STRINGSTRING
PAK6 PAK6 PLCG1 PLCG1 RAC2 RAC2 GNG12 GNG12 F7F7P9_MONDO F7F7P9_MONDO SAMHD1 SAMHD1 CUL1 CUL1 GNB5 GNB5 GNAI3 GNAI3 PIK3R3 PIK3R3 AP1G1 AP1G1 CD247 CD247 CALM1 CALM1 TRAF5 TRAF5 NFATC4 NFATC4 RAC3 RAC3 JUN JUN IFN3 IFN3 LOC100021419 LOC100021419 AP1G2 AP1G2 PRKCA PRKCA ITPR1 ITPR1 CASP3 CASP3 PAK5 PAK5 AP1S1 AP1S1 PAK1 PAK1 CFL2 CFL2 GNG10 GNG10 AP1M2 AP1M2 FOS FOS TRADD TRADD RAF1 RAF1 MAP2K6 MAP2K6 FBXW11 FBXW11 AKT3 AKT3 RPS6KB1 RPS6KB1 GNB1 GNB1 ELOC ELOC RPS6KB2 RPS6KB2 AKT2 AKT2 GNG3 GNG3 RIPK1 RIPK1 AP1B1 AP1B1 CCNB2 CCNB2 IKBKG IKBKG GNG8 GNG8 TAB1 TAB1 PPP3CC PPP3CC CALML4 CALML4 RELA RELA LIMK2 LIMK2 MAP2K1 MAP2K1 IKBKB IKBKB CHUK CHUK LOC100026571 LOC100026571 CCNB3 CCNB3 LOC103092123 LOC103092123 Modo-UT10 Modo-UT10 LOC103094634 LOC103094634 F6W0U8_MONDO F6W0U8_MONDO CALR CALR STING1 STING1 GNAQ GNAQ CD3G CD3G CD3D CD3D IRF3 IRF3 WEE2 WEE2 MAPK13 MAPK13 AKT1 AKT1 LIMK1 LIMK1 BAK1 BAK1 TAP1 TAP1 MODO-UE MODO-UE CUL5 CUL5 MAP2K7 MAP2K7 CASP8 CASP8 PLCG2 PLCG2 MAPK3 MAPK3 ELOB ELOB ITPR2 ITPR2 GNG13 GNG13 CDK1 CDK1 GNAI1 GNAI1 TRAF2 TRAF2 CRKL CRKL MAPK1 MAPK1 PDIA3 PDIA3 TNFRSF1A TNFRSF1A GNB3 GNB3 PAK2 PAK2 IRAK4 IRAK4 CGAS CGAS F7FNN8_MONDO F7FNN8_MONDO GNA11 GNA11 BCL2L1 BCL2L1 TLR4 TLR4 PIK3R1 PIK3R1 CCNB1 CCNB1 TRAF6 TRAF6 DDB1 DDB1 NFKB1 NFKB1 PPP3CA PPP3CA MAPK10 MAPK10 AP1S3 AP1S3 RNF7 RNF7 GNB4 GNB4 PIK3CA PIK3CA F7D7P9_MONDO F7D7P9_MONDO MAPK9 MAPK9 CDC25C CDC25C AP1M1 AP1M1 CALML3 CALML3 CD4 CD4 TLR2 TLR2 CUL4A CUL4A LOC100021467 LOC100021467 LOC100021258 LOC100021258 KRAS-2 KRAS-2 GNG7 GNG7 CASP18 CASP18 GNG4 GNG4 LOC103099360 LOC103099360 LOC100026811 LOC100026811 GNAI2 GNAI2 MAP2K3 MAP2K3 NFATC3 NFATC3 Modo-UT15 Modo-UT15 ENSMODP00000043772 ENSMODP00000043772 BAD BAD ENSMODP00000045298 ENSMODP00000045298 PPP3CB PPP3CB PRKCB PRKCB CXCR4 CXCR4 CD3E CD3E LOC654275 LOC654275 NFATC1 NFATC1 GNGT2 GNGT2 MAP3K7 MAP3K7 MAPK14 MAPK14 IFN7 IFN7 MODO-UK MODO-UK NRAS NRAS ENSMODP00000048581 ENSMODP00000048581 BAX BAX AP1S2 AP1S2 ENSMODP00000049121 ENSMODP00000049121 LOC100026215 LOC100026215 NFATC2 NFATC2 BTRC BTRC GNG5 GNG5 WEE1 WEE1 ATR ATR PTK2 PTK2 B2M B2M PIK3CB PIK3CB MAPK12 MAPK12 MODO-UJ MODO-UJ ITPR3 ITPR3 RBX1 RBX1 TAB2 TAB2 MODO-UG MODO-UG NFKBIA NFKBIA CUL4B CUL4B IFN4 IFN4 LOC100021368 LOC100021368 LOC100010184 LOC100010184 F7BIP4_MONDO F7BIP4_MONDO SIRT6 SIRT6 LOC100030002 LOC100030002 DCAF1 DCAF1 PAK4 PAK4 LOC100024719 LOC100024719 MODO-UB MODO-UB MTOR MTOR LOC103106351 LOC103106351 CYCS CYCS Modo-UA Modo-UA GNB2 GNB2 LOC107651418 LOC107651418 CHEK1 CHEK1 IFN2 IFN2 FADD FADD MHC-I MHC-I ATM ATM HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK6P21 (RAC1) activated kinase 6. (592 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
RAC2Rac family small GTPase 2. (281 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
F7F7P9_MONDOUncharacterized protein. (359 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (622 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
GNB5G protein subunit beta 5. (353 aa)
GNAI3G protein subunit alpha i3. (399 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
AP1G1AP-1 complex subunit gamma. (829 aa)
CD247CD247 molecule. (166 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (560 aa)
NFATC4Nuclear factor of activated T cells 4. (902 aa)
RAC3Rac family small GTPase 3. (192 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
IFN3Uncharacterized protein. (184 aa)
LOC100021419Type I interferon 5. (184 aa)
AP1G2AP-1 complex subunit gamma. (785 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
