63 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAK6	P21 (RAC1) activated kinase 6. (592 aa)
	EPAS1	HIF-1a_CTAD domain-containing protein. (336 aa)
	RAP1A	Uncharacterized protein. (177 aa)
	PIK3R3	SH2 domain-containing protein. (276 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	PAK5	Non-specific serine/threonine protein kinase. (812 aa)
	PAK1	Non-specific serine/threonine protein kinase. (545 aa)
	VHL	Uncharacterized protein. (158 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (745 aa)
	ELOC	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (126 aa)
	FH	Fumarate hydratase. (504 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	AKT2	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
	EGLN2	Egl-9 family hypoxia inducible factor 2. (396 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (830 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	EGLN1	Uncharacterized protein. (452 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	TGFA	Transforming growth factor alpha. (159 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1387 aa)
	CREBBP	CREB binding protein. (2456 aa)
	ELOB	Ubiquitin-like domain-containing protein. (113 aa)
	PRCC	Proline rich mitotic checkpoint control factor. (499 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
	CRKL	Uncharacterized protein. (303 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	PAK2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator. (789 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
	F7FNN8_MONDO	Uncharacterized protein. (199 aa)
	ARNT2	Aryl hydrocarbon receptor nuclear translocator 2. (716 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	CDC42	Cell division cycle 42. (191 aa)
	F7CI75_MONDO	Uncharacterized protein. (223 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (563 aa)
	KRAS-2	GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
	EP300	E1A binding protein p300. (2454 aa)
	BAD	Uncharacterized protein. (212 aa)
	NRAS	GTPase NRas. (195 aa)
	ARAF	Uncharacterized protein. (198 aa)
	ETS1	ETS proto-oncogene 1, transcription factor. (487 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
	RBX1	Uncharacterized protein. (120 aa)
	SIRT6	Uncharacterized protein. (547 aa)
	EGLN3	Egl-9 family hypoxia inducible factor 3. (244 aa)
	PAK4	Non-specific serine/threonine protein kinase. (616 aa)
	GAB1	GRB2 associated binding protein 1. (743 aa)
	HRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSMODP00000017125	ENSMODP00000009476	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	0.901
AKT1	AKT3	ENSMODP00000017125	ENSMODP00000008221	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	BAD	ENSMODP00000017125	ENSMODP00000044261	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.950
AKT1	CDC42	ENSMODP00000017125	ENSMODP00000032375	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cell division cycle 42.	0.405
AKT1	CDKN1A	ENSMODP00000017125	ENSMODP00000016922	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.963
AKT1	F7CI75_MONDO	ENSMODP00000017125	ENSMODP00000032833	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.405
AKT1	JUN	ENSMODP00000017125	ENSMODP00000004058	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.932
AKT1	MAPK1	ENSMODP00000017125	ENSMODP00000022098	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.925
AKT1	MAPK3	ENSMODP00000017125	ENSMODP00000019557	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.925
AKT1	PIK3CA	ENSMODP00000017125	ENSMODP00000026633	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.955
AKT1	PIK3CB	ENSMODP00000017125	ENSMODP00000053456	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.952
AKT1	PIK3R1	ENSMODP00000017125	ENSMODP00000024566	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.954
AKT1	PIK3R3	ENSMODP00000017125	ENSMODP00000002600	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	SH2 domain-containing protein.	0.949
AKT1	RAF1	ENSMODP00000017125	ENSMODP00000007826	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Raf-1 proto-oncogene, serine/threonine kinase.	0.928
AKT2	AKT1	ENSMODP00000009476	ENSMODP00000017125	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT2	AKT3	ENSMODP00000009476	ENSMODP00000008221	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT2	BAD	ENSMODP00000009476	ENSMODP00000044261	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.950
AKT2	CDC42	ENSMODP00000009476	ENSMODP00000032375	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	Cell division cycle 42.	0.405
AKT2	CDKN1A	ENSMODP00000009476	ENSMODP00000016922	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.963
AKT2	F7CI75_MONDO	ENSMODP00000009476	ENSMODP00000032833	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.405