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| | MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (798 aa) |
| | LIG4 | DNA ligase. (912 aa) |
| | RMI1 | RecQ mediated genome instability 1. (623 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa) |
| | FANCG | Uncharacterized protein. (75 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (548 aa) |
| | RAD54B | Uncharacterized protein. (918 aa) |
| | CDC7 | Cell division cycle 7. (569 aa) |
| | RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (297 aa) |
| | CDC45 | Cell division cycle 45. (596 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (213 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (689 aa) |
| | RECQL4 | Uncharacterized protein. (847 aa) |
| | PIF1 | ATP-dependent DNA helicase; Belongs to the helicase family. (336 aa) |
| | RAD9B | Uncharacterized protein. (141 aa) |
| | RAD54L | RAD54 like. (735 aa) |
| | TIMELESS | Timeless circadian regulator. (863 aa) |
| | K7F650_PELSI | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (382 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (484 aa) |
| | WSCD2 | WSC domain containing 2. (561 aa) |
| | GINS1 | GINS complex subunit 1. (160 aa) |
| | ORC5 | Origin recognition complex subunit 5. (447 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3047 aa) |
| | FANCC | FA complementation group C. (528 aa) |
| | SHPRH | SNF2 histone linker PHD RING helicase. (1681 aa) |
| | ORC2 | Origin recognition complex subunit 2. (585 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (319 aa) |
| | RPA3 | Replication protein A3. (119 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (169 aa) |
| | RECQL5 | RecQ5 domain-containing protein. (624 aa) |
| | GINS3 | GINS complex subunit 3. (156 aa) |
| | RFC5 | Replication factor C subunit 5. (319 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1283 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | K7FBT0_PELSI | Uncharacterized protein. (414 aa) |
| | LOC102452094 | NTF2 domain-containing protein. (127 aa) |
| | K7FC61_PELSI | BRCT_assoc domain-containing protein. (1048 aa) |
| | FANCE | FA complementation group E. (554 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1893 aa) |
| | POLM | DNA polymerase mu; Belongs to the DNA polymerase type-X family. (433 aa) |
| | MAD2L2 | HORMA domain-containing protein. (211 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (714 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (199 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (631 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3061 aa) |
| | DBF4 | DBF4 zinc finger. (675 aa) |
| | UBE2A | Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (788 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (470 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (738 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | RAD18 | RAD18 E3 ubiquitin protein ligase. (500 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (299 aa) |
| | TWNK | Twinkle mtDNA helicase. (527 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (580 aa) |
| | PAXX | Uncharacterized protein. (183 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (418 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (778 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (714 aa) |
| | POLD3 | Uncharacterized protein. (420 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (148 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (206 aa) |
| | NUDT15 | Nudix hydrolase 15. (162 aa) |
| | RFC3 | Replication factor C subunit 3. (304 aa) |
| | NEIL1 | Nei like DNA glycosylase 1. (423 aa) |
| | CLSPN | Claspin. (1345 aa) |
| | RFC1 | Replication factor C subunit 1. (1146 aa) |
| | LOC102454986 | Uncharacterized protein. (143 aa) |
| | TRIM25 | Tripartite motif containing 25. (678 aa) |
| | XRCC6 | Uncharacterized protein. (321 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (371 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (344 aa) |
| | K7FP83_PELSI | BRCT domain-containing protein. (519 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1517 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (482 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1831 aa) |
| | POLA1 | DNA polymerase. (1351 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (226 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (117 aa) |
| | TDG | Thymine DNA glycosylase. (433 aa) |
| | BLM | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (557 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (615 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (811 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | MUTYH | ENDO3c domain-containing protein. (428 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (338 aa) |
| | MLH1 | MutL homolog 1. (727 aa) |
| | LOC102463705 | Uncharacterized protein. (526 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (275 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1304 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2705 aa) |
| | FAAP24 | FA core complex associated protein 24. (217 aa) |
| | MSH4 | MutS homolog 4. (795 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (826 aa) |
