STRINGSTRING
AYL99_01562 AYL99_01562 AYL99_00903 AYL99_00903 AYL99_01311 AYL99_01311 AYL99_01330 AYL99_01330 AYL99_00125 AYL99_00125 AYL99_00590 AYL99_00590 AYL99_02922 AYL99_02922 AYL99_02882 AYL99_02882 FEN1 FEN1 AYL99_02738 AYL99_02738 AYL99_02410 AYL99_02410 AYL99_02216 AYL99_02216 AYL99_01813 AYL99_01813 AYL99_02084 AYL99_02084 AYL99_04655 AYL99_04655 AYL99_04689 AYL99_04689 AYL99_04633 AYL99_04633 AYL99_04457 AYL99_04457 AYL99_03558 AYL99_03558 AYL99_04203 AYL99_04203 AYL99_03692 AYL99_03692 AYL99_05517 AYL99_05517 AYL99_05497 AYL99_05497 AYL99_05778 AYL99_05778 AYL99_03311 AYL99_03311 AYL99_03285 AYL99_03285 AYL99_05796 AYL99_05796 AYL99_05336 AYL99_05336 AYL99_05311 AYL99_05311 AYL99_05170 AYL99_05170 AYL99_05136 AYL99_05136 AYL99_05089 AYL99_05089 AYL99_04889 AYL99_04889 AYL99_06170 AYL99_06170 AYL99_06668 AYL99_06668 AYL99_06271 AYL99_06271 AYL99_06215 AYL99_06215 AYL99_06185 AYL99_06185 AYL99_07085 AYL99_07085 AYL99_07720 AYL99_07720 AYL99_07587 AYL99_07587 AYL99_07410 AYL99_07410 AYL99_08535 AYL99_08535 AYL99_09105 AYL99_09105 AYL99_08009 AYL99_08009 AYL99_07976 AYL99_07976 AYL99_08819 AYL99_08819 AYL99_08809 AYL99_08809 AYL99_08726 AYL99_08726 AYL99_09686 AYL99_09686 AYL99_09629 AYL99_09629 AYL99_09807 AYL99_09807 AYL99_09409 AYL99_09409 AYL99_09276 AYL99_09276 AYL99_10913 AYL99_10913 AYL99_10374 AYL99_10374 AYL99_10921 AYL99_10921 AYL99_11155 AYL99_11155
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AYL99_01562Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (447 aa)
AYL99_00903Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (708 aa)
AYL99_01311Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (404 aa)
AYL99_01330Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (412 aa)
AYL99_00125Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (615 aa)
AYL99_00590Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (345 aa)
AYL99_02922Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (935 aa)
AYL99_02882Protein phosphatase; Belongs to the PP2C family. (462 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (398 aa)
AYL99_02738Plasma membrane ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. (999 aa)
AYL99_02410Phosphoglucomutase; Belongs to the phosphohexose mutase family. (555 aa)
AYL99_02216S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (392 aa)
AYL99_01813PPM-type phosphatase domain-containing protein. (1045 aa)
AYL99_02084Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1596 aa)
AYL99_04655Pyruvate kinase; Belongs to the pyruvate kinase family. (524 aa)
AYL99_04689Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (933 aa)
AYL99_04633Uncharacterized protein. (576 aa)
AYL99_04457Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (507 aa)
AYL99_03558Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1539 aa)
AYL99_04203Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1365 aa)
AYL99_03692Probable acetate kinase. (417 aa)
AYL99_05517Uncharacterized protein. (590 aa)
AYL99_05497Fatty acid synthase subunit alpha; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. (1867 aa)
AYL99_05778Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
AYL99_03311Protein phosphatase. (450 aa)
AYL99_03285Glutathione synthetase. (548 aa)
AYL99_05796Fumarylacetoacetase. (429 aa)
AYL99_05336ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (808 aa)
AYL99_05311Inositol-1-monophosphatase. (316 aa)
AYL99_05170Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (443 aa)
AYL99_05136Plasma membrane ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. (938 aa)
AYL99_05089HpcH_HpaI domain-containing protein. (316 aa)
AYL99_04889Uncharacterized protein. (579 aa)
AYL99_06170Fumarylacetoacetase. (433 aa)
AYL99_06668Acetolactate synthase. (699 aa)
AYL99_06271Magnesium transporter. (457 aa)
AYL99_06215Uncharacterized protein. (582 aa)
AYL99_06185Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (365 aa)
AYL99_070853,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (240 aa)
AYL99_07720Isocitrate lyase. (537 aa)
AYL99_07587Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (357 aa)
AYL99_07410Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
AYL99_08535PPM-type phosphatase domain-containing protein. (603 aa)
AYL99_09105Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1235 aa)
AYL99_08009Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (428 aa)
AYL99_07976Uncharacterized protein. (639 aa)
AYL99_08819Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
AYL99_08809Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1350 aa)
AYL99_08726Magnesium transporter. (487 aa)
AYL99_09686Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. Belongs to the phosphohexose mutase family. (567 aa)
AYL99_09629Uncharacterized protein. (571 aa)
AYL99_09807Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1324 aa)
AYL99_09409Alkaline phosphatase. (611 aa)
AYL99_09276Cyanuric acid amidohydrolase; Responsible for the hydrolysis of cyanuric acid, an intermediate formed during catabolism of s-triazine based compounds in herbicides such as atrazine and polymers such as melamine. Catalyzes the hydrolytic opening of the s-triazine ring of cyanuric acid (2,4,6- trihydroxy-s-triazine) to yield carbon dioxide and carboxybiuret, which spontaneously decarboxylates to biuret; Belongs to the cyclic amide hydrolase (CyAH) family. (358 aa)
AYL99_10913Isocitrate lyase. (564 aa)
AYL99_10374Uncharacterized protein. (600 aa)
AYL99_10921ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (795 aa)
AYL99_11155Mur_ligase_M domain-containing protein. (458 aa)
Your Current Organism:
Fonsecaea erecta
NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a
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