STRINGSTRING
MSH2 MSH2 K7GCY2_PELSI K7GCY2_PELSI SDE2 SDE2 USP1 USP1 PARP1 PARP1 CASP7 CASP7 PRIMPOL PRIMPOL MAP2K7 MAP2K7 CUL4B CUL4B PBK PBK ATR ATR MAP3K4 MAP3K4 IL12B IL12B BIVM BIVM BRCA2 BRCA2 DCUN1D3 DCUN1D3 POLK POLK UBE4B UBE4B NOC2L NOC2L RHBDD1 RHBDD1 OPN3 OPN3 DHX36 DHX36 POLH POLH MFAP4 MFAP4 OPN5 OPN5 SIRT1 SIRT1 METTL3 METTL3 AQP5 AQP5 UVSSA UVSSA ACTR5 ACTR5 ZRANB3 ZRANB3 SPRTN SPRTN MSH6 MSH6 UBE2B UBE2B CASP9 CASP9 EP300 EP300 MEN1 MEN1 ZBTB1 ZBTB1 BCL2 BCL2 KDM1A KDM1A OPN1SW OPN1SW STK11 STK11 ERCC8 ERCC8 IMPACT IMPACT PCNA PCNA TRIM32 TRIM32 LOC102455469 LOC102455469 MAPK13 MAPK13 CAT CAT POLD3 POLD3 USF1 USF1 MYC MYC CREBBP CREBBP SIRT6 SIRT6 DDB2 DDB2 K7FQ62_PELSI K7FQ62_PELSI EIF2AK4 EIF2AK4 C9orf116 C9orf116 TP53INP1 TP53INP1 XPA XPA BMF BMF TP53 TP53 WRN WRN DDB1 DDB1 BAK1 BAK1 USP47 USP47 PRKAA1 PRKAA1 K7G6G0_PELSI K7G6G0_PELSI CUL4A CUL4A EIF2S1 EIF2S1 K7G788_PELSI K7G788_PELSI INO80 INO80 AQP1 AQP1 RUVBL2 RUVBL2 ERCC3 ERCC3 ERCC6 ERCC6 XPC XPC PPID PPID REV1 REV1 UBE2A UBE2A TMEM161A TMEM161A PTPRK PTPRK ERCC4 ERCC4 RO60 RO60 CCND1 CCND1 ERCC1 ERCC1 DTL DTL CHEK1 CHEK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (866 aa)
K7GCY2_PELSIFibronectin type-II domain-containing protein. (398 aa)
SDE2SDE2 telomere maintenance homolog. (316 aa)
USP1Ubiquitin specific peptidase 1; Belongs to the peptidase C19 family. (668 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (975 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (312 aa)
PRIMPOLPrimase and DNA directed polymerase. (607 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (396 aa)
CUL4BCullin 4B; Belongs to the cullin family. (913 aa)
PBKPDZ binding kinase. (322 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2661 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1555 aa)
IL12BInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (321 aa)
BIVMUncharacterized protein. (1604 aa)
BRCA2BRCA2 DNA repair associated. (3083 aa)
DCUN1D3DCN1-like protein. (304 aa)
POLKDNA polymerase kappa. (876 aa)
UBE4BUbiquitination factor E4B. (1348 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (657 aa)
RHBDD1Rhomboid domain containing 1. (324 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (273 aa)
DHX36DEAH-box helicase 36. (908 aa)
POLHDNA polymerase eta. (596 aa)
MFAP4Microfibril associated protein 4. (259 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (369 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (607 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (532 aa)
AQP5Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
UVSSAUncharacterized protein. (716 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (463 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1119 aa)
SPRTNSprT-like N-terminal domain. (405 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1283 aa)
UBE2BUbiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (423 aa)
EP300E1A binding protein p300. (2399 aa)
MEN1Menin 1. (605 aa)
ZBTB1Zinc finger and BTB domain containing 1. (640 aa)
BCL2BCL2 apoptosis regulator. (232 aa)
KDM1ALysine demethylase 1A. (1099 aa)
OPN1SWOpsin 1, short wave sensitive. (245 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (373 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
IMPACTImpact RWD domain protein. (306 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
TRIM32Tripartite motif containing 32. (647 aa)
LOC102455469G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (348 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (531 aa)
POLD3Uncharacterized protein. (420 aa)
USF1Upstream transcription factor 1. (331 aa)
MYCMYC proto-oncogene, bHLH transcription factor. (324 aa)
CREBBPCREB binding protein. (2063 aa)
SIRT6Sirtuin 6. (341 aa)
DDB2Damage specific DNA binding protein 2. (508 aa)
K7FQ62_PELSIUncharacterized protein. (809 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa)
C9orf116Chromosome 9 open reading frame 116. (137 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (236 aa)
XPAXPA, DNA damage recognition and repair factor. (226 aa)
BMFBcl2 modifying factor. (193 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa)
WRNWRN RecQ like helicase. (1490 aa)
DDB1Damage specific DNA binding protein 1. (1124 aa)
BAK1BCL2 antagonist/killer 1. (213 aa)
USP47Uncharacterized protein. (816 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
K7G6G0_PELSICULLIN_2 domain-containing protein; Belongs to the cullin family. (189 aa)
CUL4ACULLIN_2 domain-containing protein; Belongs to the cullin family. (571 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
K7G788_PELSILIM zinc-binding domain-containing protein. (62 aa)
INO80INO80 complex ATPase subunit. (1561 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (325 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (717 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1273 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (949 aa)
PPIDPeptidylprolyl isomerase D. (364 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1270 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
TMEM161ATransmembrane protein 161A. (486 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1369 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (738 aa)
RO60Ro60, Y RNA binding protein. (538 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (275 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (680 aa)
CHEK1Checkpoint kinase 1. (454 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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