(5 nodes) Prostate gland growth, and Nuclear receptor coactivator network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (588 aa)
	SP1	Sp1 transcription factor. (724 aa)
	NCOA1	Nuclear receptor coactivator. (1502 aa)
	AR	Androgen receptor. (721 aa)
	ESR2	Estrogen receptor 2. (556 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ESR1	ENSPSIP00000011283	ENSPSIP00000004470	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.679
AR	NCOA1	ENSPSIP00000011283	ENSPSIP00000008403	Androgen receptor.	Nuclear receptor coactivator.	0.824
AR	SP1	ENSPSIP00000011283	ENSPSIP00000007750	Androgen receptor.	Sp1 transcription factor.	0.670
ESR1	AR	ENSPSIP00000004470	ENSPSIP00000011283	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Androgen receptor.	0.679
ESR1	ESR2	ENSPSIP00000004470	ENSPSIP00000020581	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Estrogen receptor 2.	0.931
ESR1	NCOA1	ENSPSIP00000004470	ENSPSIP00000008403	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.807
ESR1	SP1	ENSPSIP00000004470	ENSPSIP00000007750	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Sp1 transcription factor.	0.931
ESR2	ESR1	ENSPSIP00000020581	ENSPSIP00000004470	Estrogen receptor 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.931
ESR2	NCOA1	ENSPSIP00000020581	ENSPSIP00000008403	Estrogen receptor 2.	Nuclear receptor coactivator.	0.757
ESR2	SP1	ENSPSIP00000020581	ENSPSIP00000007750	Estrogen receptor 2.	Sp1 transcription factor.	0.791
NCOA1	AR	ENSPSIP00000008403	ENSPSIP00000011283	Nuclear receptor coactivator.	Androgen receptor.	0.824
NCOA1	ESR1	ENSPSIP00000008403	ENSPSIP00000004470	Nuclear receptor coactivator.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.807
NCOA1	ESR2	ENSPSIP00000008403	ENSPSIP00000020581	Nuclear receptor coactivator.	Estrogen receptor 2.	0.757
SP1	AR	ENSPSIP00000007750	ENSPSIP00000011283	Sp1 transcription factor.	Androgen receptor.	0.670
SP1	ESR1	ENSPSIP00000007750	ENSPSIP00000004470	Sp1 transcription factor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.931
SP1	ESR2	ENSPSIP00000007750	ENSPSIP00000020581	Sp1 transcription factor.	Estrogen receptor 2.	0.791