(50 nodes) Autoimmune thyroid disease network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL10	Interleukin 10. (173 aa)
	IFN3	Uncharacterized protein. (184 aa)
	LOC100021419	Type I interferon 5. (184 aa)
	TSHB	Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (138 aa)
	LOC103092123	MHC class I antigen. (355 aa)
	Modo-UT10	MHC class I antigen. (335 aa)
	LOC103094634	Ig-like domain-containing protein. (333 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (137 aa)
	TPO	Thyroid peroxidase. (863 aa)
	LOC100026858	Ig-like domain-containing protein. (262 aa)
	MODO-UE	Ig-like domain-containing protein; Belongs to the MHC class I family. (355 aa)
	LOC100026112	Ig-like domain-containing protein; Belongs to the MHC class II family. (256 aa)
	LOC100026007	Ig-like domain-containing protein; Belongs to the MHC class II family. (256 aa)
	CD80	Uncharacterized protein. (337 aa)
	CD28	CD28 molecule. (221 aa)
	CD86	Uncharacterized protein. (238 aa)
	LOC100021467	Uncharacterized protein. (183 aa)
	LOC100025909	Ig-like domain-containing protein. (282 aa)
	K7DYV5_MONDO	Ig-like domain-containing protein. (295 aa)
	TG	Thyroglobulin. (2726 aa)
	Modo-UT15	Ig-like domain-containing protein. (362 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (275 aa)
	ENSMODP00000043772	MHC_I-like_Ag-recog domain-containing protein. (212 aa)
	LOC100025932	Ig-like domain-containing protein; Belongs to the MHC class II family. (264 aa)
	PRF1	Perforin 1. (559 aa)
	ENSMODP00000045162	Ig-like domain-containing protein; Belongs to the MHC class II family. (276 aa)
	ENSMODP00000045298	MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (250 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (287 aa)
	ENSMODP00000047908	Ig-like domain-containing protein; Belongs to the MHC class II family. (267 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (251 aa)
	IFN7	Type I interferon 7. (183 aa)
	MODO-UK	Ig-like domain-containing protein; Belongs to the MHC class I family. (414 aa)
	ENSMODP00000048581	Ig-like domain-containing protein. (339 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (769 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (142 aa)
	MODO-UJ	Ig-like domain-containing protein; Belongs to the MHC class I family. (381 aa)
	LOC100015759	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (259 aa)
	MODO-UG	Ig-like domain-containing protein. (235 aa)
	IFN4	Type I interferon 4. (183 aa)
	LOC100021368	Uncharacterized protein. (183 aa)
	F7BIP4_MONDO	Ig-like domain-containing protein. (182 aa)
	CGA	Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (146 aa)
	LOC100024719	Ig-like domain-containing protein; Belongs to the MHC class I family. (441 aa)
	MODO-UB	Ig-like domain-containing protein; Belongs to the MHC class I family. (376 aa)
	LOC103106351	MHC class I antigen. (357 aa)
	LOC100026891	Ig-like domain-containing protein. (270 aa)
	Modo-UA	Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
	LOC107651418	Ig-like domain-containing protein. (232 aa)
	IFN2	Type I interferon 2. (183 aa)
	MHC-I	Ig-like domain-containing protein; Belongs to the MHC class I family. (376 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD28	CD40LG	ENSMODP00000035757	ENSMODP00000048298	CD28 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.704
CD28	CD80	ENSMODP00000035757	ENSMODP00000022694	CD28 molecule.	Uncharacterized protein.	0.900
CD28	CD86	ENSMODP00000035757	ENSMODP00000036920	CD28 molecule.	Uncharacterized protein.	0.985
CD28	CTLA4	ENSMODP00000035757	ENSMODP00000043678	CD28 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.707
CD40LG	CD28	ENSMODP00000048298	ENSMODP00000035757	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD28 molecule.	0.704
CD40LG	CD86	ENSMODP00000048298	ENSMODP00000036920	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Uncharacterized protein.	0.744
CD40LG	CTLA4	ENSMODP00000048298	ENSMODP00000043678	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Cytotoxic T-lymphocyte associated protein 4.	0.632
CD40LG	IL10	ENSMODP00000048298	ENSMODP00000002554	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin 10.	0.660
CD40LG	IL2	ENSMODP00000048298	ENSMODP00000052096	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.633
CD40LG	IL5	ENSMODP00000048298	ENSMODP00000017451	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.406
CD80	CD28	ENSMODP00000022694	ENSMODP00000035757	Uncharacterized protein.	CD28 molecule.	0.900
CD80	CD86	ENSMODP00000022694	ENSMODP00000036920	Uncharacterized protein.	Uncharacterized protein.	0.900
CD80	CTLA4	ENSMODP00000022694	ENSMODP00000043678	Uncharacterized protein.	Cytotoxic T-lymphocyte associated protein 4.	0.900
CD86	CD28	ENSMODP00000036920	ENSMODP00000035757	Uncharacterized protein.	CD28 molecule.	0.985
CD86	CD40LG	ENSMODP00000036920	ENSMODP00000048298	Uncharacterized protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.744
CD86	CD80	ENSMODP00000036920	ENSMODP00000022694	Uncharacterized protein.	Uncharacterized protein.	0.900
CD86	CTLA4	ENSMODP00000036920	ENSMODP00000043678	Uncharacterized protein.	Cytotoxic T-lymphocyte associated protein 4.	0.998
CD86	IL10	ENSMODP00000036920	ENSMODP00000002554	Uncharacterized protein.	Interleukin 10.	0.745
CD86	IL2	ENSMODP00000036920	ENSMODP00000052096	Uncharacterized protein.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.555
CD86	IL5	ENSMODP00000036920	ENSMODP00000017451	Uncharacterized protein.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.404