68 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GADD45A	Growth arrest and DNA damage inducible alpha. (168 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
	PIK3R3	SH2 domain-containing protein. (276 aa)
	SHC4	SHC adaptor protein 4. (678 aa)
	E2F1	E2F transcription factor 1. (443 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (422 aa)
	GAB2	GRB2 associated binding protein 2. (709 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (484 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	AKT2	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (543 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
	CTBP2	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (468 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	RB1	RB transcriptional corepressor 1. (937 aa)
	E2F3	E2F transcription factor 3. (457 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
	E2F2	E2F transcription factor 2. (377 aa)
	CBL	Cbl proto-oncogene. (837 aa)
	SHC3	SHC adaptor protein 3. (602 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	BAK1	BCL2 antagonist/killer 1. (204 aa)
	LOC100011470	Signal transducer and activator of transcription. (839 aa)
	LOC100012174	Signal transducer and activator of transcription. (782 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	SHC1	SHC adaptor protein 1. (577 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (450 aa)
	CRKL	Uncharacterized protein. (303 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	CDKN1B	P27 protein. (199 aa)
	F7FNN8_MONDO	Uncharacterized protein. (199 aa)
	BCL2L1	BCL2 like 1. (227 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
	DDB2	WD_REPEATS_REGION domain-containing protein. (480 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (995 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (461 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (563 aa)
	POLK	DNA polymerase kappa. (859 aa)
	KRAS-2	GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
	CDKN2A	Tumor suppressor ARF; Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcr [...] (185 aa)
	BAD	Uncharacterized protein. (212 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	SMAD3	Mothers against decapentaplegic homolog. (426 aa)
	NRAS	GTPase NRas. (195 aa)
	BAX	Uncharacterized protein. (296 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (390 aa)
	ARAF	Uncharacterized protein. (198 aa)
	CCND1	Uncharacterized protein. (67 aa)
	ENSMODP00000053344	WD_REPEATS_REGION domain-containing protein. (474 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (400 aa)
	SIRT6	Uncharacterized protein. (547 aa)
	HRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CBL	ENSMODP00000044640	ENSMODP00000016553	Tyrosine-protein kinase.	Cbl proto-oncogene.	0.954
ABL1	CDKN1A	ENSMODP00000044640	ENSMODP00000016922	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1A.	0.453
ABL1	CDKN1B	ENSMODP00000044640	ENSMODP00000022723	Tyrosine-protein kinase.	P27 protein.	0.453
ABL1	CRKL	ENSMODP00000044640	ENSMODP00000021994	Tyrosine-protein kinase.	Uncharacterized protein.	0.959
ABL1	GRB2	ENSMODP00000044640	ENSMODP00000009105	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.966
ABL1	LOC100011470	ENSMODP00000044640	ENSMODP00000018532	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.925
ABL1	LOC100012174	ENSMODP00000044640	ENSMODP00000018563	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.925
ABL1	MAPK1	ENSMODP00000044640	ENSMODP00000022098	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.403
ABL1	MAPK3	ENSMODP00000044640	ENSMODP00000019557	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.403
ABL1	RB1	ENSMODP00000044640	ENSMODP00000013976	Tyrosine-protein kinase.	RB transcriptional corepressor 1.	0.937
ABL1	RUNX1	ENSMODP00000044640	ENSMODP00000026321	Tyrosine-protein kinase.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.416
ABL1	SHC1	ENSMODP00000044640	ENSMODP00000021388	Tyrosine-protein kinase.	SHC adaptor protein 1.	0.929
ABL1	SHC3	ENSMODP00000044640	ENSMODP00000016729	Tyrosine-protein kinase.	SHC adaptor protein 3.	0.929
ABL1	SHC4	ENSMODP00000044640	ENSMODP00000003103	Tyrosine-protein kinase.	SHC adaptor protein 4.	0.924
AKT1	AKT2	ENSMODP00000017125	ENSMODP00000009476	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily.	0.901
AKT1	AKT3	ENSMODP00000017125	ENSMODP00000008221	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	BAD	ENSMODP00000017125	ENSMODP00000044261	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.950
AKT1	BCL2L1	ENSMODP00000017125	ENSMODP00000024313	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 like 1.	0.923
AKT1	CDKN1A	ENSMODP00000017125	ENSMODP00000016922	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.963
AKT1	CDKN1B	ENSMODP00000017125	ENSMODP00000022723	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	P27 protein.	0.961