STRINGSTRING
NPY NPY GNG12 GNG12 CREB3L3 CREB3L3 SLC6A3 SLC6A3 GNB5 GNB5 GNAI3 GNAI3 F7E0E8_MONDO F7E0E8_MONDO SHC4 SHC4 CALM1 CALM1 ADORA2A ADORA2A HDAC10 HDAC10 GNG10 GNG10 GRIN3B GRIN3B RAF1 RAF1 PKIA PKIA GNB1 GNB1 GRIN2C GRIN2C CREB3 CREB3 GRB2 GRB2 GNG3 GNG3 LOC100017398 LOC100017398 SLC29A2 SLC29A2 HDAC11 HDAC11 SLC29A3 SLC29A3 SOS1 SOS1 HAT1 HAT1 GNG8 GNG8 DDC DDC ATF4 ATF4 SLC18A2 SLC18A2 CALML4 CALML4 ATF2 ATF2 MAP2K1 MAP2K1 SLC18A1 SLC18A1 HDAC3 HDAC3 SOS2 SOS2 CAMKK2 CAMKK2 PPP1R1B PPP1R1B SHC3 SHC3 CREB3L2 CREB3L2 PDYN PDYN GRIN3A GRIN3A ATF6B ATF6B CREB5 CREB5 PPP1CB PPP1CB MAPK3 MAPK3 GNG13 GNG13 GNAI1 GNAI1 SHC1 SHC1 CREB3L4 CREB3L4 HDAC1 HDAC1 F7BS45_MONDO F7BS45_MONDO MAPK1 MAPK1 HDAC2 HDAC2 GNB3 GNB3 GRIN2B GRIN2B LOC100013589 LOC100013589 SLC29A1 SLC29A1 F7FNN8_MONDO F7FNN8_MONDO CAMKK1 CAMKK1 H2AZ1 H2AZ1 MAOB MAOB MAOA MAOA GNB4 GNB4 FOSB FOSB F7D7P9_MONDO F7D7P9_MONDO F7BPK5_MONDO F7BPK5_MONDO H2AX H2AX DRD1 DRD1 HDAC5 HDAC5 F6XZA2_MONDO F6XZA2_MONDO LOC100618884 LOC100618884 BRAF BRAF NTRK2 NTRK2 CALML3 CALML3 HDAC8 HDAC8 CRH CRH KRAS-2 KRAS-2 LOC100014048 LOC100014048 GNG7 GNG7 GNG4 GNG4 ENSMODP00000041447 ENSMODP00000041447 GNAI2 GNAI2 LOC100011600 LOC100011600 GRIN1 GRIN1 CREB3L1 CREB3L1 ENSMODP00000044660 ENSMODP00000044660 LOC100013669 LOC100013669 LOC100011383 LOC100011383 BDNF BDNF LOC100012131 LOC100012131 PPP1CC PPP1CC H3F3A H3F3A GNGT2 GNGT2 NRAS NRAS ENSMODP00000048543 ENSMODP00000048543 PRKACA PRKACA ARAF ARAF F7DXR0_MONDO F7DXR0_MONDO H2AZ2 H2AZ2 GNG5 GNG5 LOC100011978 LOC100011978 HDAC6 HDAC6 LOC100010184 LOC100010184 HDAC9 HDAC9 LOC100013915 LOC100013915 GRIN2A GRIN2A GNB2 GNB2 CREB1 CREB1 ENSMODP00000059741 ENSMODP00000059741 GNAS GNAS HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPYNeuropeptide Y. (95 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (508 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (709 aa)
GNB5G protein subunit beta 5. (353 aa)
GNAI3G protein subunit alpha i3. (399 aa)
F7E0E8_MONDOBH4_AAA_HYDROXYL_2 domain-containing protein. (391 aa)
SHC4SHC adaptor protein 4. (678 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
HDAC10Hist_deacetyl domain-containing protein. (306 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1019 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
PKIAcAMP-dependent protein kinase inhibitor alpha. (90 aa)
GNB1G protein subunit beta 1. (340 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1242 aa)
CREB3BZIP domain-containing protein. (370 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC100017398Histone H2A; Belongs to the histone H2A family. (126 aa)
SLC29A2Solute carrier family 29 member 2. (448 aa)
HDAC11Histone deacetylase 11. (329 aa)
SLC29A3Solute carrier family 29 member 3. (472 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
DDCDopa decarboxylase. (515 aa)
ATF4Activating transcription factor 4. (346 aa)
SLC18A2Solute carrier family 18 member A2. (514 aa)
CALML4Calmodulin like 4. (156 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SLC18A1Solute carrier family 18 member A1. (526 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
CAMKK2Protein kinase domain-containing protein. (322 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (207 aa)
SHC3SHC adaptor protein 3. (602 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (518 aa)
PDYNProdynorphin. (258 aa)
GRIN3AUncharacterized protein. (1153 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (504 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNAI1G protein subunit alpha i1. (354 aa)
SHC1SHC adaptor protein 1. (577 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (360 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (450 aa)
F7BS45_MONDOUncharacterized protein. (420 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
GNB3G protein subunit beta 3. (340 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1463 aa)
LOC100013589Histone H2B; Belongs to the histone H2B family. (186 aa)
SLC29A1Uncharacterized protein. (515 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (518 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
MAOBAmine oxidase. (520 aa)
MAOAAmine oxidase. (553 aa)
GNB4G protein subunit beta 4. (340 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (334 aa)
F7D7P9_MONDOUncharacterized protein; Belongs to the calmodulin family. (65 aa)
F7BPK5_MONDOHistone H3; Belongs to the histone H3 family. (139 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (145 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (447 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1103 aa)
F6XZA2_MONDOHistone H2A; Belongs to the histone H2A family. (150 aa)
LOC100618884Histone H2A; Belongs to the histone H2A family. (143 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
NTRK2Tyrosine-protein kinase receptor. (750 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (379 aa)
CRHCorticotropin releasing hormone. (194 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
LOC100014048Histone domain-containing protein. (136 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSMODP00000041447Histone H2B; Belongs to the histone H2B family. (126 aa)
GNAI2G protein subunit alpha i2. (315 aa)
LOC100011600Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (938 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (535 aa)
ENSMODP00000044660Histone H2A; Belongs to the histone H2A family. (133 aa)
LOC100013669Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC100011383Histone H2A; Belongs to the histone H2A family. (130 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (285 aa)
LOC100012131Histone H3; Belongs to the histone H3 family. (136 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
NRASGTPase NRas. (195 aa)
ENSMODP00000048543Histone H2A; Belongs to the histone H2A family. (140 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
ARAFUncharacterized protein. (198 aa)
F7DXR0_MONDOHistone H2A; Belongs to the histone H2A family. (130 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC100011978Histone H2A; Belongs to the histone H2A family. (130 aa)
HDAC6Histone deacetylase 6. (1106 aa)
LOC100010184Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1071 aa)
LOC100013915Histone H2A; Belongs to the histone H2A family. (130 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1365 aa)
GNB2G protein subunit beta 2. (367 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
ENSMODP00000059741Uncharacterized protein. (70 aa)
GNASUncharacterized protein. (370 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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