STRINGSTRING
LOC100018520 LOC100018520 VPS18 VPS18 CYFIP1 CYFIP1 LOC100010741 LOC100010741 BIRC2 BIRC2 CYTH4 CYTH4 TXN2 TXN2 DYNC2H1 DYNC2H1 IL6 IL6 ARPC1A ARPC1A ARPC1B ARPC1B MYLPF MYLPF PIK3C2B PIK3C2B MYC MYC RAB7B RAB7B PKN1 PKN1 GCC2 GCC2 DYNLL1 DYNLL1 JUN JUN CASP3 CASP3 TIRAP TIRAP PAK1 PAK1 ARPC4 ARPC4 PFN1 PFN1 VPS16 VPS16 BRK1 BRK1 MYL5 MYL5 FOS FOS ACBD3 ACBD3 TRADD TRADD RAF1 RAF1 MAP2K6 MAP2K6 AKT3 AKT3 DYNC1LI2 DYNC1LI2 RPS3 RPS3 ARPC5 ARPC5 AKT2 AKT2 RIPK2 RIPK2 EXOC5 EXOC5 CYTH3 CYTH3 RAB7A RAB7A EXOC7 EXOC7 EXOC2 EXOC2 KLC2 KLC2 RIPK1 RIPK1 SNX33 SNX33 RHOJ RHOJ IKBKG IKBKG LOC103100524 LOC103100524 TAB1 TAB1 RELA RELA MAP2K1 MAP2K1 IKBKB IKBKB CHUK CHUK PLEKHM1 PLEKHM1 CTNNB1 CTNNB1 GSDMD GSDMD FYCO1 FYCO1 MYL2 MYL2 RAB9B RAB9B ANXA2 ANXA2 F6U132_MONDO F6U132_MONDO FBXO22 FBXO22 LOC100028958 LOC100028958 VPS33A VPS33A DYNC1H1 DYNC1H1 VPS11 VPS11 HSP90AA1 HSP90AA1 MAPK13 MAPK13 AKT1 AKT1 ARF1 ARF1 IL1B IL1B BAK1 BAK1 EXOC4 EXOC4 MAP2K7 MAP2K7 FLNC FLNC CASP8 CASP8 DYNC1LI1 DYNC1LI1 WASL WASL ARPC2 ARPC2 TCF7L1 TCF7L1 MAPK3 MAPK3 ARHGEF26 ARHGEF26 MYL7 MYL7 CSE1L CSE1L KPNA4 KPNA4 PIK3CG PIK3CG TRAF2 TRAF2 MAPK1 MAPK1 M6PR M6PR TNFRSF1A TNFRSF1A KPNA1 KPNA1 IRAK4 IRAK4 HSP90AB1 HSP90AB1 KLC4 KLC4 CXCL8 CXCL8 SNX18 SNX18 TLR4 TLR4 ARPC5L ARPC5L TRAF6 TRAF6 TLR6 TLR6 LEF1 LEF1 NFKB1 NFKB1 MAPK10 MAPK10 LOC100015800 LOC100015800 PFN2 PFN2 PIK3CA PIK3CA LOC100016601 LOC100016601 ELMO2 ELMO2 MAPK9 MAPK9 CYFIP2 CYFIP2 CD14 CD14 TCF7 TCF7 ARF6 ARF6 CDC42 CDC42 RHOG RHOG F7CI75_MONDO F7CI75_MONDO LOC100021555 LOC100021555 VPS39 VPS39 F7G5T5_MONDO F7G5T5_MONDO LOC100032592 LOC100032592 PIK3C2A PIK3C2A TLR5 TLR5 DYNC1I2 DYNC1I2 TLR2 TLR2 LOC100020439 LOC100020439 PYCARD PYCARD RAB9A RAB9A LY96 LY96 ELMO1 ELMO1 PODXL PODXL CASP18 CASP18 K7E453_MONDO K7E453_MONDO GAPDH GAPDH RAB5A RAB5A LOC100026811 LOC100026811 NCKAP1 NCKAP1 HSP90B1 HSP90B1 MAP2K3 MAP2K3 DYNLT3 DYNLT3 MYL9 MYL9 KLC1 KLC1 DYNLL2 DYNLL2 FLNA FLNA ACTG1 ACTG1 PIK3C3 PIK3C3 LOC654275 LOC654275 MYL10 MYL10 DYNLRB1 DYNLRB1 RRAS RRAS MAP3K7 MAP3K7 KPNA3 KPNA3 MAPK14 MAPK14 ABI1 ABI1 BAX BAX DNM2 DNM2 TLR9 TLR9 LOC103102395 LOC103102395 DYNLRB2 DYNLRB2 ENSMODP00000052083 ENSMODP00000052083 FHOD1 FHOD1 TCF7L2 TCF7L2 PIK3CB PIK3CB WASF3 WASF3 MAPK12 MAPK12 TAB2 TAB2 TNFSF10 TNFSF10 NFKBIA NFKBIA SIRT6 SIRT6 MYL12A MYL12A PFN3 PFN3 RHOA RHOA AHNAK AHNAK CYCS CYCS RALA RALA RAB5C RAB5C MYO6 MYO6 LOC103101367 LOC103101367 TAB3 TAB3 FADD FADD NOD1 NOD1 HRAS HRAS ROCK2 ROCK2 S100A10 S100A10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100018520Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa)
VPS18VPS18 core subunit of CORVET and HOPS complexes. (972 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
LOC100010741CARD domain-containing protein. (585 aa)
BIRC2Uncharacterized protein. (383 aa)
CYTH4Cytohesin 4. (394 aa)
TXN2Thioredoxin domain-containing protein. (180 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4270 aa)
IL6Uncharacterized protein. (220 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (367 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (180 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
PKN1Protein kinase N1. (956 aa)
GCC2GRIP and coiled-coil domain containing 2. (1677 aa)
DYNLL1Dynein light chain. (89 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
CASP3Caspase-3-like protein 1; Belongs to the peptidase C14A family. (276 aa)
TIRAPTIR domain-containing protein. (342 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (833 aa)
BRK1Uncharacterized protein. (106 aa)
