STRINGSTRING
PLCG1 PLCG1 TICAM1 TICAM1 JAK1 JAK1 PIK3R3 PIK3R3 CD247 CD247 PTPN11 PTPN11 JUN JUN ZAP70 ZAP70 TIRAP TIRAP BATF BATF FOS FOS RAF1 RAF1 MAP2K6 MAP2K6 AKT3 AKT3 RPS6KB1 RPS6KB1 RPS6KB2 RPS6KB2 AKT2 AKT2 HIF1A HIF1A EGFR EGFR IKBKG IKBKG PPP3CC PPP3CC RELA RELA MAP2K1 MAP2K1 IKBKB IKBKB CHUK CHUK STAT1 STAT1 NFKBIB NFKBIB CD3G CD3G CD3D CD3D TICAM2 TICAM2 MAPK13 MAPK13 AKT1 AKT1 JAK2 JAK2 ALK ALK MAPK3 MAPK3 PRKCQ PRKCQ LCK LCK MAPK1 MAPK1 PTPN6 PTPN6 NFKBIE NFKBIE F7FNN8_MONDO F7FNN8_MONDO CSNK2A1 CSNK2A1 TLR4 TLR4 PIK3R1 PIK3R1 TRAF6 TRAF6 NFKB1 NFKB1 PPP3CA PPP3CA IFNGR2 IFNGR2 PIK3CA PIK3CA CD28 CD28 CD4 CD4 TLR2 TLR2 EGF EGF KRAS-2 KRAS-2 PDCD1 PDCD1 BATF3 BATF3 MAP2K3 MAP2K3 NFATC3 NFATC3 CSNK2A2 CSNK2A2 PPP3CB PPP3CB CD3E CD3E CD274 CD274 NFATC1 NFATC1 MAPK14 MAPK14 NRAS NRAS RASGRP1 RASGRP1 NFATC2 NFATC2 TLR9 TLR9 CSNK2B CSNK2B EML4 EML4 STAT3 STAT3 PIK3CB PIK3CB MAPK12 MAPK12 NFKBIA NFKBIA F7BIP4_MONDO F7BIP4_MONDO SIRT6 SIRT6 IFNGR1 IFNGR1 MAP3K3 MAP3K3 MTOR MTOR HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
TICAM1TRIF-NTD domain-containing protein. (713 aa)
JAK1Protein kinase domain-containing protein. (199 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
CD247CD247 molecule. (166 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
TIRAPTIR domain-containing protein. (342 aa)
BATFBasic leucine zipper ATF-like transcription factor. (137 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (476 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (830 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
PPP3CCSerine/threonine-protein phosphatase. (517 aa)
RELARELA proto-oncogene, NF-kB subunit. (543 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
NFKBIBNFKB inhibitor beta. (314 aa)
CD3GCD3g molecule. (180 aa)
CD3DIg_4 domain-containing protein. (272 aa)
TICAM2TIR domain-containing protein. (223 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
ALKTyrosine-protein kinase receptor. (548 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (695 aa)
LCKTyrosine-protein kinase. (686 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
NFKBIENFKB inhibitor epsilon. (360 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (448 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
NFKB1Nuclear factor kappa B subunit 1. (995 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IFNGR2Uncharacterized protein. (344 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CD28CD28 molecule. (221 aa)
CD4CD4. (461 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
EGFEpidermal growth factor. (1143 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
PDCD1Ig-like domain-containing protein. (511 aa)
BATF3BZIP domain-containing protein. (132 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (239 aa)
NFATC3Nuclear factor of activated T cells 3. (1079 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (392 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
CD3EIGc2 domain-containing protein. (252 aa)
CD274Uncharacterized protein. (274 aa)
NFATC1Nuclear factor of activated T cells 1. (950 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NRASGTPase NRas. (195 aa)
RASGRP1RAS guanyl releasing protein 1. (861 aa)
NFATC2Nuclear factor of activated T cells 2. (927 aa)
TLR9TIR domain-containing protein. (1063 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
EML4EMAP like 4. (1025 aa)
STAT3Signal transducer and activator of transcription. (805 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
NFKBIAANK_REP_REGION domain-containing protein. (400 aa)
F7BIP4_MONDOIg-like domain-containing protein. (182 aa)
SIRT6Uncharacterized protein. (547 aa)
IFNGR1Fibronectin type-III domain-containing protein. (503 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (667 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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