STRINGSTRING
RET RET MYC MYC PKM PKM PIK3R3 PIK3R3 PDHB PDHB PGAM1 PGAM1 HK3 HK3 RAF1 RAF1 LDHC LDHC LDHA LDHA AKT3 AKT3 AKT2 AKT2 FGFR2 FGFR2 HIF1A HIF1A EGFR EGFR PDK1 PDK1 G6PD G6PD MAP2K1 MAP2K1 PDGFRB PDGFRB HK1 HK1 FGFR1 FGFR1 HKDC1 HKDC1 HK2 HK2 GLS GLS AKT1 AKT1 MAPK3 MAPK3 MET MET IDH1 IDH1 SLC2A2 SLC2A2 SLC2A1 SLC2A1 MAPK1 MAPK1 LDHB LDHB F7FNN8_MONDO F7FNN8_MONDO IDH2 IDH2 PIK3R1 PIK3R1 PDGFRA PDGFRA GLS2 GLS2 SIRT3 SIRT3 PIK3CA PIK3CA SLC1A5 SLC1A5 NTRK3 NTRK3 KIT KIT KRAS-2 KRAS-2 SLC16A3 SLC16A3 TIGAR TIGAR LOC100028279 LOC100028279 SLC7A5 SLC7A5 PDHA1 PDHA1 GCK GCK NRAS NRAS FLT3 FLT3 ERBB2 ERBB2 PIK3CB PIK3CB SIRT6 SIRT6 MTOR MTOR HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (635 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (371 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
HK3Hexokinase 3. (1049 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (318 aa)
LDHAL-lactate dehydrogenase A chain. (332 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (830 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
PDK1Protein-serine/threonine kinase. (427 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (616 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet derived growth factor receptor beta. (1061 aa)
HK1Hexokinase 1. (922 aa)
FGFR1Fibroblast growth factor receptor. (809 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK2Hexokinase 2. (932 aa)
GLSEF-hand_14 domain-containing protein. (248 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1387 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (518 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
LDHBL-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (378 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (455 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
GLS2Glutaminase 2. (579 aa)
SIRT3Deacetylase sirtuin-type domain-containing protein. (470 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SLC1A5Amino acid transporter. (525 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
SLC16A3Solute carrier family 16 member 3. (493 aa)
TIGARUncharacterized protein. (269 aa)
LOC100028279L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
SLC7A5Solute carrier family 7 member 5. (533 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (411 aa)
GCKPhosphotransferase. (532 aa)
NRASGTPase NRas. (195 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
SIRT6Uncharacterized protein. (547 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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