CASP3Caspase-3-like protein 1; Belongs to the peptidase C14A family. (276 aa)
PAK5Non-specific serine/threonine protein kinase. (812 aa)
AP1S1Clat_adaptor_s domain-containing protein. (344 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
CFL2ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (195 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (425 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
TRADDTNFRSF1A associated via death domain. (361 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
GNB1G protein subunit beta 1. (340 aa)
ELOCSkp1_POZ domain-containing protein; Belongs to the SKP1 family. (126 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (476 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (706 aa)
AP1B1AP complex subunit beta. (956 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (652 aa)
PPP3CCSerine/threonine-protein phosphatase. (517 aa)
CALML4Calmodulin like 4. (156 aa)
RELARELA proto-oncogene, NF-kB subunit. (543 aa)
LIMK2LIM domain kinase 2. (684 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
LOC100026571Uncharacterized protein. (584 aa)
CCNB3Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (403 aa)
LOC103092123MHC class I antigen. (355 aa)
Modo-UT10MHC class I antigen. (335 aa)
LOC103094634Ig-like domain-containing protein. (333 aa)
F6W0U8_MONDOG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
CALRCalreticulin. (418 aa)
STING1Transmembrane protein 173. (381 aa)
GNAQG protein subunit alpha q. (359 aa)
CD3GCD3g molecule. (180 aa)
CD3DIg_4 domain-containing protein. (272 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (409 aa)
WEE2Protein kinase domain-containing protein. (705 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LIMK1LIM domain kinase 1. (602 aa)
BAK1BCL2 antagonist/killer 1. (204 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (737 aa)
MODO-UEIg-like domain-containing protein; Belongs to the MHC class I family. (355 aa)
CUL5CULLIN_2 domain-containing protein; Belongs to the cullin family. (396 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (546 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (472 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ELOBUbiquitin-like domain-containing protein. (113 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
GNG13G protein subunit gamma 13. (67 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
GNAI1G protein subunit alpha i1. (354 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (633 aa)
CRKLUncharacterized protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
PDIA3Protein disulfide-isomerase. (506 aa)
TNFRSF1AUncharacterized protein. (453 aa)
GNB3G protein subunit beta 3. (340 aa)
PAK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (458 aa)
CGASCyclic GMP-AMP synthase. (518 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
GNA11G protein subunit alpha 11. (359 aa)
BCL2L1BCL2 like 1. (227 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (414 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
DDB1Damage specific DNA binding protein 1. (1026 aa)
NFKB1Nuclear factor kappa B subunit 1. (995 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
AP1S3Clat_adaptor_s domain-containing protein. (257 aa)
RNF7Ring finger protein 7. (113 aa)
GNB4G protein subunit beta 4. (340 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
F7D7P9_MONDOUncharacterized protein; Belongs to the calmodulin family. (65 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CDC25CRhodanese domain-containing protein. (244 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (432 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
