(79 nodes) Rheumatoid arthritis network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MMP1	Matrix metallopeptidase 1. (469 aa)
	MMP3	Matrix metallopeptidase 3. (478 aa)
	LOC100024773	Uncharacterized protein. (227 aa)
	IL6	Uncharacterized protein. (220 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
	TEK	TEK receptor tyrosine kinase. (1124 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (286 aa)
	TNFRSF11A	TNFR-Cys domain-containing protein. (670 aa)
	ANGPT1	Angiopoietin 1. (498 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	ATP6V0D1	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
	ACP5	Tartrate-resistant acid phosphatase type 5. (333 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	PTH	Uncharacterized protein. (137 aa)
	ATP6AP1	Uncharacterized protein. (491 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (508 aa)
	ATP6V1D	Uncharacterized protein. (229 aa)
	CXCL12	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (89 aa)
	ATP6V1B1	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (526 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (854 aa)
	ATP6V1G3	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (824 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
	LOC100026858	Ig-like domain-containing protein. (262 aa)
	LOC100026112	Ig-like domain-containing protein; Belongs to the MHC class II family. (256 aa)
	LOC100026007	Ig-like domain-containing protein; Belongs to the MHC class II family. (256 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	LTB	Lymphotoxin beta; Belongs to the tumor necrosis factor family. (251 aa)
	ATP6V1A	ATPase H+ transporting V1 subunit A. (617 aa)
	CD80	Uncharacterized protein. (337 aa)
	ATP6V1E1	Uncharacterized protein. (226 aa)
	IL17A	Interleukin 17A. (153 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
	CCL5	C-C motif chemokine ligand 5. (91 aa)
	LOC103093665	C-C motif chemokine. (226 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	ATP6V1G1	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	LOC100020922	Uncharacterized protein; Belongs to the peptidase C1 family. (344 aa)
	LOC100017469	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1570 aa)
	CSF1	Uncharacterized protein. (340 aa)
	LOC100022215	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (378 aa)
	LOC100018100	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (156 aa)
	CD28	CD28 molecule. (221 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
	CD86	Uncharacterized protein. (238 aa)
	LOC100025909	Ig-like domain-containing protein. (282 aa)
	TNFSF13	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (249 aa)
	K7DYV5_MONDO	Ig-like domain-containing protein. (295 aa)
	CCL20	C-C motif chemokine. (102 aa)
	LOC103094341	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (114 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (183 aa)
	LOC100012857	Uncharacterized protein; Belongs to the peptidase C1 family. (335 aa)
	ATP6V1C1	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (431 aa)
	ITGB2	Integrin beta. (792 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (275 aa)
	LOC100025932	Ig-like domain-containing protein; Belongs to the MHC class II family. (264 aa)
	LOC100013113	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	ENSMODP00000045162	Ig-like domain-containing protein; Belongs to the MHC class II family. (276 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (287 aa)
	ATP6V0B	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family. (204 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (152 aa)
	ENSMODP00000047908	Ig-like domain-containing protein; Belongs to the MHC class II family. (267 aa)
	LOC100012978	Uncharacterized protein; Belongs to the peptidase C1 family. (346 aa)
	ATP6V1F	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	LOC103102395	Uncharacterized protein. (207 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
	CTSK	Cathepsin K; Belongs to the peptidase C1 family. (332 aa)
	ATP6V0E1	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	F7BIP4_MONDO	Ig-like domain-containing protein. (182 aa)
	ITGAL	Integrin subunit alpha L; Belongs to the integrin alpha chain family. (1126 aa)
	ATP6V0E2	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	ATP6V1H	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (501 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (559 aa)
	LOC103101367	Uncharacterized protein. (211 aa)
	LOC100026891	Ig-like domain-containing protein. (270 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP5	FOS	ENSMODP00000008319	ENSMODP00000007329	Tartrate-resistant acid phosphatase type 5.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.451
ACP5	PTH	ENSMODP00000008319	ENSMODP00000010873	Tartrate-resistant acid phosphatase type 5.	Uncharacterized protein.	0.406
ACP5	TNFSF11	ENSMODP00000008319	ENSMODP00000018584	Tartrate-resistant acid phosphatase type 5.	Tumor necrosis factor ligand superfamily member.	0.648
ANGPT1	FLT1	ENSMODP00000006514	ENSMODP00000011380	Angiopoietin 1.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.896
ANGPT1	LOC100017469	ENSMODP00000006514	ENSMODP00000026063	Angiopoietin 1.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.794
ANGPT1	TEK	ENSMODP00000006514	ENSMODP00000005260	Angiopoietin 1.	TEK receptor tyrosine kinase.	0.993
ATP6AP1	ATP6V0A1	ENSMODP00000011047	ENSMODP00000051930	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.986
ATP6AP1	ATP6V0A2	ENSMODP00000011047	ENSMODP00000015702	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.970
ATP6AP1	ATP6V0A4	ENSMODP00000011047	ENSMODP00000017261	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.972
ATP6AP1	ATP6V0B	ENSMODP00000011047	ENSMODP00000046406	Uncharacterized protein.	ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family.	0.994
ATP6AP1	ATP6V0C	ENSMODP00000011047	ENSMODP00000046831	Uncharacterized protein.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.980
ATP6AP1	ATP6V0D1	ENSMODP00000011047	ENSMODP00000007321	Uncharacterized protein.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.980
ATP6AP1	ATP6V0E1	ENSMODP00000011047	ENSMODP00000054895	Uncharacterized protein.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.871
ATP6AP1	ATP6V0E2	ENSMODP00000011047	ENSMODP00000056185	Uncharacterized protein.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.871
ATP6AP1	ATP6V1A	ENSMODP00000011047	ENSMODP00000022649	Uncharacterized protein.	ATPase H+ transporting V1 subunit A.	0.942
ATP6AP1	ATP6V1B1	ENSMODP00000011047	ENSMODP00000014070	Uncharacterized protein.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.933
ATP6AP1	ATP6V1B2	ENSMODP00000011047	ENSMODP00000012295	Uncharacterized protein.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.933
ATP6AP1	ATP6V1C1	ENSMODP00000011047	ENSMODP00000043064	Uncharacterized protein.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.894
ATP6AP1	ATP6V1D	ENSMODP00000011047	ENSMODP00000012388	Uncharacterized protein.	Uncharacterized protein.	0.899
ATP6AP1	ATP6V1E1	ENSMODP00000011047	ENSMODP00000023008	Uncharacterized protein.	Uncharacterized protein.	0.836