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
	ENSMODP00000046748	Uncharacterized protein. (501 aa)
	PTHLH	Parathyroid hormone like hormone. (187 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
	ARAF	Uncharacterized protein. (198 aa)
	PLD1	Phospholipase. (1035 aa)
	PTH1R	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (616 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
	ENSMODP00000056348	Uncharacterized protein. (689 aa)
	PDE4C	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (407 aa)
	ENSMODP00000057266	Uncharacterized protein. (496 aa)
	RHOA	Uncharacterized protein. (193 aa)
	ENSMODP00000057649	Uncharacterized protein. (261 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (494 aa)
	ENSMODP00000058393	Arrestin_N domain-containing protein. (120 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (527 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	ENSMODP00000059741	Uncharacterized protein. (70 aa)
	GNAS	Uncharacterized protein. (370 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSMODP00000045924	ENSMODP00000002517	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.464
ADCY1	ADCY3	ENSMODP00000045924	ENSMODP00000019825	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.943
ADCY1	ADCY4	ENSMODP00000045924	ENSMODP00000003686	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.435
ADCY1	ADCY7	ENSMODP00000045924	ENSMODP00000016328	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.495
ADCY1	ADCY8	ENSMODP00000045924	ENSMODP00000001732	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY1	ADCY9	ENSMODP00000045924	ENSMODP00000020470	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.661
ADCY1	ENSMODP00000059741	ENSMODP00000045924	ENSMODP00000059741	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.960
ADCY1	GNAI1	ENSMODP00000045924	ENSMODP00000021359	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.802
ADCY1	GNAI2	ENSMODP00000045924	ENSMODP00000041761	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.802
ADCY1	GNAI3	ENSMODP00000045924	ENSMODP00000002408	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.798
ADCY1	GNAS	ENSMODP00000045924	ENSMODP00000059778	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.960
ADCY1	PDE4A	ENSMODP00000045924	ENSMODP00000007099	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.737
ADCY1	PDE4B	ENSMODP00000045924	ENSMODP00000001277	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.719
ADCY1	PDE4C	ENSMODP00000045924	ENSMODP00000057149	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.719
ADCY1	PDE4D	ENSMODP00000045924	ENSMODP00000024412	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.719
ADCY1	PRKACA	ENSMODP00000045924	ENSMODP00000048595	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.926
ADCY1	PRKCA	ENSMODP00000045924	ENSMODP00000005108	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.907
ADCY1	PRKCB	ENSMODP00000045924	ENSMODP00000045459	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.907
ADCY2	ADCY1	ENSMODP00000002517	ENSMODP00000045924	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.464
ADCY2	ADCY4	ENSMODP00000002517	ENSMODP00000003686	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.422