STRINGSTRING
LOC102456451 LOC102456451 LOC102456698 LOC102456698 FOXO1 FOXO1 TSSK2 TSSK2 FOXO4 FOXO4 CAB39L CAB39L LAMTOR1 LAMTOR1 STK11 STK11 RHEBL1 RHEBL1 RPS6KA2 RPS6KA2 PRKAA2 PRKAA2 SEH1L SEH1L RRAGC RRAGC TBC1D7 TBC1D7 MIOS MIOS FNIP1 FNIP1 FNIP2 FNIP2 SIRT1 SIRT1 RPS6KA6 RPS6KA6 NPRL2 NPRL2 SESN3 SESN3 METTL25 METTL25 MTOR MTOR AKAP8L AKAP8L AKT1 AKT1 FOXO3 FOXO3 RPS6KB1 RPS6KB1 C12orf66 C12orf66 TRIB1 TRIB1 STRADB STRADB SESN1 SESN1 MLST8 MLST8 TSSK3 TSSK3 DEPTOR DEPTOR LAMTOR3 LAMTOR3 RPS6KA3 RPS6KA3 CRYGN CRYGN MAP3K15 MAP3K15 RRAGD RRAGD RHEB RHEB TSC1 TSC1 RICTOR RICTOR SESN2 SESN2 COIL COIL K7FUU4_PELSI K7FUU4_PELSI CAMKK2 CAMKK2 PRR5L PRR5L CASTOR2 CASTOR2 STRADA STRADA PRKAG2 PRKAG2 NPRL3 NPRL3 WDR59 WDR59 LOC102449711 LOC102449711 RRAGB RRAGB SIRT3 SIRT3 PRKAB2 PRKAB2 BMT2 BMT2 TSC2 TSC2 K7G3A7_PELSI K7G3A7_PELSI WDR24 WDR24 SGK3 SGK3 MAPKAP1 MAPKAP1 PRKAA1 PRKAA1 ACSS2 ACSS2 DEPDC5 DEPDC5 FLCN FLCN ITFG2 ITFG2 RPS6KB2 RPS6KB2 K7GBN9_PELSI K7GBN9_PELSI PPM1A PPM1A CRYBB3 CRYBB3 SLC38A9 SLC38A9 LAMTOR4 LAMTOR4 CAB39 CAB39 PPM1B PPM1B SGK2 SGK2 PRR5 PRR5 PRKAB1 PRKAB1 DDIT4 DDIT4 RPTOR RPTOR TRIB3 TRIB3 LAMTOR5 LAMTOR5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102456451Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (271 aa)
LOC102456698Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (271 aa)
FOXO1FOXO-TAD domain-containing protein. (401 aa)
TSSK2Testis specific serine kinase 2; Belongs to the protein kinase superfamily. (364 aa)
FOXO4Forkhead box O4. (379 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (163 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (373 aa)
RHEBL1RHEB like 1. (139 aa)
RPS6KA2Ribosomal protein S6 kinase. (734 aa)
PRKAA2Non-specific serine/threonine protein kinase. (520 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (369 aa)
RRAGCRas related GTP binding C. (338 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
MIOSMeiosis regulator for oocyte development. (877 aa)
FNIP1Folliculin interacting protein 1. (1221 aa)
FNIP2Folliculin interacting protein 2. (1107 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (607 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (714 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (385 aa)
SESN3Sestrin 3. (496 aa)
METTL25Methyltransferase like 25. (483 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2522 aa)
AKAP8LA-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (546 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FOXO3Fork-head domain-containing protein. (587 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
C12orf66Chromosome 12 open reading frame 66. (309 aa)
TRIB1Tribbles pseudokinase 1. (257 aa)
STRADBSTE20 related adaptor beta. (416 aa)
SESN1Sestrin 1. (553 aa)
MLST8MTOR associated protein, LST8 homolog. (271 aa)
TSSK3Testis specific serine kinase 3. (257 aa)
DEPTORDEP domain containing MTOR interacting protein. (397 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (183 aa)
MAP3K15Mitogen-activated protein kinase kinase kinase 15. (1151 aa)
RRAGDRas related GTP binding D. (393 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
TSC1TSC complex subunit 1. (1168 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1715 aa)
SESN2Uncharacterized protein. (443 aa)
COILCoilin. (589 aa)
K7FUU4_PELSIProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (191 aa)
CAMKK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (468 aa)
PRR5LProline rich 5 like. (366 aa)
CASTOR2Uncharacterized protein. (329 aa)
STRADASTE20 related adaptor alpha. (430 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (564 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (491 aa)
WDR59WD repeat domain 59. (974 aa)
LOC102449711Uncharacterized protein. (369 aa)
RRAGBRas related GTP binding B. (313 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (335 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (274 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (371 aa)
TSC2TSC complex subunit 2. (1816 aa)
K7G3A7_PELSIProtein kinase domain-containing protein. (350 aa)
WDR24WD repeat domain 24. (789 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (586 aa)
DEPDC5DEP domain-containing protein. (1592 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (428 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (450 aa)
K7GBN9_PELSIUncharacterized protein. (418 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (134 aa)
SLC38A9Solute carrier family 38 member 9. (559 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (98 aa)
CAB39Calcium binding protein 39. (341 aa)
PPM1BPPM-type phosphatase domain-containing protein. (474 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (368 aa)
PRR5Proline rich 5. (404 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (263 aa)
DDIT4DNA damage inducible transcript 4. (223 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1245 aa)
TRIB3Uncharacterized protein. (135 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (79 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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