STRINGSTRING
SRC SRC PLCG1 PLCG1 GNG12 GNG12 TICAM1 TICAM1 JAK1 JAK1 IL6 IL6 MYC MYC RPS27A RPS27A GNB5 GNB5 IKBKE IKBKE PIK3R3 PIK3R3 C3 C3 CALM1 CALM1 E2F1 E2F1 NFATC4 NFATC4 JUN JUN UBA52 UBA52 IFN3 IFN3 LOC100021419 LOC100021419 ITPR1 ITPR1 CASP3 CASP3 TLR3 TLR3 GNG10 GNG10 TYK2 TYK2 FOS FOS TRADD TRADD RAF1 RAF1 MAP2K6 MAP2K6 AKT3 AKT3 GNB1 GNB1 AKT2 AKT2 GNG3 GNG3 PIK3R5 PIK3R5 HIF1A HIF1A IKBKG IKBKG GNG8 GNG8 PPP3CC PPP3CC CALML4 CALML4 PDGFB PDGFB RELA RELA MAP2K1 MAP2K1 IKBKB IKBKB CHUK CHUK CCR4 CCR4 F7BDF0_MONDO F7BDF0_MONDO F7BDC7_MONDO F7BDC7_MONDO RB1 RB1 CTNNB1 CTNNB1 LOC103092123 LOC103092123 E2F3 E2F3 Modo-UT10 Modo-UT10 LOC103094634 LOC103094634 CCR1 CCR1 F6W0U8_MONDO F6W0U8_MONDO PTGS2 PTGS2 STAT1 STAT1 ANGPT2 ANGPT2 E2F2 E2F2 TRAF3 TRAF3 CDKN1A CDKN1A IRF3 IRF3 MAPK13 MAPK13 AKT1 AKT1 BAK1 BAK1 MODO-UE MODO-UE MAP2K7 MAP2K7 BECN1 BECN1 CASP8 CASP8 PLCG2 PLCG2 JAK2 JAK2 TCF7L1 TCF7L1 MAPK3 MAPK3 PIK3CG PIK3CG LOC100021198 LOC100021198 CREBBP CREBBP ITPR2 ITPR2 GNG13 GNG13 TRAF2 TRAF2 MAPK1 MAPK1 TNFRSF1A TNFRSF1A ATG3 ATG3 LOC100012335 LOC100012335 GNB3 GNB3 FGF2 FGF2 VEGFA VEGFA F7FNN8_MONDO F7FNN8_MONDO CXCL8 CXCL8 HCK HCK IL6ST IL6ST PIK3R1 PIK3R1 LEF1 LEF1 NFKB1 NFKB1 PPP3CA PPP3CA MAPK10 MAPK10 GNB4 GNB4 PIK3CA PIK3CA F7D7P9_MONDO F7D7P9_MONDO EIF2AK2 EIF2AK2 MAPK9 MAPK9 TCF7 TCF7 CCR3 CCR3 IRF9 IRF9 CALML3 CALML3 F6VUA1_MONDO F6VUA1_MONDO CD86 CD86 LOC100021467 LOC100021467 LOC100021258 LOC100021258 KRAS-2 KRAS-2 EP300 EP300 GNG7 GNG7 CASP18 CASP18 GNG4 GNG4 LOC100026811 LOC100026811 NFATC3 NFATC3 Modo-UT15 Modo-UT15 ENSMODP00000043772 ENSMODP00000043772 ENSMODP00000045298 ENSMODP00000045298 PPP3CB PPP3CB IFNAR2 IFNAR2 PIK3C3 PIK3C3 LOC100619355 LOC100619355 LOC654275 LOC654275 NFATC1 NFATC1 GNGT2 GNGT2 PREX1 PREX1 MAPK14 MAPK14 IFN7 IFN7 MODO-UK MODO-UK NRAS NRAS ENSMODP00000048581 ENSMODP00000048581 BAX BAX CDK6 CDK6 CCND1 CCND1 NFATC2 NFATC2 GNG5 GNG5 LOC100012382 LOC100012382 STAT3 STAT3 TCF7L2 TCF7L2 ZFP36 ZFP36 PIK3CB PIK3CB MAPK12 MAPK12 MODO-UJ MODO-UJ ITPR3 ITPR3 GABARAPL2 GABARAPL2 MODO-UG MODO-UG NFKBIA NFKBIA IFN4 IFN4 SYK SYK LOC100021368 LOC100021368 LOC100010184 LOC100010184 SIRT6 SIRT6 LOC100030002 LOC100030002 IFNGR1 IFNGR1 RCAN1 RCAN1 LOC100024719 LOC100024719 MODO-UB MODO-UB LYN LYN MTOR MTOR LOC103106351 LOC103106351 CYCS CYCS Modo-UA Modo-UA GNB2 GNB2 LOC107651418 LOC107651418 IFN2 IFN2 CREB1 CREB1 FADD FADD GSK3B GSK3B MHC-I MHC-I HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (550 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
TICAM1TRIF-NTD domain-containing protein. (713 aa)
JAK1Protein kinase domain-containing protein. (199 aa)
IL6Uncharacterized protein. (220 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
GNB5G protein subunit beta 5. (353 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (726 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
C3Complement C3. (1641 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
E2F1E2F transcription factor 1. (443 aa)
NFATC4Nuclear factor of activated T cells 4. (902 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
IFN3Uncharacterized protein. (184 aa)
LOC100021419Type I interferon 5. (184 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
CASP3Caspase-3-like protein 1; Belongs to the peptidase C14A family. (276 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
TYK2Tyrosine-protein kinase. (1193 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
TRADDTNFRSF1A associated via death domain. (361 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNB1G protein subunit beta 1. (340 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (873 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (830 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PPP3CCSerine/threonine-protein phosphatase. (517 aa)
CALML4Calmodulin like 4. (156 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
RELARELA proto-oncogene, NF-kB subunit. (543 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (354 aa)
F7BDF0_MONDOG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
F7BDC7_MONDOG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (349 aa)
RB1RB transcriptional corepressor 1. (937 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC103092123MHC class I antigen. (355 aa)
E2F3E2F transcription factor 3. (457 aa)
Modo-UT10MHC class I antigen. (335 aa)
LOC103094634Ig-like domain-containing protein. (333 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
F6W0U8_MONDOG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (608 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
ANGPT2Angiopoietin 2. (495 aa)
E2F2E2F transcription factor 2. (377 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (409 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAK1BCL2 antagonist/killer 1. (204 aa)
MODO-UEIg-like domain-containing protein; Belongs to the MHC class I family. (355 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (546 aa)
