STRINGSTRING
PLCG1 PLCG1 RAC2 RAC2 PDGFD PDGFD PDGFC PDGFC F6V079_MONDO F6V079_MONDO PIK3R3 PIK3R3 CHPT1 CHPT1 SLC5A7 SLC5A7 PIP5K1B PIP5K1B RAC3 RAC3 JUN JUN PLPP3 PLPP3 PRKCA PRKCA SLC44A3 SLC44A3 DGKQ DGKQ FOS FOS RAF1 RAF1 PLPP2 PLPP2 AKT3 AKT3 RPS6KB1 RPS6KB1 SLC22A2 SLC22A2 GRB2 GRB2 PCYT1B PCYT1B RPS6KB2 RPS6KB2 AKT2 AKT2 HIF1A HIF1A SOS1 SOS1 EGFR EGFR PDGFB PDGFB MAP2K1 MAP2K1 PDGFRB PDGFRB WAS WAS SOS2 SOS2 TSC1 TSC1 PLA2G4C PLA2G4C AKT1 AKT1 LOC100015440 LOC100015440 LOC100015397 LOC100015397 DGKE DGKE SLC44A4 SLC44A4 MAPK3 MAPK3 TSC2 TSC2 SLC44A1 SLC44A1 MAPK1 MAPK1 PLA2G4E PLA2G4E PIP5K1A PIP5K1A F7FNN8_MONDO F7FNN8_MONDO PIK3R1 PIK3R1 PDGFRA PDGFRA MAPK10 MAPK10 LOC100015800 LOC100015800 PIK3CA PIK3CA CHKA CHKA DGKG DGKG PLD2 PLD2 MAPK9 MAPK9 WASF2 WASF2 DGKH DGKH EGF EGF KRAS-2 KRAS-2 SLC22A1 SLC22A1 RALGDS RALGDS DGKD DGKD PLPP1 PLPP1 PRKCB PRKCB SLC22A3 SLC22A3 PDGFA PDGFA ENSMODP00000048414 ENSMODP00000048414 NRAS NRAS DGKI DGKI PCYT1A PCYT1A PLD1 PLD1 EIF4EBP1 EIF4EBP1 PIK3CB PIK3CB WASF3 WASF3 LYPLA1 LYPLA1 SIRT6 SIRT6 RHEB RHEB MTOR MTOR SLC44A2 SLC44A2 F7GAG3_MONDO F7GAG3_MONDO HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
RAC2Rac family small GTPase 2. (281 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
F6V079_MONDOacidPPc domain-containing protein. (161 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (421 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (556 aa)
RAC3Rac family small GTPase 3. (192 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
PLPP3acidPPc domain-containing protein. (310 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
SLC44A3Solute carrier family 44 member 3; Belongs to the CTL (choline transporter-like) family. (653 aa)
DGKQDiacylglycerol kinase. (972 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
PLPP2Phospholipid phosphatase 2. (218 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
SLC22A2Solute carrier family 22 member 2. (554 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (369 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (476 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (830 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet derived growth factor receptor beta. (1061 aa)
WASWASP actin nucleation promoting factor. (504 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
TSC1TSC complex subunit 1. (1152 aa)
PLA2G4CPLA2c domain-containing protein. (204 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC100015440Solute carrier family 22 member 5. (590 aa)
LOC100015397Solute carrier family 22 member 4. (553 aa)
DGKEDiacylglycerol kinase. (574 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (717 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
TSC2TSC complex subunit 2. (1830 aa)
SLC44A1Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (655 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
PLA2G4EPhospholipase A2. (868 aa)
PIP5K1APIPK domain-containing protein. (630 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC100015800Uncharacterized protein. (440 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHKACholine kinase alpha. (463 aa)
DGKGDiacylglycerol kinase. (839 aa)
PLD2Phospholipase. (933 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
WASF2WASP family member 2. (497 aa)
DGKHDiacylglycerol kinase. (1247 aa)
EGFEpidermal growth factor. (1143 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
SLC22A1Solute carrier family 22 member 1. (637 aa)
RALGDSUncharacterized protein. (827 aa)
DGKDDiacylglycerol kinase. (987 aa)
PLPP1Phospholipid phosphatase 1. (286 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
SLC22A3Solute carrier family 22 member 3. (566 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ENSMODP00000048414Uncharacterized protein. (578 aa)
NRASGTPase NRas. (195 aa)
DGKIDiacylglycerol kinase. (1117 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (415 aa)
PLD1Phospholipase. (1035 aa)
EIF4EBP1Uncharacterized protein. (273 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
WASF3WASP family member 3. (503 aa)
LYPLA1Lysophospholipase 1. (247 aa)
SIRT6Uncharacterized protein. (547 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (716 aa)
F7GAG3_MONDOPLA2c domain-containing protein. (590 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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