STRINGSTRING
NDUFC1 NDUFC1 COX7A2L COX7A2L SDHA SDHA ADIPOR1 ADIPOR1 LEPR LEPR IL6 IL6 NDUFA11 NDUFA11 SOCS3 SOCS3 PIK3R3 PIK3R3 NDUFB7 NDUFB7 ITCH ITCH COX6A1 COX6A1 JUN JUN PRKAA2 PRKAA2 NDUFA3 NDUFA3 UQCR11 UQCR11 CASP3 CASP3 NDUFB6 NDUFB6 COX4I1 COX4I1 PRKAG2 PRKAG2 FOS FOS LOC100030489 LOC100030489 AKT3 AKT3 NDUFA6 NDUFA6 NDUFA13 NDUFA13 PPARA PPARA AKT2 AKT2 NDUFA10 NDUFA10 XBP1 XBP1 TGFB1 TGFB1 ATF4 ATF4 RELA RELA EIF2AK3 EIF2AK3 EIF2S1 EIF2S1 IKBKB IKBKB NDUFA1 NDUFA1 CYP2E1 CYP2E1 CYC1 CYC1 NDUFA2 NDUFA2 CEBPA CEBPA MLXIP MLXIP UQCRFS1 UQCRFS1 ADIPOQ ADIPOQ AKT1 AKT1 IL1B IL1B LOC100015788 LOC100015788 COX6B1 COX6B1 NDUFA4 NDUFA4 INSR INSR CASP8 CASP8 PRKAB1 PRKAB1 PRKAG3 PRKAG3 PRKAG1 PRKAG1 COX5B COX5B NDUFB10 NDUFB10 NDUFAB1 NDUFAB1 PKLR PKLR TRAF2 TRAF2 MAP3K5 MAP3K5 TNFRSF1A TNFRSF1A NDUFA9 NDUFA9 ADIPOR2 ADIPOR2 NDUFB11 NDUFB11 F7B3U4_MONDO F7B3U4_MONDO CXCL8 CXCL8 NDUFA8 NDUFA8 PIK3R1 PIK3R1 NDUFS3 NDUFS3 PRKAA1 PRKAA1 NFKB1 NFKB1 MAPK10 MAPK10 NDUFV3 NDUFV3 NDUFB5 NDUFB5 PIK3CA PIK3CA NDUFV1 NDUFV1 COX1 COX1 COX2 COX2 COX3 COX3 CYTB CYTB H9H824_MONDO H9H824_MONDO H9H9I1_MONDO H9H9I1_MONDO F7BQU1_MONDO F7BQU1_MONDO MAPK9 MAPK9 CDC42 CDC42 F7CI75_MONDO F7CI75_MONDO IL6R IL6R IRS1 IRS1 IRS2 IRS2 F7BFL6_MONDO F7BFL6_MONDO F6U2Q2_MONDO F6U2Q2_MONDO CASP18 CASP18 LOC100026811 LOC100026811 NDUFS5 NDUFS5 UQCRC1 UQCRC1 LOC100026672 LOC100026672 MAP3K11 MAP3K11 LEP LEP NDUFA5 NDUFA5 ENSMODP00000045334 ENSMODP00000045334 LOC654275 LOC654275 SDHC SDHC LOC100030139 LOC100030139 NDUFS2 NDUFS2 NDUFB1 NDUFB1 NDUFV2 NDUFV2 NDUFS1 NDUFS1 LOC100020481 LOC100020481 NDUFB4 NDUFB4 BAX BAX NDUFC2 NDUFC2 NDUFA7 NDUFA7 NDUFB8 NDUFB8 PRKAB2 PRKAB2 ENSMODP00000051940 ENSMODP00000051940 NDUFB9 NDUFB9 PIK3CB PIK3CB NDUFS4 NDUFS4 MLXIPL MLXIPL NDUFS8 NDUFS8 SDHB SDHB NDUFS7 NDUFS7 SDHD SDHD ENSMODP00000057502 ENSMODP00000057502 LOC100012494 LOC100012494 CYCS CYCS ENSMODP00000059492 ENSMODP00000059492 GSK3B GSK3B ENSMODP00000060103 ENSMODP00000060103
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NDUFC1NADH:ubiquinone oxidoreductase subunit C1. (77 aa)
COX7A2LCytochrome c oxidase subunit 7A2 like. (114 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
LEPRUncharacterized protein. (893 aa)
IL6Uncharacterized protein. (220 aa)
NDUFA11Uncharacterized protein. (141 aa)
SOCS3Suppressor of cytokine signaling 3. (235 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
NDUFB7NADH:ubiquinone oxidoreductase subunit B7. (124 aa)
ITCHE3 ubiquitin-protein ligase. (901 aa)
COX6A1Cytochrome c oxidase subunit 6A, mitochondrial. (112 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
PRKAA2Non-specific serine/threonine protein kinase. (551 aa)
NDUFA3NADH:ubiquinone oxidoreductase subunit A3. (80 aa)
UQCR11Uncharacterized protein. (56 aa)
CASP3Caspase-3-like protein 1; Belongs to the peptidase C14A family. (276 aa)
NDUFB6NADH:ubiquinone oxidoreductase subunit B6. (127 aa)
COX4I1Cytochrome c oxidase subunit 4I1. (169 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (580 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
LOC100030489COX6C domain-containing protein. (75 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NDUFA6NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (128 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
NDUFA10NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (363 aa)
XBP1X-box binding protein 1. (204 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
ATF4Activating transcription factor 4. (346 aa)
RELARELA proto-oncogene, NF-kB subunit. (543 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1104 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
NDUFA1NADH:ubiquinone oxidoreductase subunit A1. (64 aa)
CYP2E1Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (493 aa)
CYC1Cytochrome c1. (320 aa)
NDUFA2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (100 aa)
CEBPACCAAT enhancer binding protein alpha. (358 aa)
MLXIPMLX interacting protein. (942 aa)
UQCRFS1Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (274 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (256 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
LOC100015788Uncharacterized protein. (82 aa)
COX6B1Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
NDUFA4NDUFA4 mitochondrial complex associated. (82 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (472 aa)
