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PLCB2 PLCB2 PLCG1 PLCG1 CREB3L3 CREB3L3 ADCY8 ADCY8 SOCS3 SOCS3 GNAI3 GNAI3 ADCY2 ADCY2 PIK3R3 PIK3R3 IGF1 IGF1 SHC4 SHC4 ADCY10 ADCY10 ADCY4 ADCY4 PRKCA PRKCA PLCB1 PLCB1 ITPR1 ITPR1 FOS FOS RAF1 RAF1 MAP2K6 MAP2K6 AKT3 AKT3 CREB3 CREB3 GRB2 GRB2 AKT2 AKT2 SST SST SOS1 SOS1 ATF4 ATF4 ATF2 ATF2 IGFBP3 IGFBP3 MAP2K1 MAP2K1 GH1 GH1 STAT1 STAT1 SOS2 SOS2 SSTR1 SSTR1 GNAQ GNAQ ADCY7 ADCY7 SHC3 SHC3 MAPK13 MAPK13 AKT1 AKT1 CREB3L2 CREB3L2 LOC100011470 LOC100011470 LOC100012174 LOC100012174 ATF6B ATF6B PLCG2 PLCG2 CREB5 CREB5 JAK2 JAK2 MAPK3 MAPK3 ADCY3 ADCY3 IGFALS IGFALS ADCY9 ADCY9 CREBBP CREBBP ITPR2 ITPR2 SSTR5 SSTR5 GNAI1 GNAI1 SHC1 SHC1 CREB3L4 CREB3L4 CRKL CRKL MAPK1 MAPK1 F7FNN8_MONDO F7FNN8_MONDO GNA11 GNA11 MAP3K1 MAP3K1 PIK3R1 PIK3R1 GHR GHR MAPK10 MAPK10 GHRHR GHRHR PIK3CA PIK3CA GHSR GHSR MAPK9 MAPK9 SSTR2 SSTR2 IRS1 IRS1 CACNA1S CACNA1S IRS2 IRS2 KRAS-2 KRAS-2 EP300 EP300 GNAI2 GNAI2 MAP2K3 MAP2K3 GHRH GHRH CREB3L1 CREB3L1 PRKCB PRKCB ADCY1 ADCY1 MAPK14 MAPK14 NRAS NRAS PLCB4 PLCB4 PRKACA PRKACA CACNA1C CACNA1C STAT3 STAT3 PTK2 PTK2 JUNB JUNB PIK3CB PIK3CB MAPK12 MAPK12 ITPR3 ITPR3 SIRT6 SIRT6 GHRL GHRL MTOR MTOR SOCS2 SOCS2 CREB1 CREB1 GSK3B GSK3B ENSMODP00000059741 ENSMODP00000059741 GNAS GNAS HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (508 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
SOCS3Suppressor of cytokine signaling 3. (235 aa)
GNAI3G protein subunit alpha i3. (399 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
IGF1Insulin like growth factor 1. (225 aa)
SHC4SHC adaptor protein 4. (678 aa)
ADCY10Adenylate cyclase 10. (1590 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CREB3BZIP domain-containing protein. (370 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
SSTSomatostatin. (116 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
ATF4Activating transcription factor 4. (346 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
IGFBP3Insulin like growth factor binding protein 3. (283 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. (215 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
GNAQG protein subunit alpha q. (359 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
SHC3SHC adaptor protein 3. (602 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (518 aa)
LOC100011470Signal transducer and activator of transcription. (839 aa)
LOC100012174Signal transducer and activator of transcription. (782 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (504 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (689 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
CREBBPCREB binding protein. (2456 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (347 aa)
GNAI1G protein subunit alpha i1. (354 aa)
SHC1SHC adaptor protein 1. (577 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (360 aa)
CRKLUncharacterized protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
GNA11G protein subunit alpha 11. (359 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1491 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
GHRGrowth hormone receptor. (630 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
GHRHRUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (700 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
IRS2Insulin receptor substrate 2. (1384 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
EP300E1A binding protein p300. (2454 aa)
GNAI2G protein subunit alpha i2. (315 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (239 aa)
GHRHGLUCAGON domain-containing protein. (171 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (535 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NRASGTPase NRas. (195 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2123 aa)
STAT3Signal transducer and activator of transcription. (805 aa)
PTK2Uncharacterized protein. (161 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (357 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
SIRT6Uncharacterized protein. (547 aa)
GHRLUncharacterized protein. (132 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
SOCS2Suppressor of cytokine signaling 2. (234 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
ENSMODP00000059741Uncharacterized protein. (70 aa)
GNASUncharacterized protein. (370 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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