(18 nodes) Mixed, incl. Growth hormone receptor signaling pathway, and Regulation of IFNG signaling network (Pelodiscus sinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102460336	SH2 domain-containing protein. (241 aa)
	LOC102450184	Uncharacterized protein. (188 aa)
	JAK3	Tyrosine-protein kinase. (991 aa)
	LEPR	Leptin receptor. (1150 aa)
	JAK1	Tyrosine-protein kinase. (1169 aa)
	IRF1	Interferon regulatory factor. (316 aa)
	STAT1	Signal transducer and activator of transcription 1. (1228 aa)
	IFNGR2	Interferon gamma receptor 2. (366 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (547 aa)
	JAK2	Tyrosine-protein kinase. (1137 aa)
	IFNAR2	Uncharacterized protein. (499 aa)
	K7GA90_PELSI	STAT_int domain-containing protein. (636 aa)
	IRF7	Interferon regulatory factor 7. (477 aa)
	IFNGR1	Interferon gamma receptor 1. (481 aa)
	STAT3	Signal transducer and activator of transcription. (707 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (168 aa)
	SOCS1	Suppressor of cytokine signaling 1. (207 aa)
	GHR	Growth hormone receptor. (615 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GHR	JAK1	ENSPSIP00000020486	ENSPSIP00000010616	Growth hormone receptor.	Tyrosine-protein kinase.	0.699
GHR	JAK2	ENSPSIP00000020486	ENSPSIP00000014597	Growth hormone receptor.	Tyrosine-protein kinase.	0.817
GHR	JAK3	ENSPSIP00000020486	ENSPSIP00000007415	Growth hormone receptor.	Tyrosine-protein kinase.	0.817
GHR	K7GA90_PELSI	ENSPSIP00000020486	ENSPSIP00000017201	Growth hormone receptor.	STAT_int domain-containing protein.	0.624
GHR	LEPR	ENSPSIP00000020486	ENSPSIP00000010143	Growth hormone receptor.	Leptin receptor.	0.486
IFNAR1	IFNAR2	ENSPSIP00000013981	ENSPSIP00000014725	Interferon alpha and beta receptor subunit 1.	Uncharacterized protein.	0.996
IFNAR1	IFNG	ENSPSIP00000013981	ENSPSIP00000018881	Interferon alpha and beta receptor subunit 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.954
IFNAR1	IFNGR1	ENSPSIP00000013981	ENSPSIP00000017584	Interferon alpha and beta receptor subunit 1.	Interferon gamma receptor 1.	0.949
IFNAR1	IFNGR2	ENSPSIP00000013981	ENSPSIP00000013531	Interferon alpha and beta receptor subunit 1.	Interferon gamma receptor 2.	0.943
IFNAR1	IRF7	ENSPSIP00000013981	ENSPSIP00000017297	Interferon alpha and beta receptor subunit 1.	Interferon regulatory factor 7.	0.550
IFNAR1	JAK1	ENSPSIP00000013981	ENSPSIP00000010616	Interferon alpha and beta receptor subunit 1.	Tyrosine-protein kinase.	0.996
IFNAR1	JAK2	ENSPSIP00000013981	ENSPSIP00000014597	Interferon alpha and beta receptor subunit 1.	Tyrosine-protein kinase.	0.963
IFNAR1	JAK3	ENSPSIP00000013981	ENSPSIP00000007415	Interferon alpha and beta receptor subunit 1.	Tyrosine-protein kinase.	0.645
IFNAR1	K7GA90_PELSI	ENSPSIP00000013981	ENSPSIP00000017201	Interferon alpha and beta receptor subunit 1.	STAT_int domain-containing protein.	0.576
IFNAR1	LOC102450184	ENSPSIP00000013981	ENSPSIP00000001022	Interferon alpha and beta receptor subunit 1.	Uncharacterized protein.	0.939
IFNAR1	SOCS1	ENSPSIP00000013981	ENSPSIP00000019315	Interferon alpha and beta receptor subunit 1.	Suppressor of cytokine signaling 1.	0.855
IFNAR1	STAT1	ENSPSIP00000013981	ENSPSIP00000011670	Interferon alpha and beta receptor subunit 1.	Signal transducer and activator of transcription 1.	0.897
IFNAR1	STAT3	ENSPSIP00000013981	ENSPSIP00000018063	Interferon alpha and beta receptor subunit 1.	Signal transducer and activator of transcription.	0.791
IFNAR2	IFNAR1	ENSPSIP00000014725	ENSPSIP00000013981	Uncharacterized protein.	Interferon alpha and beta receptor subunit 1.	0.996
IFNAR2	IFNG	ENSPSIP00000014725	ENSPSIP00000018881	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.952