STRINGSTRING
RALB RALB RAD51 RAD51 RAC2 RAC2 GADD45A GADD45A JAK1 JAK1 GADD45G GADD45G PIK3R3 PIK3R3 E2F1 E2F1 RAC3 RAC3 TGFB2 TGFB2 TGFB3 TGFB3 RAF1 RAF1 AKT3 AKT3 RPS6KB1 RPS6KB1 RPS6KB2 RPS6KB2 AKT2 AKT2 TGFB1 TGFB1 EGFR EGFR IKBKG IKBKG RELA RELA SMAD2 SMAD2 MAP2K1 MAP2K1 IKBKB IKBKB CHUK CHUK RB1 RB1 E2F3 E2F3 TGFA TGFA STAT1 STAT1 TGFBR1 TGFBR1 E2F2 E2F2 CDKN1A CDKN1A AKT1 AKT1 ARHGEF6 ARHGEF6 BAK1 BAK1 TGFBR2 TGFBR2 MAPK3 MAPK3 MAPK1 MAPK1 VEGFA VEGFA BCL2L1 BCL2L1 PIK3R1 PIK3R1 DDB2 DDB2 NFKB1 NFKB1 MAPK10 MAPK10 PIK3CA PIK3CA RALBP1 RALBP1 PLD2 PLD2 MAPK9 MAPK9 CDC42 CDC42 F7CI75_MONDO F7CI75_MONDO BRCA2 BRCA2 BRAF BRAF EGF EGF POLK POLK KRAS-2 KRAS-2 CDKN2A CDKN2A RALGDS RALGDS BAD BAD SMAD3 SMAD3 BAX BAX CDK6 CDK6 ARAF ARAF CCND1 CCND1 ERBB2 ERBB2 PLD1 PLD1 STAT3 STAT3 ENSMODP00000053344 ENSMODP00000053344 PIK3CB PIK3CB MTOR MTOR RALA RALA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RALBRAS like proto-oncogene B. (206 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
RAC2Rac family small GTPase 2. (281 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (168 aa)
JAK1Protein kinase domain-containing protein. (199 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
E2F1E2F transcription factor 1. (443 aa)
RAC3Rac family small GTPase 3. (192 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (476 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
RELARELA proto-oncogene, NF-kB subunit. (543 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
RB1RB transcriptional corepressor 1. (937 aa)
E2F3E2F transcription factor 3. (457 aa)
TGFATransforming growth factor alpha. (159 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
E2F2E2F transcription factor 2. (377 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (777 aa)
BAK1BCL2 antagonist/killer 1. (204 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
BCL2L1BCL2 like 1. (227 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
DDB2WD_REPEATS_REGION domain-containing protein. (480 aa)
NFKB1Nuclear factor kappa B subunit 1. (995 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RALBP1Rho-GAP domain-containing protein. (241 aa)
PLD2Phospholipase. (933 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CDC42Cell division cycle 42. (191 aa)
F7CI75_MONDOUncharacterized protein. (223 aa)
BRCA2Tower domain-containing protein. (3324 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
EGFEpidermal growth factor. (1143 aa)
POLKDNA polymerase kappa. (859 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
CDKN2ATumor suppressor ARF; Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcr [...] (185 aa)
RALGDSUncharacterized protein. (827 aa)
BADUncharacterized protein. (212 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
BAXUncharacterized protein. (296 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (390 aa)
ARAFUncharacterized protein. (198 aa)
CCND1Uncharacterized protein. (67 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
PLD1Phospholipase. (1035 aa)
STAT3Signal transducer and activator of transcription. (805 aa)
ENSMODP00000053344WD_REPEATS_REGION domain-containing protein. (474 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
RALAUncharacterized protein. (501 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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