PRKAB1AMPKBI domain-containing protein. (273 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (471 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (310 aa)
COX5BCytochrome c oxidase subunit 5B. (128 aa)
NDUFB10NADH:ubiquinone oxidoreductase subunit B10. (176 aa)
NDUFAB1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (569 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (633 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1390 aa)
TNFRSF1AUncharacterized protein. (453 aa)
NDUFA9Epimerase domain-containing protein. (377 aa)
ADIPOR2Adiponectin receptor 2. (387 aa)
NDUFB11NADH:ubiquinone oxidoreductase subunit B11. (157 aa)
F7B3U4_MONDOUncharacterized protein. (108 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NDUFA8NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (172 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
NDUFS3Complex1_30kDa domain-containing protein; Belongs to the complex I 30 kDa subunit family. (539 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
NFKB1Nuclear factor kappa B subunit 1. (995 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NDUFV3Uncharacterized protein. (421 aa)
NDUFB5NADH:ubiquinone oxidoreductase subunit B5. (195 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NDUFV1NADH:ubiquinone oxidoreductase core subunit V1. (438 aa)
COX1Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (513 aa)
COX2Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (228 aa)
COX3Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex. (261 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (382 aa)
H9H824_MONDONADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (114 aa)
H9H9I1_MONDOUncharacterized protein. (82 aa)
F7BQU1_MONDOCytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (83 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CDC42Cell division cycle 42. (191 aa)
F7CI75_MONDOUncharacterized protein. (223 aa)
IL6RInterleukin-6 receptor alpha. (467 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
IRS2Insulin receptor substrate 2. (1384 aa)
F7BFL6_MONDOUncharacterized protein. (88 aa)
F6U2Q2_MONDOUncharacterized protein. (116 aa)
CASP18Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
LOC100026811Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
NDUFS5Uncharacterized protein. (171 aa)
UQCRC1Ubiquinol-cytochrome c reductase core protein 1. (511 aa)
LOC100026672Uncharacterized protein. (455 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (859 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
NDUFA5Uncharacterized protein. (133 aa)
ENSMODP00000045334Uncharacterized protein. (74 aa)
LOC654275Caspase-3-like protein 2; Belongs to the peptidase C14A family. (276 aa)
SDHCSuccinate dehydrogenase complex subunit C. (217 aa)
LOC100030139Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (111 aa)
NDUFS2NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (480 aa)
NDUFB1Uncharacterized protein. (58 aa)
NDUFV2NADH:ubiquinone oxidoreductase core subunit V2. (279 aa)
NDUFS1NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (726 aa)
LOC100020481Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (78 aa)
NDUFB4Uncharacterized protein. (127 aa)
BAXUncharacterized protein. (296 aa)
NDUFC2NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (118 aa)
NDUFA7Uncharacterized protein. (186 aa)
NDUFB8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
PRKAB2AMPKBI domain-containing protein. (106 aa)
ENSMODP00000051940Uncharacterized protein. (70 aa)
NDUFB9Uncharacterized protein; Belongs to the complex I LYR family. (249 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
NDUFS4Uncharacterized protein. (180 aa)
MLXIPLUncharacterized protein. (260 aa)
NDUFS84Fe-4S ferredoxin-type domain-containing protein. (64 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (292 aa)
NDUFS7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (215 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (173 aa)
ENSMODP00000057502Uncharacterized protein. (201 aa)
LOC100012494Cytochrome c oxidase subunit 6A, mitochondrial. (152 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSMODP00000059492Uncharacterized protein. (77 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
ENSMODP00000060103Uncharacterized protein. (92 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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