(28 nodes) Primary immunodeficiency network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZAP70	Tyrosine-protein kinase. (619 aa)
	BLNK	B cell linker. (466 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (301 aa)
	CIITA	Class II major histocompatibility complex transactivator. (1121 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (547 aa)
	CD8A	Ig-like domain-containing protein. (340 aa)
	CD8B	Ig-like domain-containing protein. (215 aa)
	RFXAP	RFXA_RFXANK_bdg domain-containing protein. (405 aa)
	LOC100026571	Uncharacterized protein. (584 aa)
	BTK	Tyrosine-protein kinase. (655 aa)
	CD3D	Ig_4 domain-containing protein. (272 aa)
	TAP1	Transporter 1, ATP binding cassette subfamily B member. (737 aa)
	DCLRE1C	DNA cross-link repair 1C. (684 aa)
	LCK	Tyrosine-protein kinase. (686 aa)
	AICDA	Activation induced cytidine deaminase. (195 aa)
	RFX5	Regulatory factor X5. (604 aa)
	IL7R	Fibronectin type-III domain-containing protein. (456 aa)
	RAG2	Recombination activating 2. (527 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1047 aa)
	CD4	CD4. (461 aa)
	K7DYV5_MONDO	Ig-like domain-containing protein. (295 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (303 aa)
	RFXANK	Regulatory factor X associated ankyrin containing protein. (311 aa)
	CD3E	IGc2 domain-containing protein. (252 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (251 aa)
	ORAI1	Uncharacterized protein. (314 aa)
	ENSMODP00000049121	Uncharacterized protein. (567 aa)
	LOC100026215	Uncharacterized protein. (722 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AICDA	CD4	ENSMODP00000022451	ENSMODP00000035778	Activation induced cytidine deaminase.	CD4.	0.681
AICDA	CD40LG	ENSMODP00000022451	ENSMODP00000048298	Activation induced cytidine deaminase.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.682
AICDA	RAG1	ENSMODP00000022451	ENSMODP00000034258	Activation induced cytidine deaminase.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.451
AICDA	UNG	ENSMODP00000022451	ENSMODP00000041231	Activation induced cytidine deaminase.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.	0.657
BLNK	BTK	ENSMODP00000005960	ENSMODP00000014600	B cell linker.	Tyrosine-protein kinase.	0.989
BLNK	ZAP70	ENSMODP00000005960	ENSMODP00000004262	B cell linker.	Tyrosine-protein kinase.	0.776
BTK	BLNK	ENSMODP00000014600	ENSMODP00000005960	Tyrosine-protein kinase.	B cell linker.	0.989
BTK	CD3D	ENSMODP00000014600	ENSMODP00000016898	Tyrosine-protein kinase.	Ig_4 domain-containing protein.	0.430
BTK	CD3E	ENSMODP00000014600	ENSMODP00000046017	Tyrosine-protein kinase.	IGc2 domain-containing protein.	0.530
BTK	CD4	ENSMODP00000014600	ENSMODP00000035778	Tyrosine-protein kinase.	CD4.	0.601
BTK	IKBKG	ENSMODP00000014600	ENSMODP00000011449	Tyrosine-protein kinase.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.919
BTK	IL7R	ENSMODP00000014600	ENSMODP00000025476	Tyrosine-protein kinase.	Fibronectin type-III domain-containing protein.	0.457
BTK	LCK	ENSMODP00000014600	ENSMODP00000021795	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.406
BTK	ZAP70	ENSMODP00000014600	ENSMODP00000004262	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.568
CD3D	BTK	ENSMODP00000016898	ENSMODP00000014600	Ig_4 domain-containing protein.	Tyrosine-protein kinase.	0.430
CD3D	CD3E	ENSMODP00000016898	ENSMODP00000046017	Ig_4 domain-containing protein.	IGc2 domain-containing protein.	0.999
CD3D	CD4	ENSMODP00000016898	ENSMODP00000035778	Ig_4 domain-containing protein.	CD4.	0.620
CD3D	CD40LG	ENSMODP00000016898	ENSMODP00000048298	Ig_4 domain-containing protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.452
CD3D	CD8A	ENSMODP00000016898	ENSMODP00000011886	Ig_4 domain-containing protein.	Ig-like domain-containing protein.	0.911
CD3D	CD8B	ENSMODP00000016898	ENSMODP00000011916	Ig_4 domain-containing protein.	Ig-like domain-containing protein.	0.851