STRINGSTRING
APPL1 APPL1 RALB RALB RAC2 RAC2 GADD45A GADD45A MSH2 MSH2 MSH6 MSH6 GADD45G GADD45G MYC MYC PIK3R3 PIK3R3 RAC3 RAC3 JUN JUN AXIN2 AXIN2 TGFB2 TGFB2 CASP3 CASP3 APC2 APC2 TGFB3 TGFB3 FOS FOS RAF1 RAF1 AKT3 AKT3 RPS6KB1 RPS6KB1 GRB2 GRB2 RPS6KB2 RPS6KB2 AKT2 AKT2 TGFB1 TGFB1 SOS1 SOS1 EGFR EGFR SMAD2 SMAD2 MAP2K1 MAP2K1 DCC DCC CTNNB1 CTNNB1 TGFA TGFA SOS2 SOS2 TGFBR1 TGFBR1 APC APC MLH1 MLH1 CDKN1A CDKN1A AKT1 AKT1 BAK1 BAK1 TGFBR2 TGFBR2 TCF7L1 TCF7L1 MAPK3 MAPK3 MAPK1 MAPK1 F7FNN8_MONDO F7FNN8_MONDO EREG EREG AREG AREG PIK3R1 PIK3R1 DDB2 DDB2 MSH3 MSH3 LEF1 LEF1 MAPK10 MAPK10 PIK3CA PIK3CA MAPK9 MAPK9 TCF7 TCF7 BRAF BRAF EGF EGF POLK POLK KRAS-2 KRAS-2 LOC100026811 LOC100026811 BBC3 BBC3 BIRC5 BIRC5 AXIN1 AXIN1 RALGDS RALGDS BAD BAD LOC654275 LOC654275 SMAD3 SMAD3 NRAS NRAS BAX BAX ARAF ARAF CCND1 CCND1 TCF7L2 TCF7L2 ENSMODP00000053344 ENSMODP00000053344 PIK3CB PIK3CB SIRT6 SIRT6 RHOA RHOA MTOR MTOR CYCS CYCS RALA RALA GSK3B GSK3B HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (662 aa)
RALBRAS like proto-oncogene B. (206 aa)
RAC2Rac family small GTPase 2. (281 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (168 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (969 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1584 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
RAC3Rac family small GTPase 3. (192 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
AXIN2Axin 2. (838 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
CASP3Caspase-3-like protein 1; Belongs to the peptidase C14A family. (276 aa)
APC2APC_N_CC domain-containing protein. (1586 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (476 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DCCDCC netrin 1 receptor. (1403 aa)
CTNNB1Catenin beta 1. (781 aa)
TGFATransforming growth factor alpha. (159 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
APCAPC regulator of WNT signaling pathway. (2936 aa)
MLH1MutL homolog 1. (731 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAK1BCL2 antagonist/killer 1. (204 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
TCF7L1Transcription factor 7 like 1. (613 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
EREGEpiregulin. (179 aa)
AREGAmphiregulin. (237 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
DDB2WD_REPEATS_REGION domain-containing protein. (480 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1110 aa)
LEF1Lymphoid enhancer binding factor 1. (401 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TCF7Transcription factor 7. (442 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
EGFEpidermal growth factor. (1143 aa)
POLKDNA polymerase kappa. (859 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
LOC100026811Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
BBC3Uncharacterized protein. (318 aa)
BIRC5Uncharacterized protein. (127 aa)
AXIN1Axin 1. (875 aa)
RALGDSUncharacterized protein. (827 aa)
BADUncharacterized protein. (212 aa)
LOC654275Caspase-3-like protein 2; Belongs to the peptidase C14A family. (276 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
NRASGTPase NRas. (195 aa)
BAXUncharacterized protein. (296 aa)
ARAFUncharacterized protein. (198 aa)
CCND1Uncharacterized protein. (67 aa)
TCF7L2Transcription factor 7 like 2. (579 aa)
ENSMODP00000053344WD_REPEATS_REGION domain-containing protein. (474 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
SIRT6Uncharacterized protein. (547 aa)
RHOAUncharacterized protein. (193 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RALAUncharacterized protein. (501 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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