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PLCB2 PLCB2 F7F7P9_MONDO F7F7P9_MONDO TICAM1 TICAM1 IL6 IL6 GNAI3 GNAI3 IL10 IL10 PIK3R3 PIK3R3 C3 C3 CD247 CD247 JUN JUN TGFB2 TGFB2 PLCB1 PLCB1 TGFB3 TGFB3 FOS FOS AKT3 AKT3 AKT2 AKT2 TGFB1 TGFB1 IKBKG IKBKG RELA RELA SMAD2 SMAD2 PPP2R2B PPP2R2B IKBKB IKBKB CHUK CHUK IL12A IL12A CALR CALR TGFBR1 TGFBR1 GNA14 GNA14 GNAQ GNAQ CD3G CD3G CD3D CD3D MAPK13 MAPK13 AKT1 AKT1 IL1B IL1B PPP2CA PPP2CA PPP2R1B PPP2R1B CFLAR CFLAR TGFBR2 TGFBR2 CASP8 CASP8 MAPK3 MAPK3 KNG1 KNG1 C1QC C1QC PPP2R2A PPP2R2A GNAI1 GNAI1 MAPK1 MAPK1 TNFRSF1A TNFRSF1A IRAK4 IRAK4 PPP2CB PPP2CB CCL5 CCL5 GNA11 GNA11 GNA15 GNA15 LOC103093665 LOC103093665 CXCL8 CXCL8 TLR4 TLR4 PPP2R2D PPP2R2D PIK3R1 PIK3R1 TRAF6 TRAF6 TLR6 TLR6 NFKB1 NFKB1 MAPK10 MAPK10 PPP2R1A PPP2R1A IFNGR2 IFNGR2 PIK3CA PIK3CA GNAL GNAL NOS2 NOS2 MAPK9 MAPK9 TLR2 TLR2 LOC100021258 LOC100021258 CASP18 CASP18 GNAI2 GNAI2 ADCY1 ADCY1 CD3E CD3E SERPINE1 SERPINE1 MAPK14 MAPK14 PLCB4 PLCB4 C1QB C1QB C1QA C1QA TLR9 TLR9 IL2 IL2 PIK3CB PIK3CB MAPK12 MAPK12 NFKBIA NFKBIA F7BIP4_MONDO F7BIP4_MONDO IFNGR1 IFNGR1 BDKRB2 BDKRB2 FADD FADD ENSMODP00000059741 ENSMODP00000059741 GNAS GNAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
F7F7P9_MONDOUncharacterized protein. (359 aa)
TICAM1TRIF-NTD domain-containing protein. (713 aa)
IL6Uncharacterized protein. (220 aa)
GNAI3G protein subunit alpha i3. (399 aa)
IL10Interleukin 10. (173 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
C3Complement C3. (1641 aa)
CD247CD247 molecule. (166 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
RELARELA proto-oncogene, NF-kB subunit. (543 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (484 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
CALRCalreticulin. (418 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
GNA14G protein subunit alpha 14. (355 aa)
GNAQG protein subunit alpha q. (359 aa)
CD3GCD3g molecule. (180 aa)
CD3DIg_4 domain-containing protein. (272 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (627 aa)
CFLARUncharacterized protein. (266 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (472 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
KNG1Uncharacterized protein. (618 aa)
C1QCComplement C1q C chain. (245 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (419 aa)
GNAI1G protein subunit alpha i1. (354 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
TNFRSF1AUncharacterized protein. (453 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (458 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CCL5C-C motif chemokine ligand 5. (91 aa)
GNA11G protein subunit alpha 11. (359 aa)
GNA15G protein subunit alpha 15. (374 aa)
LOC103093665C-C motif chemokine. (226 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (417 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (803 aa)
NFKB1Nuclear factor kappa B subunit 1. (995 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (410 aa)
IFNGR2Uncharacterized protein. (344 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNALG protein subunit alpha L. (379 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
LOC100021258Type I interferon 1. (198 aa)
CASP18Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
GNAI2G protein subunit alpha i2. (315 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
CD3EIGc2 domain-containing protein. (252 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (413 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
C1QBC1q domain-containing protein. (288 aa)
C1QAC1q domain-containing protein. (245 aa)
TLR9TIR domain-containing protein. (1063 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (142 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
NFKBIAANK_REP_REGION domain-containing protein. (400 aa)
F7BIP4_MONDOIg-like domain-containing protein. (182 aa)
IFNGR1Fibronectin type-III domain-containing protein. (503 aa)
BDKRB2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (381 aa)
FADDUncharacterized protein. (193 aa)
ENSMODP00000059741Uncharacterized protein. (70 aa)
GNASUncharacterized protein. (370 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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