STRINGSTRING
AYL99_06329 AYL99_06329 AYL99_01398 AYL99_01398 AYL99_01318 AYL99_01318 AYL99_01736 AYL99_01736 AYL99_01181 AYL99_01181 AYL99_00313 AYL99_00313 AYL99_00360 AYL99_00360 FEN1 FEN1 AYL99_02602 AYL99_02602 AYL99_02840 AYL99_02840 AYL99_02996 AYL99_02996 AYL99_02102 AYL99_02102 AYL99_01830 AYL99_01830 AYL99_01780 AYL99_01780 AYL99_02018 AYL99_02018 AYL99_01923 AYL99_01923 AYL99_02211 AYL99_02211 AYL99_01927 AYL99_01927 AYL99_04545 AYL99_04545 AYL99_04490 AYL99_04490 AYL99_04044 AYL99_04044 AYL99_04075 AYL99_04075 AYL99_03874 AYL99_03874 AYL99_04172 AYL99_04172 AYL99_05905 AYL99_05905 AYL99_03365 AYL99_03365 AYL99_05754 AYL99_05754 AYL99_05275 AYL99_05275 AYL99_05761 AYL99_05761 AYL99_05701 AYL99_05701 AYL99_05600 AYL99_05600 AYL99_04965 AYL99_04965 AYL99_05354 AYL99_05354 AYL99_04746 AYL99_04746 AYL99_06401 AYL99_06401 AYL99_07421 AYL99_07421 AYL99_07384 AYL99_07384 AYL99_08289 AYL99_08289 AYL99_08169 AYL99_08169 AYL99_08116 AYL99_08116 AYL99_09214 AYL99_09214 AYL99_08005 AYL99_08005 AYL99_08970 AYL99_08970 AYL99_09332 AYL99_09332 AYL99_09515 AYL99_09515 MCM7 MCM7 AYL99_10020 AYL99_10020 AYL99_10524 AYL99_10524 AYL99_10605 AYL99_10605 AYL99_10407 AYL99_10407 AYL99_11234 AYL99_11234 AYL99_11089 AYL99_11089 AYL99_11180 AYL99_11180 AYL99_11718 AYL99_11718 AYL99_11088 AYL99_11088 AYL99_10958 AYL99_10958 AYL99_11749 AYL99_11749 AYL99_11672 AYL99_11672 AYL99_11717 AYL99_11717 AYL99_11873 AYL99_11873 AYL99_11593 AYL99_11593 AYL99_11924 AYL99_11924 AYL99_12021 AYL99_12021 AYL99_12028 AYL99_12028 AYL99_12115 AYL99_12115
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AYL99_06329Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (606 aa)
AYL99_01398Ubiquitin-40S ribosomal protein S27a. (154 aa)
AYL99_01318DNA primase; Belongs to the eukaryotic-type primase small subunit family. (534 aa)
AYL99_01736AAA domain-containing protein. (1107 aa)
AYL99_01181CMGC/CDK/CDK5 protein kinase. (1920 aa)
AYL99_00313DNA ligase. (871 aa)
AYL99_00360Uncharacterized protein. (457 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (398 aa)
AYL99_02602Uncharacterized protein. (559 aa)
AYL99_02840AAA domain-containing protein. (407 aa)
AYL99_02996Polyubiquitin. (229 aa)
AYL99_02102Uncharacterized protein. (528 aa)
AYL99_01830DNA polymerase. (1107 aa)
AYL99_01780Uncharacterized protein. (308 aa)
AYL99_02018DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (640 aa)
AYL99_01923Uncharacterized protein. (231 aa)
AYL99_02211Uncharacterized protein. (131 aa)
AYL99_01927CBFD_NFYB_HMF domain-containing protein. (199 aa)
AYL99_04545Cell division control protein; Belongs to the CDC6/cdc18 family. (605 aa)
AYL99_04490Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (412 aa)
AYL99_04044DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (859 aa)
AYL99_04075DNA helicase; Belongs to the MCM family. (725 aa)
AYL99_03874AAA domain-containing protein. (408 aa)
AYL99_04172DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (262 aa)
AYL99_05905Sld5 domain-containing protein. (236 aa)
AYL99_03365RING-box protein 1A. (124 aa)
AYL99_05754DNA replication ATP-dependent helicase Dna2. (1703 aa)
AYL99_05275DNA polymerase. (1451 aa)
AYL99_05761Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (482 aa)
AYL99_05701UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (321 aa)
AYL99_05600BZIP domain-containing protein. (434 aa)
AYL99_04965DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (246 aa)
AYL99_05354DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (503 aa)
AYL99_04746DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2239 aa)
AYL99_06401Sld5 domain-containing protein. (182 aa)
AYL99_07421DNA helicase; Belongs to the MCM family. (865 aa)
AYL99_07384Zds_C domain-containing protein. (837 aa)
AYL99_08289ANK_REP_REGION domain-containing protein. (1074 aa)
AYL99_08169Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (730 aa)
AYL99_08116Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (763 aa)
AYL99_09214DNA helicase; Belongs to the MCM family. (967 aa)
AYL99_08005Uncharacterized protein. (439 aa)
AYL99_08970Replication factor C subunit 4. (351 aa)
AYL99_09332CBFD_NFYB_HMF domain-containing protein. (361 aa)
AYL99_09515Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (328 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (815 aa)
AYL99_10020DNA helicase; Belongs to the MCM family. (900 aa)
AYL99_10524Replication factor C subunit 1. (1087 aa)
AYL99_10605Uncharacterized protein. (503 aa)
AYL99_10407Replication factor C subunit 5. (355 aa)
AYL99_11234DNA_pol_E_B domain-containing protein. (862 aa)
AYL99_11089Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (512 aa)
AYL99_11180DNA helicase; Belongs to the MCM family. (997 aa)
AYL99_11718Uncharacterized protein. (570 aa)
AYL99_11088Vezatin domain-containing protein. (592 aa)
AYL99_10958Uncharacterized protein. (148 aa)
AYL99_11749DNA_pol_B domain-containing protein. (249 aa)
AYL99_11672RT_RNaseH_2 domain-containing protein. (320 aa)
AYL99_11717C2H2-type domain-containing protein. (699 aa)
AYL99_11873Reverse transcriptase domain-containing protein. (499 aa)
AYL99_11593RT_RNaseH_2 domain-containing protein. (153 aa)
AYL99_11924RT_RNaseH_2 domain-containing protein. (136 aa)
AYL99_12021Uncharacterized protein. (666 aa)
AYL99_12028BZIP domain-containing protein. (129 aa)
AYL99_12115Cyclin N-terminal domain-containing protein. (201 aa)
Your Current Organism:
Fonsecaea erecta
NCBI taxonomy Id: 1367422
Other names: F. erecta, Fonsecaea erecta V. A. Vicente, Najafzadeh, Sun & de Hoog 2013, Fonsecaea sp. RG-2013a
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