MYL5Myosin light chain 5. (170 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
ACBD3Acyl-CoA binding domain containing 3. (543 aa)
TRADDTNFRSF1A associated via death domain. (361 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (493 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (304 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (540 aa)
EXOC5Exocyst complex component 5. (650 aa)
CYTH3Cytohesin 3. (401 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (921 aa)
KLC2TPR_REGION domain-containing protein. (522 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (706 aa)
SNX33Sorting nexin. (565 aa)
RHOJRas homolog family member J. (214 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
LOC103100524Uncharacterized protein. (408 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (652 aa)
RELARELA proto-oncogene, NF-kB subunit. (543 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PLEKHM1Pleckstrin homology and RUN domain containing M1. (1018 aa)
CTNNB1Catenin beta 1. (781 aa)
GSDMDUncharacterized protein. (471 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1457 aa)
MYL2Myosin light chain 2. (166 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
ANXA2Annexin. (339 aa)
F6U132_MONDOActin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (176 aa)
FBXO22F-box protein 22. (396 aa)
LOC100028958Uncharacterized protein. (375 aa)
VPS33AUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4594 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (939 aa)
HSP90AA1HATPase_c domain-containing protein. (731 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ARF1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (179 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
BAK1BCL2 antagonist/killer 1. (204 aa)
EXOC4Exocyst complex component 4. (975 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (546 aa)
FLNCFilamin C. (2653 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (472 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (520 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (330 aa)
TCF7L1Transcription factor 7 like 1. (613 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (877 aa)
MYL7Myosin light chain 7. (175 aa)
CSE1LChromosome segregation 1 like. (971 aa)
KPNA4Importin subunit alpha; Functions in nuclear protein import. (521 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1099 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (633 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (279 aa)
TNFRSF1AUncharacterized protein. (453 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (541 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (458 aa)
HSP90AB1Uncharacterized protein. (362 aa)
KLC4Kinesin light chain 4. (611 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SNX18Sorting nexin 18. (642 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (158 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (803 aa)
LEF1Lymphoid enhancer binding factor 1. (401 aa)
NFKB1Nuclear factor kappa B subunit 1. (995 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC100015800Uncharacterized protein. (440 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100016601Uncharacterized protein. (374 aa)
ELMO2Engulfment and cell motility 2. (742 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CYFIP2Cytoplasmic FMR1 interacting protein 2. (1138 aa)
CD14Uncharacterized protein. (382 aa)
TCF7Transcription factor 7. (442 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
CDC42Cell division cycle 42. (191 aa)