BECN1Uncharacterized protein. (448 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (472 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
TCF7L1Transcription factor 7 like 1. (613 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1099 aa)
LOC100021198Uncharacterized protein. (761 aa)
CREBBPCREB binding protein. (2456 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
GNG13G protein subunit gamma 13. (67 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (633 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
TNFRSF1AUncharacterized protein. (453 aa)
ATG3Autophagy-related protein 3. (324 aa)
LOC100012335C2-set_2 domain-containing protein. (336 aa)
GNB3G protein subunit beta 3. (340 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
HCKTyrosine-protein kinase. (538 aa)
IL6STInterleukin 6 signal transducer. (923 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
LEF1Lymphoid enhancer binding factor 1. (401 aa)
NFKB1Nuclear factor kappa B subunit 1. (995 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
GNB4G protein subunit beta 4. (340 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
F7D7P9_MONDOUncharacterized protein; Belongs to the calmodulin family. (65 aa)
EIF2AK2Uncharacterized protein. (651 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TCF7Transcription factor 7. (442 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (356 aa)
IRF9Interferon regulatory factor 9. (425 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
F6VUA1_MONDOUncharacterized protein. (139 aa)
CD86Uncharacterized protein. (238 aa)
LOC100021467Uncharacterized protein. (183 aa)
LOC100021258Type I interferon 1. (198 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
EP300E1A binding protein p300. (2454 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CASP18Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC100026811Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
NFATC3Nuclear factor of activated T cells 3. (1079 aa)
Modo-UT15Ig-like domain-containing protein. (362 aa)
ENSMODP00000043772MHC_I-like_Ag-recog domain-containing protein. (212 aa)
ENSMODP00000045298MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (250 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
IFNAR2Uncharacterized protein. (511 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
LOC100619355Ubiquitin-like domain-containing protein. (77 aa)
LOC654275Caspase-3-like protein 2; Belongs to the peptidase C14A family. (276 aa)
NFATC1Nuclear factor of activated T cells 1. (950 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1655 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFN7Type I interferon 7. (183 aa)
MODO-UKIg-like domain-containing protein; Belongs to the MHC class I family. (414 aa)
NRASGTPase NRas. (195 aa)
ENSMODP00000048581Ig-like domain-containing protein. (339 aa)
BAXUncharacterized protein. (296 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (390 aa)
CCND1Uncharacterized protein. (67 aa)
NFATC2Nuclear factor of activated T cells 2. (927 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC100012382Uncharacterized protein. (329 aa)
STAT3Signal transducer and activator of transcription. (805 aa)
TCF7L2Transcription factor 7 like 2. (579 aa)
ZFP36Uncharacterized protein. (361 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
MODO-UJIg-like domain-containing protein; Belongs to the MHC class I family. (381 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
GABARAPL2Uncharacterized protein. (289 aa)
MODO-UGIg-like domain-containing protein. (235 aa)
NFKBIAANK_REP_REGION domain-containing protein. (400 aa)
IFN4Type I interferon 4. (183 aa)
SYKTyrosine-protein kinase. (588 aa)
LOC100021368Uncharacterized protein. (183 aa)
LOC100010184Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
SIRT6Uncharacterized protein. (547 aa)
LOC100030002G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
IFNGR1Fibronectin type-III domain-containing protein. (503 aa)
RCAN1Regulator of calcineurin 1. (259 aa)
LOC100024719Ig-like domain-containing protein; Belongs to the MHC class I family. (441 aa)
MODO-UBIg-like domain-containing protein; Belongs to the MHC class I family. (376 aa)
LYNTyrosine-protein kinase. (516 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
LOC103106351MHC class I antigen. (357 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Modo-UAIg-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
GNB2G protein subunit beta 2. (367 aa)
LOC107651418Ig-like domain-containing protein. (232 aa)
IFN2Type I interferon 2. (183 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
FADDUncharacterized protein. (193 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
MHC-IIg-like domain-containing protein; Belongs to the MHC class I family. (376 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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