CD4CD4. (461 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
CUL4ACullin 4A; Belongs to the cullin family. (765 aa)
LOC100021467Uncharacterized protein. (183 aa)
LOC100021258Type I interferon 1. (198 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CASP18Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC103099360Uncharacterized protein. (260 aa)
LOC100026811Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
GNAI2G protein subunit alpha i2. (315 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (239 aa)
NFATC3Nuclear factor of activated T cells 3. (1079 aa)
Modo-UT15Ig-like domain-containing protein. (362 aa)
ENSMODP00000043772MHC_I-like_Ag-recog domain-containing protein. (212 aa)
BADUncharacterized protein. (212 aa)
ENSMODP00000045298MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (250 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CD3EIGc2 domain-containing protein. (252 aa)
LOC654275Caspase-3-like protein 2; Belongs to the peptidase C14A family. (276 aa)
NFATC1Nuclear factor of activated T cells 1. (950 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFN7Type I interferon 7. (183 aa)
MODO-UKIg-like domain-containing protein; Belongs to the MHC class I family. (414 aa)
NRASGTPase NRas. (195 aa)
ENSMODP00000048581Ig-like domain-containing protein. (339 aa)
BAXUncharacterized protein. (296 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
ENSMODP00000049121Uncharacterized protein. (567 aa)
LOC100026215Uncharacterized protein. (722 aa)
NFATC2Nuclear factor of activated T cells 2. (927 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
WEE1WEE1 G2 checkpoint kinase. (648 aa)
ATRUncharacterized protein. (159 aa)
PTK2Uncharacterized protein. (161 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (122 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
MODO-UJIg-like domain-containing protein; Belongs to the MHC class I family. (381 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
RBX1Uncharacterized protein. (120 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (696 aa)
MODO-UGIg-like domain-containing protein. (235 aa)
NFKBIAANK_REP_REGION domain-containing protein. (400 aa)
CUL4BCULLIN_2 domain-containing protein; Belongs to the cullin family. (1070 aa)
IFN4Type I interferon 4. (183 aa)
LOC100021368Uncharacterized protein. (183 aa)
LOC100010184Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
F7BIP4_MONDOIg-like domain-containing protein. (182 aa)
SIRT6Uncharacterized protein. (547 aa)
LOC100030002G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1575 aa)
PAK4Non-specific serine/threonine protein kinase. (616 aa)
LOC100024719Ig-like domain-containing protein; Belongs to the MHC class I family. (441 aa)
MODO-UBIg-like domain-containing protein; Belongs to the MHC class I family. (376 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
LOC103106351MHC class I antigen. (357 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Modo-UAIg-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
GNB2G protein subunit beta 2. (367 aa)
LOC107651418Ig-like domain-containing protein. (232 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
IFN2Type I interferon 2. (183 aa)
FADDUncharacterized protein. (193 aa)
MHC-IIg-like domain-containing protein; Belongs to the MHC class I family. (376 aa)
ATMTAN domain-containing protein. (112 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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