STRINGSTRING
era era rnc rnc AGW91263.1 AGW91263.1 AGW91269.1 AGW91269.1 rne rne AGW91399.1 AGW91399.1 AGW91673.1 AGW91673.1 AGW91675.1 AGW91675.1 AGW91912.1 AGW91912.1 obgE obgE rsmH rsmH AGW92388.1 AGW92388.1 AGW91149.1 AGW91149.1 rlmE rlmE rlmD rlmD rlmN rlmN der der rlmB rlmB AGW91067.1 AGW91067.1 AGW91034.1 AGW91034.1 rimP rimP rbfA rbfA AGW91023.1 AGW91023.1 AGW90651.1 AGW90651.1 rlmJ rlmJ AGW89805.1 AGW89805.1 rplT rplT AGW89274.1 AGW89274.1 rph rph rsfS rsfS rlmH rlmH AGW89216.1 AGW89216.1 AGW88894.1 AGW88894.1 rsmA rsmA AGW88726.1 AGW88726.1 AGW92438.1 AGW92438.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
eraGTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (312 aa)
rncRibonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (256 aa)
AGW91263.1K07040: K07040; uncharacterized protein. (199 aa)
AGW91269.1K06179: rluC; 23S rRNA pseudouridine955/2504/2580 synthase [EC:5.4.99.24]. (333 aa)
rneRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1039 aa)
AGW91399.1K06949: rsgA, engC; ribosome biogenesis GTPase [EC:3.6.1.-]. (323 aa)
AGW91673.1K07447: ruvX; putative holliday junction resolvase [EC:3.1.-.-]. (141 aa)
AGW91675.1K06183: rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]. (235 aa)
AGW91912.1K09761: rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]. (250 aa)
obgEGTPase CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (365 aa)
rsmH16S rRNA methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (330 aa)
AGW92388.1K03501: gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]. (235 aa)
AGW91149.1RNA-binding protein. (167 aa)
rlmE23S rRNA methyltransferase; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (221 aa)
rlmD23S rRNA methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (483 aa)
rlmN50S rRNA methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (384 aa)
derGTP-binding protein Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (447 aa)
rlmB23S rRNA (guanosine-2'-O-)-methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (247 aa)
AGW91067.1K03578: hrpA; ATP-dependent helicase HrpA [EC:3.6.4.13]. (1269 aa)
AGW91034.1K06178: rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]. (629 aa)
rimPRibosome maturation protein RimP; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (162 aa)
rbfARibosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (122 aa)
AGW91023.1K06207: typA, bipA; GTP-binding protein. (606 aa)
AGW90651.116S rRNA uridine-516 pseudouridylate synthase; K06182: rluF; 23S rRNA pseudouridine2604 synthase [EC:5.4.99.21]; Belongs to the pseudouridine synthase RsuA family. (656 aa)
rlmJCompetence protein ComJ; Specifically methylates the adenine in position 2030 of 23S rRNA. (285 aa)
AGW89805.1K06180: rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]. (416 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa)
AGW89274.1Stress-induced protein. (311 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (239 aa)
rsfSIojap family protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (253 aa)
rlmH50S rRNA methyltransferase; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (159 aa)
AGW89216.1K02860: rimM; 16S rRNA processing protein RimM. (226 aa)
AGW88894.1Metalloprotease; Contains unknown N-terminal domain/putative metalloprotease C-terminal domain; K07042: ybeY, yqfG; probable rRNA maturation factor. (250 aa)
rsmA16S rRNA methyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (280 aa)
AGW88726.1Methyltransferase. (228 aa)
AGW92438.1K03500: rsmB, sun; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]. (472 aa)
Your Current Organism:
Ralstonia pickettii DTP0602
NCBI taxonomy Id: 1366050
Other names: R. pickettii DTP0602
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