STRINGSTRING
GADD45A GADD45A PDGFD PDGFD GADD45G GADD45G PDGFC PDGFC PIK3R3 PIK3R3 IGF1 IGF1 E2F1 E2F1 CDH1 CDH1 MITF MITF FGF16 FGF16 FGF19 FGF19 FGF4 FGF4 RAF1 RAF1 AKT3 AKT3 MDM2 MDM2 AKT2 AKT2 EGFR EGFR PDGFB PDGFB FGF17 FGF17 MAP2K1 MAP2K1 PDGFRB PDGFRB FGFR1 FGFR1 RB1 RB1 E2F3 E2F3 E2F2 E2F2 CDKN1A CDKN1A AKT1 AKT1 BAK1 BAK1 MAPK3 MAPK3 MET MET HGF HGF MAPK1 MAPK1 FGF23 FGF23 FGF2 FGF2 FGF20 FGF20 F7FNN8_MONDO F7FNN8_MONDO PIK3R1 PIK3R1 DDB2 DDB2 PDGFRA PDGFRA FGF5 FGF5 PIK3CA PIK3CA BRAF BRAF EGF EGF POLK POLK KRAS-2 KRAS-2 FGF3 FGF3 CDKN2A CDKN2A BAD BAD PDGFA PDGFA NRAS NRAS BAX BAX CDK6 CDK6 ARAF ARAF CCND1 CCND1 FGF1 FGF1 FGF6 FGF6 ENSMODP00000053344 ENSMODP00000053344 PIK3CB PIK3CB FGF9 FGF9 SIRT6 SIRT6 FGF10 FGF10 FGF18 FGF18 IGF1R IGF1R FGF7 FGF7 HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45AGrowth arrest and DNA damage inducible alpha. (168 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
IGF1Insulin like growth factor 1. (225 aa)
E2F1E2F transcription factor 1. (443 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (888 aa)
MITFMelanocyte inducing transcription factor. (418 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (484 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet derived growth factor receptor beta. (1061 aa)
FGFR1Fibroblast growth factor receptor. (809 aa)
RB1RB transcriptional corepressor 1. (937 aa)
E2F3E2F transcription factor 3. (457 aa)
E2F2E2F transcription factor 2. (377 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAK1BCL2 antagonist/killer 1. (204 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1387 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
FGF23Fibroblast growth factor 23. (193 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
DDB2WD_REPEATS_REGION domain-containing protein. (480 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
FGF5Uncharacterized protein. (125 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
EGFEpidermal growth factor. (1143 aa)
POLKDNA polymerase kappa. (859 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
CDKN2ATumor suppressor ARF; Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcr [...] (185 aa)
BADUncharacterized protein. (212 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
NRASGTPase NRas. (195 aa)
BAXUncharacterized protein. (296 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (390 aa)
ARAFUncharacterized protein. (198 aa)
CCND1Uncharacterized protein. (67 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
ENSMODP00000053344WD_REPEATS_REGION domain-containing protein. (474 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
SIRT6Uncharacterized protein. (547 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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