| | CETN2 | Uncharacterized protein. (171 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (458 aa) |
| | K7FXF3_PELSI | Uncharacterized protein. (250 aa) |
| | APLF | Aprataxin and PNKP like factor. (548 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3083 aa) |
| | ORC3 | Origin recognition complex subunit 3. (724 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (295 aa) |
| | FANCA | Fanconi_A_N domain-containing protein. (734 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1129 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (901 aa) |
| | LOC102448166 | Uncharacterized protein. (186 aa) |
| | NEIL3 | Nei like DNA glycosylase 3. (384 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1183 aa) |
| | POLK | DNA polymerase kappa. (876 aa) |
| | LIG1 | DNA ligase. (954 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1062 aa) |
| | FANCB | FA complementation group B. (857 aa) |
| | MPG | N-methylpurine DNA glycosylase. (293 aa) |
| | UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (198 aa) |
| | EXO1 | Exonuclease 1. (808 aa) |
| | POLH | DNA polymerase eta. (596 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | MEIOB | Meiosis specific with OB-fold. (467 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (231 aa) |
| | HES4 | Hes family bHLH transcription factor 4. (292 aa) |
| | RFC2 | Replication factor C subunit 2. (374 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (191 aa) |
| | RAD51C | RAD51 paralog C. (367 aa) |
| | WRN | WRN RecQ like helicase. (1490 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1209 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (878 aa) |
| | FANCI | FA complementation group I. (1351 aa) |
| | FANCL | FA complementation group L. (344 aa) |
| | LOC102462305 | DNA helicase; Belongs to the MCM family. (812 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (931 aa) |
| | TDRD3 | Tudor domain containing 3. (651 aa) |
| | DDX58 | DExD/H-box helicase 58. (928 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (329 aa) |
| | POLQ | DNA polymerase theta. (2567 aa) |
| | OGG1 | Uncharacterized protein. (355 aa) |
| | K7G5T8_PELSI | DNA helicase; Belongs to the MCM family. (840 aa) |
| | FBH1 | F-box DNA helicase 1. (1045 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (683 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (742 aa) |
| | ORC6 | Origin recognition complex subunit 6. (272 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1310 aa) |
| | LIG3 | DNA ligase. (923 aa) |
| | CENPX | Uncharacterized protein. (81 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (984 aa) |
| | HLTF | Helicase like transcription factor. (914 aa) |
| | FANCM | FA complementation group M. (1903 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (175 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1692 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (536 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (144 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (392 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (690 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1273 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (949 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (691 aa) |
| | RAD51B | RAD51 paralog B. (243 aa) |
| | POLE3 | CBFD_NFYB_HMF domain-containing protein. (141 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1166 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (545 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1270 aa) |
| | RPA2 | Replication protein A2. (173 aa) |
| | HELQ | Helicase, POLQ like. (1007 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (865 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2166 aa) |
| | ATRIP | ATR interacting protein. (519 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (416 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (806 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (866 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (336 aa) |
| | POLI | DNA polymerase iota. (706 aa) |
| | CHEK2 | Checkpoint kinase 2. (440 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (671 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1051 aa) |
| | LOC102445415 | SAP domain-containing protein. (257 aa) |
| | DHX58 | DExH-box helicase 58. (670 aa) |
| | K7GEW4_PELSI | Piezo-type mechanosensitive ion channel component. (2540 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (306 aa) |
| | POLN | DNA polymerase nu. (661 aa) |
| | CDCA7 | Cell division cycle associated 7. (274 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1038 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (198 aa) |
| | RFC4 | Replication factor C subunit 4. (329 aa) |
| | MLH3 | MutL homolog 3. (1377 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1046 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4133 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (125 aa) |
| | K7GI78_PELSI | HORMA domain-containing protein. (154 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2661 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (825 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (394 aa) |
| | BIVM | Uncharacterized protein. (1604 aa) |
| | FANCD2 | FA complementation group D2. (1203 aa) |
