STRINGSTRING
MVK MVK HSD17B7 HSD17B7 CFTR CFTR DHCR7 DHCR7 CYP51A1 CYP51A1 SC5D SC5D HMGCS1 HMGCS1 LOC102458644 LOC102458644 FDPS FDPS MVD MVD INSIG2 INSIG2 FDFT1 FDFT1 LOC102453483 LOC102453483 DHCR24 DHCR24 PRKAA2 PRKAA2 INSIG1 INSIG1 LBR LBR PRKAA1 PRKAA1 APOA5 APOA5 HMGCR HMGCR G6PD G6PD LSS LSS NSDHL NSDHL EBP EBP TM7SF2 TM7SF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (417 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (334 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1015 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (502 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (293 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (522 aa)
LOC102458644Nudix hydrolase domain-containing protein. (244 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (296 aa)
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (391 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
FDFT1Uncharacterized protein. (420 aa)
LOC102453483Uncharacterized protein. (292 aa)
DHCR2424-dehydrocholesterol reductase. (516 aa)
PRKAA2Non-specific serine/threonine protein kinase. (520 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (276 aa)
LBRLamin B receptor. (617 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
APOA5Apolipoprotein A5. (364 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (881 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (513 aa)
LSSLanosterol synthase. (488 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (345 aa)
EBPEXPERA domain-containing protein. (220 aa)
TM7SF2Transmembrane 7 superfamily member 2. (420 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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