RHOGRas homolog family member G. (191 aa)
F7CI75_MONDOUncharacterized protein. (223 aa)
LOC100021555Dynein light chain. (89 aa)
VPS39VPS39 subunit of HOPS complex. (886 aa)
F7G5T5_MONDOUncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
LOC100032592Uncharacterized protein; Belongs to the peptidase C14A family. (375 aa)
PIK3C2AUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1608 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (861 aa)
DYNC1I2Dynein cytoplasmic 1 intermediate chain 2. (652 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
LOC100020439Uncharacterized protein; Belongs to the actin family. (374 aa)
PYCARDPYD and CARD domain containing. (195 aa)
RAB9ARAB9A, member RAS oncogene family. (278 aa)
LY96ML domain-containing protein. (157 aa)
ELMO1PH domain-containing protein. (144 aa)
PODXLUncharacterized protein. (594 aa)
CASP18Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
K7E453_MONDOUncharacterized protein; Belongs to the peptidase C14A family. (413 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (360 aa)
RAB5ARAB5A, member RAS oncogene family. (224 aa)
LOC100026811Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
NCKAP1NCK associated protein 1. (1115 aa)
HSP90B1Heat shock protein 90 beta family member 1. (835 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (239 aa)
DYNLT3Uncharacterized protein. (71 aa)
MYL9Uncharacterized protein. (172 aa)
KLC1Uncharacterized protein. (637 aa)
DYNLL2Dynein light chain. (174 aa)
FLNAFilamin A. (2558 aa)
ACTG1Uncharacterized protein. (375 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
LOC654275Caspase-3-like protein 2; Belongs to the peptidase C14A family. (276 aa)
MYL10Uncharacterized protein. (159 aa)
DYNLRB1Dynein light chain roadblock; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. (104 aa)
RRASRAS related. (255 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (573 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ABI1Abl interactor 1. (508 aa)
BAXUncharacterized protein. (296 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (881 aa)
TLR9TIR domain-containing protein. (1063 aa)
LOC103102395Uncharacterized protein. (207 aa)
DYNLRB2Dynein light chain roadblock; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. (115 aa)
ENSMODP00000052083Gasdermin domain-containing protein. (261 aa)
FHOD1Formin homology 2 domain containing 1. (1181 aa)
TCF7L2Transcription factor 7 like 2. (579 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
WASF3WASP family member 3. (503 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (696 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (301 aa)
NFKBIAANK_REP_REGION domain-containing protein. (400 aa)
SIRT6Uncharacterized protein. (547 aa)
MYL12AMyosin light chain 12A. (178 aa)
PFN3Profilin; Belongs to the profilin family. (163 aa)
RHOAUncharacterized protein. (193 aa)
AHNAKPDZ domain-containing protein. (124 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RALAUncharacterized protein. (501 aa)
RAB5CUncharacterized protein. (216 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1278 aa)
LOC103101367Uncharacterized protein. (211 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (722 aa)
FADDUncharacterized protein. (193 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (938 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1482 aa)
S100A10EF-hand domain-containing protein; Belongs to the S-100 family. (97 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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