STRINGSTRING
GADD45A GADD45A GADD45G GADD45G MYC MYC PIK3R3 PIK3R3 CDH1 CDH1 AXIN2 AXIN2 APC2 APC2 RAF1 RAF1 AKT3 AKT3 GRB2 GRB2 AKT2 AKT2 SOS1 SOS1 EGFR EGFR MAP2K1 MAP2K1 CTNNB1 CTNNB1 SOS2 SOS2 CTNNA1 CTNNA1 APC APC MLH1 MLH1 CDKN1A CDKN1A AKT1 AKT1 BAK1 BAK1 TCF7L1 TCF7L1 MAPK3 MAPK3 CTNNA3 CTNNA3 MAPK1 MAPK1 FOXO3 FOXO3 F7FNN8_MONDO F7FNN8_MONDO PIK3R1 PIK3R1 DDB2 DDB2 LEF1 LEF1 PIK3CA PIK3CA TCF7 TCF7 BRAF BRAF EGF EGF POLK POLK KRAS-2 KRAS-2 AXIN1 AXIN1 BAD BAD ILK ILK NRAS NRAS BAX BAX ARAF ARAF CCND1 CCND1 ERBB2 ERBB2 TCF7L2 TCF7L2 ENSMODP00000053344 ENSMODP00000053344 PIK3CB PIK3CB SIRT6 SIRT6 CTNNA2 CTNNA2 GSK3B GSK3B HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45AGrowth arrest and DNA damage inducible alpha. (168 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (888 aa)
AXIN2Axin 2. (838 aa)
APC2APC_N_CC domain-containing protein. (1586 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CTNNB1Catenin beta 1. (781 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
CTNNA1Uncharacterized protein. (906 aa)
APCAPC regulator of WNT signaling pathway. (2936 aa)
MLH1MutL homolog 1. (731 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAK1BCL2 antagonist/killer 1. (204 aa)
TCF7L1Transcription factor 7 like 1. (613 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
CTNNA3Uncharacterized protein. (454 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
FOXO3Fork-head domain-containing protein. (697 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
DDB2WD_REPEATS_REGION domain-containing protein. (480 aa)
LEF1Lymphoid enhancer binding factor 1. (401 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TCF7Transcription factor 7. (442 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
EGFEpidermal growth factor. (1143 aa)
POLKDNA polymerase kappa. (859 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
AXIN1Axin 1. (875 aa)
BADUncharacterized protein. (212 aa)
ILKIntegrin linked kinase. (486 aa)
NRASGTPase NRas. (195 aa)
BAXUncharacterized protein. (296 aa)
ARAFUncharacterized protein. (198 aa)
CCND1Uncharacterized protein. (67 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
TCF7L2Transcription factor 7 like 2. (579 aa)
ENSMODP00000053344WD_REPEATS_REGION domain-containing protein. (474 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
SIRT6Uncharacterized protein. (547 aa)
CTNNA2Uncharacterized protein. (651 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.