STRINGSTRING
WRN WRN TP53 TP53 WDR24 WDR24 BMT2 BMT2 SLC7A5 SLC7A5 MAP1LC3C MAP1LC3C KLF10 KLF10 RRAGB RRAGB ATG7 ATG7 WDR45B WDR45B WDR59 WDR59 PIK3C3 PIK3C3 NPRL3 NPRL3 PRKAG2 PRKAG2 MAP1LC3A MAP1LC3A TFEB TFEB ATF4 ATF4 JMY JMY FOXO3 FOXO3 SIK1 SIK1 MTOR MTOR DNAJC15 DNAJC15 SESN3 SESN3 NPRL2 NPRL2 WHAMM WHAMM AMBRA1 AMBRA1 SIRT1 SIRT1 SREBF1 SREBF1 FOXA3 FOXA3 ZFYVE1 ZFYVE1 FAS FAS FNIP1 FNIP1 HSPA5 HSPA5 STK26 STK26 MIOS MIOS BECN1 BECN1 RRAGC RRAGC TNRC6A TNRC6A SEH1L SEH1L PRKAA2 PRKAA2 PCSK9 PCSK9 WNT9B WNT9B BCL2 BCL2 MTMR3 MTMR3 NFE2L2 NFE2L2 ATG5 ATG5 PIK3R4 PIK3R4 CLEC16A CLEC16A K7F3Q0_PELSI K7F3Q0_PELSI KRT19 KRT19 IMPACT IMPACT DAP DAP RNF152 RNF152 BHLHA15 BHLHA15 FOXO1 FOXO1 LRRK2 LRRK2 FLCN FLCN SIK2 SIK2 ITFG2 ITFG2 MFSD2A MFSD2A K7GBN9_PELSI K7GBN9_PELSI LARS1 LARS1 NUAK1 NUAK1 FBXO22 FBXO22 MAP1LC3B MAP1LC3B K7GG98_PELSI K7GG98_PELSI CBWD1 CBWD1 LAMP2 LAMP2 NIM1K NIM1K VPS41 VPS41 RPTOR RPTOR ATF3 ATF3 EIF2AK2 EIF2AK2 PPARA PPARA TTC5 TTC5 ATG14 ATG14 GABARAPL2 GABARAPL2 WIPI2 WIPI2 SESN2 SESN2 EIF2AK3 EIF2AK3 RRAGD RRAGD XPR1 XPR1 WIPI1 WIPI1 EIF2AK4 EIF2AK4 PLIN2 PLIN2 ZC3H12A ZC3H12A NUAK2 NUAK2 GAS6 GAS6 SESN1 SESN1 C12orf66 C12orf66 MYBBP1A MYBBP1A XBP1 XBP1 BRSK2 BRSK2 TBL2 TBL2 PPM1D PPM1D UPP1 UPP1 SREBF2 SREBF2 GCN1 GCN1 DEPDC5 DEPDC5 EIF2S1 EIF2S1 PICK1 PICK1 PRKAA1 PRKAA1 BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WRNWRN RecQ like helicase. (1490 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa)
WDR24WD repeat domain 24. (789 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (371 aa)
SLC7A5Solute carrier family 7 member 5. (428 aa)
MAP1LC3CMicrotubule associated protein 1 light chain 3 gamma. (143 aa)
KLF10Kruppel like factor 10. (482 aa)
RRAGBRas related GTP binding B. (313 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (661 aa)
WDR45BWD repeat domain 45B. (335 aa)
WDR59WD repeat domain 59. (974 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (864 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (491 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (564 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
TFEBTranscription factor EB. (480 aa)
ATF4Activating transcription factor 4. (356 aa)
JMYJunction mediating and regulatory protein, p53 cofactor. (712 aa)
FOXO3Fork-head domain-containing protein. (587 aa)
SIK1Uncharacterized protein. (798 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2522 aa)
DNAJC15DnaJ heat shock protein family (Hsp40) member C15. (110 aa)
SESN3Sestrin 3. (496 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (385 aa)
WHAMMWASP homolog associated with actin, golgi membranes and microtubules. (504 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (607 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (919 aa)
FOXA3Fork-head domain-containing protein. (388 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (781 aa)
FASFas cell surface death receptor. (303 aa)
FNIP1Folliculin interacting protein 1. (1221 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (613 aa)
STK26Serine/threonine kinase 26. (416 aa)
MIOSMeiosis regulator for oocyte development. (877 aa)
BECN1Uncharacterized protein. (407 aa)
RRAGCRas related GTP binding C. (338 aa)
TNRC6ATrinucleotide repeat containing adaptor 6A. (1414 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (369 aa)
PRKAA2Non-specific serine/threonine protein kinase. (520 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (690 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (333 aa)
BCL2BCL2 apoptosis regulator. (232 aa)
MTMR3Myotubularin related protein 3. (1188 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (573 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (276 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1359 aa)
CLEC16AFPL domain-containing protein. (593 aa)
K7F3Q0_PELSIIF rod domain-containing protein; Belongs to the intermediate filament family. (168 aa)
KRT19IF rod domain-containing protein; Belongs to the intermediate filament family. (214 aa)
IMPACTImpact RWD domain protein. (306 aa)
DAPUncharacterized protein. (87 aa)
RNF152Ring finger protein 152. (203 aa)
BHLHA15Basic helix-loop-helix family member a15. (175 aa)
FOXO1FOXO-TAD domain-containing protein. (401 aa)
LRRK2Leucine rich repeat kinase 2. (2537 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
SIK2Salt inducible kinase 2. (834 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (428 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (503 aa)
K7GBN9_PELSIUncharacterized protein. (418 aa)
LARS1Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1169 aa)
NUAK1NUAK family kinase 1. (641 aa)
FBXO22F-box protein 22. (414 aa)
MAP1LC3BUncharacterized protein. (112 aa)
K7GG98_PELSIUncharacterized protein. (438 aa)
CBWD1Uncharacterized protein. (393 aa)
LAMP2Lysosomal associated membrane protein 2. (480 aa)
NIM1KNIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (244 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1245 aa)
ATF3Activating transcription factor 3. (181 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (569 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
TTC5Tetratricopeptide repeat domain 5. (427 aa)
ATG14Autophagy related 14. (393 aa)
GABARAPL2GABA type A receptor associated protein like 2. (106 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (414 aa)
SESN2Uncharacterized protein. (443 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1028 aa)
RRAGDRas related GTP binding D. (393 aa)
XPR1Xenotropic and polytropic retrovirus receptor 1. (666 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (422 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa)
PLIN2Perilipin; Belongs to the perilipin family. (465 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (573 aa)
NUAK2NUAK family kinase 2. (614 aa)
GAS6Growth arrest specific 6. (403 aa)
SESN1Sestrin 1. (553 aa)
C12orf66Chromosome 12 open reading frame 66. (309 aa)
MYBBP1AMYB binding protein 1a. (967 aa)
XBP1Uncharacterized protein. (292 aa)
BRSK2BR serine/threonine kinase 2. (599 aa)
TBL2Transducin beta like 2. (409 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (596 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (313 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (668 aa)
GCN1GCN1 activator of EIF2AK4. (2669 aa)
DEPDC5DEP domain-containing protein. (1592 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
PICK1Protein interacting with PRKCA 1. (407 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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