40 items (Pelodiscus sinensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RB1CC1	RB1 inducible coiled-coil 1. (1591 aa)
	LOC102450218	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (273 aa)
	FUNDC1	FUN14 domain containing 1. (100 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa)
	MAP1LC3C	Microtubule associated protein 1 light chain 3 gamma. (143 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (661 aa)
	ATG2B	Autophagy related 2B. (2079 aa)
	WDR45B	WD repeat domain 45B. (335 aa)
	FBXO7	F-box protein 7. (459 aa)
	TIGAR	Uncharacterized protein. (274 aa)
	PHB2	Prohibitin. (259 aa)
	SNX30	Sorting nexin family member 30. (468 aa)
	MAP1LC3A	Microtubule associated protein 1 light chain 3 alpha. (121 aa)
	ATG4B	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (392 aa)
	ATG14	Autophagy related 14. (393 aa)
	GABARAPL2	GABA type A receptor associated protein like 2. (106 aa)
	WIPI2	WD repeat domain, phosphoinositide interacting 2. (414 aa)
	WIPI1	WD repeat domain, phosphoinositide interacting 1. (422 aa)
	SQSTM1	Sequestosome 1. (437 aa)
	ATG2A	Autophagy related 2A. (2002 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1030 aa)
	SNX7	Sorting nexin 7. (442 aa)
	K7FIX1_PELSI	GSAP-16 domain-containing protein. (151 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (555 aa)
	RETREG1	Reticulophagy regulator 1. (420 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1301 aa)
	USP30	Ubiquitin carboxyl-terminal hydrolase. (489 aa)
	K7FDM1_PELSI	Uncharacterized protein. (254 aa)
	PRKN	RBR-type E3 ubiquitin transferase. (119 aa)
	PINK1	PTEN induced kinase 1. (364 aa)
	FUNDC2	FUN14 domain containing 2. (152 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (964 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (276 aa)
	FBXL4	F-box and leucine rich repeat protein 4. (623 aa)
	ATG3	Autophagy-related protein 3. (289 aa)
	C5orf51	Chromosome 5 open reading frame 51. (291 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (143 aa)
	MAP1LC3B	Uncharacterized protein. (112 aa)
	SPATA18	Spermatogenesis associated 18. (499 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (1015 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG12	ENSPSIP00000007005	ENSPSIP00000019454	Autophagy and beclin 1 regulator 1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.568
AMBRA1	ATG13	ENSPSIP00000007005	ENSPSIP00000007925	Autophagy and beclin 1 regulator 1.	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.805
AMBRA1	ATG14	ENSPSIP00000007005	ENSPSIP00000012051	Autophagy and beclin 1 regulator 1.	Autophagy related 14.	0.800
AMBRA1	ATG5	ENSPSIP00000007005	ENSPSIP00000002735	Autophagy and beclin 1 regulator 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.559
AMBRA1	ATG7	ENSPSIP00000007005	ENSPSIP00000013932	Autophagy and beclin 1 regulator 1.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.527
AMBRA1	K7FDM1_PELSI	ENSPSIP00000007005	ENSPSIP00000006131	Autophagy and beclin 1 regulator 1.	Uncharacterized protein.	0.434
AMBRA1	LOC102450218	ENSPSIP00000007005	ENSPSIP00000016911	Autophagy and beclin 1 regulator 1.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.482
AMBRA1	PRKN	ENSPSIP00000007005	ENSPSIP00000006123	Autophagy and beclin 1 regulator 1.	RBR-type E3 ubiquitin transferase.	0.941
AMBRA1	RB1CC1	ENSPSIP00000007005	ENSPSIP00000016994	Autophagy and beclin 1 regulator 1.	RB1 inducible coiled-coil 1.	0.710
AMBRA1	ULK1	ENSPSIP00000007005	ENSPSIP00000009949	Autophagy and beclin 1 regulator 1.	Unc-51 like autophagy activating kinase 1.	0.975
AMBRA1	ULK2	ENSPSIP00000007005	ENSPSIP00000017795	Autophagy and beclin 1 regulator 1.	Unc-51 like autophagy activating kinase 2.	0.968
ATG12	AMBRA1	ENSPSIP00000019454	ENSPSIP00000007005	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy and beclin 1 regulator 1.	0.568
ATG12	ATG13	ENSPSIP00000019454	ENSPSIP00000007925	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.689
ATG12	ATG14	ENSPSIP00000019454	ENSPSIP00000012051	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 14.	0.909
ATG12	ATG2A	ENSPSIP00000019454	ENSPSIP00000010531	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 2A.	0.542
ATG12	ATG2B	ENSPSIP00000019454	ENSPSIP00000013916	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 2B.	0.542
ATG12	ATG3	ENSPSIP00000019454	ENSPSIP00000002248	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 3.	0.999
ATG12	ATG4B	ENSPSIP00000019454	ENSPSIP00000012313	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.746
ATG12	ATG5	ENSPSIP00000019454	ENSPSIP00000002735	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	ATG7	ENSPSIP00000019454	ENSPSIP00000013932	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999