(17 nodes) Mixed, incl. Acetylcholine regulates insulin secretion, and Muscarinic acetylcholine receptors network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTAFR	Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	CHRM1	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (542 aa)
	CYSLTR2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (309 aa)
	CHRM3	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (614 aa)
	PTGFR	Prostaglandin F receptor. (362 aa)
	CYSLTR1	Cysteinyl leukotriene receptor 1. (341 aa)
	GPRC6A	G protein-coupled receptor class C group 6 member A. (927 aa)
	LOC102454459	Uncharacterized protein. (359 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1073 aa)
	GNA14	G protein subunit alpha 14. (350 aa)
	CASR	Calcium sensing receptor. (713 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1186 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1201 aa)
	GNA15	G protein subunit alpha 15. (386 aa)
	GNA11	G protein subunit alpha 11. (363 aa)
	K7G9Y5_PELSI	Phosphoinositide phospholipase C. (376 aa)
	PLCB4	Phosphoinositide phospholipase C. (661 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASR	GNA11	ENSPSIP00000012186	ENSPSIP00000016148	Calcium sensing receptor.	G protein subunit alpha 11.	0.412
CASR	GNA14	ENSPSIP00000012186	ENSPSIP00000011037	Calcium sensing receptor.	G protein subunit alpha 14.	0.412
CASR	GPRC6A	ENSPSIP00000012186	ENSPSIP00000009153	Calcium sensing receptor.	G protein-coupled receptor class C group 6 member A.	0.933
CASR	LOC102454459	ENSPSIP00000012186	ENSPSIP00000009810	Calcium sensing receptor.	Uncharacterized protein.	0.412
CASR	PLCB1	ENSPSIP00000012186	ENSPSIP00000010206	Calcium sensing receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.932
CASR	PLCB2	ENSPSIP00000012186	ENSPSIP00000012499	Calcium sensing receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.932
CASR	PLCB3	ENSPSIP00000012186	ENSPSIP00000014066	Calcium sensing receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.932
CASR	PLCB4	ENSPSIP00000012186	ENSPSIP00000017949	Calcium sensing receptor.	Phosphoinositide phospholipase C.	0.916
CHRM1	GNA11	ENSPSIP00000000656	ENSPSIP00000016148	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha 11.	0.791
CHRM1	GNA14	ENSPSIP00000000656	ENSPSIP00000011037	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha 14.	0.791
CHRM1	GNA15	ENSPSIP00000000656	ENSPSIP00000015073	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha 15.	0.781
CHRM1	LOC102454459	ENSPSIP00000000656	ENSPSIP00000009810	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Uncharacterized protein.	0.791
CHRM3	GNA11	ENSPSIP00000001862	ENSPSIP00000016148	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha 11.	0.791
CHRM3	GNA14	ENSPSIP00000001862	ENSPSIP00000011037	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha 14.	0.791
CHRM3	GNA15	ENSPSIP00000001862	ENSPSIP00000015073	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha 15.	0.781
CHRM3	LOC102454459	ENSPSIP00000001862	ENSPSIP00000009810	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Uncharacterized protein.	0.791
CYSLTR1	CYSLTR2	ENSPSIP00000006925	ENSPSIP00000001534	Cysteinyl leukotriene receptor 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.920
CYSLTR1	GNA11	ENSPSIP00000006925	ENSPSIP00000016148	Cysteinyl leukotriene receptor 1.	G protein subunit alpha 11.	0.748
CYSLTR1	GNA14	ENSPSIP00000006925	ENSPSIP00000011037	Cysteinyl leukotriene receptor 1.	G protein subunit alpha 14.	0.748
CYSLTR1	GNA15	ENSPSIP00000006925	ENSPSIP00000015073	Cysteinyl leukotriene receptor 1.	G protein subunit alpha 15.	0.748